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Official Full Name desmoglein 3
Background Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008]
Synonyms DSG3; desmoglein 3; PVA; CDHF6; desmoglein-3; cadherin family member 6; pemphigus vulgaris antigen; 130-kD pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • NS0
    • Yeast
    • Tag :
    • Fc
    • His
    • GST
    • SUMO
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse DSG3-1795M Recombinant Mouse DSG3 Protein (50-617 aa), His-SUMO-tagged E.coli His/SUMO
    Mouse DSG3-1838M Recombinant Mouse DSG3 Protein (50-617 aa), His-tagged Yeast His
    Human DSG3-461H Recombinant Human DSG3 Protein (50-615 aa), His-SUMO-tagged E.coli His/SUMO
    Human DSG3-38H Recombinant Human DSG3, Fc-tagged NS0 Fc
    Human DSG3-668H Recombinant Human DSG3 Protein, His/GST-tagged E.coli His/GST

    dsg3 involved in several pathways and played different roles in them. We selected most pathways dsg3 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with dsg3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptotic cleavage of cell adhesion proteins PTBP3; DSG1; DSG3; DSG2; CTNNB2; OCLN; PKP1; DSP; CTNNB1
    Apoptotic cleavage of cellular proteins DBNL; CASP8L1; CASP6L1; CASP6L2; DSP; STK26; PTBP3; DBNLA; PLECA; PLEC
    Apoptotic execution phase SATB1; SPNA2; CASP8L1; CTNNB1; BCAP31; PANK1A; HIST1H1C; DSG3; VIML; DFFA
    Programmed Cell Death HMGB2A; GZMC; VIML; SATB1; DSG3; RIPK3; DAPK3; DSP; STK24A; BAXB

    dsg3 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dsg3 itself. We selected most functions dsg3 had, and list some proteins which have the same functions with dsg3. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding CDH9; EHD2; CRELD2; NOTCH3; PCDH1A4; LTBP2; ADAMTS13; MYL1; DST; ASPH

    dsg3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dsg3 here. Most of them are supplied by our site. Hope this information will be useful for your research of dsg3.

    Di Zenzo, G; Zambruno, G; et al. Clonal Analysis of B-Cell Response in Pemphigus Course: Toward More Effective Therapies. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:651-654(2015).
    Hammers, CM; Chen, J; et al. Persistence of Anti-Desmoglein 3 IgG(+) B-Cell Clones in Pemphigus Patients over Years. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:742-749(2015).

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