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DRD4

  • Official Full Name

    dopamine receptor D4

  • Overview

    This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.DRD4 expression has been reported in various regions of the brain as well as in adrenal gland, artery, eye, heart, kidney, placenta, spinal cord, testis, and vas deferens
  • Synonyms

    DRD4; D(4) dopamine receptor; OTTHUMP00000164435; dopamine D4 receptor; D(2C) dopamine receptor; seven transmembrane helix receptor; dopamine receptor D4; D4DR;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Mustela putorius furo (European domestic ferret) (Mustela furo)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DRD4-1101HFL Recombinant Human DRD4 protein, His&Flag-tagged HEK293 His&Flag 1-419 aa
Mouse DRD4-4825M Recombinant Mouse DRD4 Protein Mammalian Cell His
Mouse DRD4-2529M-B Recombinant Mouse DRD4 Protein Pre-coupled Magnetic Beads HEK293
Mouse DRD4-2529M Recombinant Mouse DRD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DRD4-1958R Recombinant Rat DRD4 Protein Mammalian Cell His
Rat DRD4-1617R Recombinant Rat DRD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DRD4-1617R-B Recombinant Rat DRD4 Protein Pre-coupled Magnetic Beads HEK293
Rat DRD4-3389R Recombinant Rat DRD4 protein, His-tagged HEK293 His Ala209~Arg314
Rat DRD4-3386R Recombinant Rat DRD4 protein, His-tagged HEK293 His Ala209~Arg314
Homo sapiens (Human) RFL18847HF Recombinant Full Length Human D(4) Dopamine Receptor(Drd4) Protein, His-Tagged E.coli expression system His Full Length (1-467)
Mus musculus (Mouse) RFL9213MF Recombinant Full Length Mouse D(4) Dopamine Receptor(Drd4) Protein, His-Tagged E.coli expression system His Full Length (1-387)
Mustela putorius furo (European domestic ferret) (Mustela furo) RFL21206MF Recombinant Full Length Mustela Putorius Furo D(4) Dopamine Receptor(Drd4) Protein, His-Tagged E.coli expression system His Full Length (1-357)
Rattus norvegicus (Rat) RFL21958RF Recombinant Full Length Rat D(4) Dopamine Receptor(Drd4) Protein, His-Tagged E.coli expression system His Full Length (1-387)
Chicken DRD4-3897C Recombinant Chicken DRD4 Mammalian Cell His
Kit-0993 Fluorimetric Peroxidase Assay Kit (Near Infrared Fluorescence) N/A
Kit-1217 DRD4 CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DRD4 involved in several pathways and played different roles in them. We selected most pathways DRD4 participated on our site, such as Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), Dopamine receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amine ligand-binding receptorsDRD5;DRD2;CHRM3;ADRB1;ADRB2;ADRA2A;CHRM4;ADRa1A;CHRM2
Class A/1 (Rhodopsin-like receptors)PRLH;GPR4;GPR55;SST;ZFPM2B;PROKR2;DRD2;CCR1;APLNR
Dopamine receptorsDRD5;DRD4;DRD1;DRD3;DRD2
Dopaminergic synapsePRKCG;PPP3CB;SLC6A3;PPP2R5C;SLC18A1;AKT2;MAOB;MAPK8;PPP2R5B
G alpha (i) signalling eventsRGS14;AGTR2;LPAR2B;RGS18;CCR8;NMS;AGT;CCR3;PNOCB
GPCR downstream signalingOR52B4;AGT;OPN1LW;AGTR2;CCR9;NMUR1;PYY;OXGR1A.1;PTH2
GPCR ligand bindingMLN;PPY;GPR17;PMCH;S1PR3;OPN4A;CCR1;DRD3;EMR1
GPCRs, Class A Rhodopsin-likeHRH3;FPR-RS4;OPN1MW;GPR65;GPR37L1;GPR171;GPR75;GPR39;GPR27

DRD4 has several biochemical functions, for example, G-protein coupled amine receptor activity, SH3 domain binding, dopamine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DRD4 itself. We selected most functions DRD4 had, and list some proteins which have the same functions with DRD4. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled amine receptor activityTAAR2;DRD1B;GPR161;TAAR4;TAAR8A;DRD4B;DRD4A;TAAR7B;TAAR7A
SH3 domain bindingITM2B;SKAP1;QKI2;UVRAG;ENKUR;ELMO3;SOS1;TOM1L1;VASPA
dopamine bindingGPR143;DRD2;ADRB2;TH;DRD2L;SLC6A3;DRD4;DRD1;DRD2A
dopamine neurotransmitter receptor activityDRD2L;DRD4A;DRD1B;DRD7;DRD4;DRD2A;DRD2B;DRD5;DRD1
dopamine neurotransmitter receptor activity, coupled via Gi/GoDRD2L;DRD4A;DRD2;DRD4;DRD4B;DRD3;DRD2B;DRD4-RS;DRD2A
drug bindingFSCN1;HMGB2;CHRNA3;PDXK;SMO;CYP4B1;CHRNA7;CYP2C9;Alb
identical protein bindingCCDC155;UBE2G2;C1S;CHMP4B;ALCAMB;FZD1;CLPP;TYSND1;CDC42
potassium channel regulator activitySGK1;KCNMB4;NEDD4L;DRD4;KCNS3;SUMO1;KCNMB3;ARPP19;KCNMB1
protein bindingSTAC3;ZNF423;MYO18A;REST;PLOD3;ARSI;RBX1;DPM2;ZNF83

DRD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRD4.

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