DSG3

  • Official Full Name

    desmoglein 3

  • Overview

    Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008]
  • Synonyms

    DSG3; desmoglein 3; PVA; CDHF6; desmoglein-3; cadherin family member 6; pemphigus vulgaris antigen; 130-kD pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • CHO
  • Confidential
  • E.coli
  • HEK293
  • Insect Cell
  • Insect cells
  • Insect Cells
  • Mammalian cells
  • Yeast
  • C
  • Fc
  • hFc
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • His|SUMO
  • SUMO
  • N/A
  • N
  • GST
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DSG3-38H Active Recombinant Human DSG3, Fc-tagged Mammalian cells Fc
Human DSG3-12H Recombinant Human DSG3 Protein, C-His-tagged CHO C-His Glu24-Lys499
Human DSG3-668H Recombinant Human DSG3 Protein, His/GST-tagged E.coli His/GST Glu858~Ile999
Human DSG3-50H-B Recombinant Human DSG3 Protein Pre-coupled Magnetic Beads HEK293
Human DSG3-0268H Recombinant Human DSG3 Protein, Tag Free Confidential Tag Free
Human DSG3-461H Recombinant Human DSG3 Protein (50-615 aa), His-SUMO-tagged E.coli His/SUMO 50-615 aa
Human DSG3-2825H Recombinant Human DSG3 protein, His-SUMO-tagged E.coli His-SUMO 70-615aa
Human DSG3-7787H Recombinant Human DSG3 protein E.coli N/A 50-615aa
Human DSG3-1995H Recombinant Human DSG3 Protein (Asp269-Arg384), C-His tagged E.coli C-His Asp269-Arg384
Human DSG3-50H Recombinant Human DSG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DSG3-2826H Recombinant Human DSG3 protein, His-SUMO-tagged E.coli His-SUMO 70-499aa
Human DSG3-1996H Recombinant Human DSG3 Protein (Asp500-Arg615), C-His tagged E.coli C-His Asp500-Arg615
Human DSG3-1997H Recombinant Human DSG3 Protein (Gln159-Arg268), C-His tagged E.coli C-His Gln159-Arg268
Human DSG3-1998H Recombinant Human DSG3 Protein (Glu50-Ser158), C-His tagged E.coli C-His Glu50-Ser158
Human DSG3-2827H Recombinant Human DSG3 protein, His-tagged E.coli His 50-615aa
Human DSG3-4068H Recombinant Human DSG3 Protein (Glu50-Arg615), C-His tagged Insect Cells C-His Glu50-Arg615
Human DSG3-4069H Recombinant Human DSG3 Protein (Glu50-Arg615), C-Fc tagged Mammalian cells C-Fc Glu50-Arg615
Human DSG3-1389H Recombinant Human DSG3 Protein, His-tagged E.coli N-His Ala334-Pro604
Human DSG3-5905H Recombinant Human DSG3 protein, His&Myc-tagged Insect Cell His&Myc 50-615aa
Human DSG3-1999H Recombinant Human DSG3 Protein (Glu858-Ile999), N-GST tagged E.coli N-GST Glu858-Ile999
Human DSG3-2000H Recombinant Human DSG3 Protein (Pro385-Lys499), C-His tagged E.coli C-His Pro385-Lys499
Human DSG3-4070H Recombinant Human DSG3 Protein (Glu50-Arg615), C-His tagged Mammalian cells C-His Glu50-Arg615
Mouse DSG3-1795M Recombinant Mouse DSG3 Protein (50-617 aa), His-SUMO-tagged E.coli His/SUMO 50-617 aa
Mouse Dsg3-2215M Recombinant Mouse Dsg3 protein, His-tagged Insect Cell His 50-617aa
Mouse Dsg3-7432M Recombinant Mouse Dsg3 protein, hFc-tagged Insect cells C-hFc 50-617aa
Mouse Dsg3-2828M Recombinant Mouse Dsg3 protein, His-tagged E.coli His 50-617aa
Mouse DSG3-1838M Recombinant Mouse DSG3 Protein (50-617 aa), His-tagged Yeast His 50-617 aa
Mouse Dsg3-4222M Recombinant Mouse Dsg3 protein E.coli N/A 50-617aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

DSG3 involved in several pathways and played different roles in them. We selected most pathways DSG3 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisPIK3R5;CDKN2A;DYNLL2;PIK3CB;TICAM1;BCL2;AKT1;SPNA2;TNFRSFA
Apoptotic cleavage of cell adhesion proteinsDSG1;PKP1;PTBP3;CTNNB1;DSP;DSG3;CTNNB2;DSG2;OCLN
Apoptotic cleavage of cellular proteinsCLSPN;VIML;DSG3;DBNLB;PTBP3;PLEC;DSG2;STK26;DBNL
Apoptotic execution phaseADD1;SPNA2;CLSPN;STK24A;DSG2;CTNNB2;PKP1;GAS2;LMNB1
Programmed Cell DeathDAPK1;DSG2;DIABLOA;RNF8;GZMC;BAXB;MLKL;CASP6L1;DIABLO

DSG3 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSG3 itself. We selected most functions DSG3 had, and list some proteins which have the same functions with DSG3. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingEDEM2;SYT16;MCFD2;CD248;PCDH1G26;ZFP652;ABP1;aLA;PCDH1G11

DSG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSG3.

Research Area

Related articles

Di Zenzo, G; Zambruno, G; et al. Clonal Analysis of B-Cell Response in Pemphigus Course: Toward More Effective Therapies. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:651-654(2015).
Hammers, CM; Chen, J; et al. Persistence of Anti-Desmoglein 3 IgG(+) B-Cell Clones in Pemphigus Patients over Years. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:742-749(2015).
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