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DUSP19

Official Full Name

dual specificity phosphatase 19
Overview

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based;protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine;and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19;contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by;alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of;DUSPs (see MIM 600714) (summary by Patterson et al., 2009 (PubMed 19228121)).
Synonyms

DUSP19; dual specificity phosphatase 19; dual specificity protein phosphatase 19; DUSP17; SKRP1; Dual specificity phosphatase TS DSP1; Dual specificity phosphatase TS-DSP1; DUS19_HUMAN; DUSP 17; DUSP 19; LMW DSP3; LMW-DSP3; LMWDSP 3; LMWDSP3; Low molecular weight dual specificity phosphatase 3; MGC138210; Protein phosphatase SKRP1; SAPK pathway regulating phosphatase 1; SAPK pathway-regulating phosphatase 1; SKRP 1; Stress activated protein kinase pathway regulating phosphatase 1; Stress-activated protein kinase pathway-regulating phosphatase 1; TS DSP1; TS-DSP1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DUSP19-12211H	Recombinant Human DUSP19, GST-tagged	E.coli	GST	1-217a.a.	$319 / 25ug
Human	DUSP19-1317H	Recombinant Human Dual Specificity Phosphatase 19, His-tagged	E.coli	His		Inquiry
Human	DUSP19-28073TH	Recombinant Human DUSP19, His-tagged		His		Inquiry
Human	DUSP19-2932H	Recombinant Human DUSP19 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DUSP19-6779HCL	Recombinant Human DUSP19 293 Cell Lysate	HEK293	N/A		Inquiry
Human	DUSP19-4100HF	Recombinant Full Length Human DUSP19 Protein, GST-tagged	In Vitro Cell Free System	GST	217 amino acids	Inquiry
Mouse	Dusp19-2686M	Recombinant Mouse Dusp19 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rhesus Macaque	DUSP19-1351R	Recombinant Rhesus monkey DUSP19 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	DUSP19-1176R	Recombinant Rhesus Macaque DUSP19 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	DUSP19-1176R-B	Recombinant Rhesus Macaque DUSP19 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
DUSP19 Related Articles

DUSP19 involved in several pathways and played different roles in them. We selected most pathways DUSP19 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

DUSP19 has several biochemical functions, for example, JUN kinase phosphatase activity, MAP-kinase scaffold activity, mitogen-activated protein kinase kinase kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP19 itself. We selected most functions DUSP19 had, and list some proteins which have the same functions with DUSP19. You can find most of the proteins on our site.

Function	Related Protein
JUN kinase phosphatase activity	PTPRQ;PXYLP1;DUSP19;CTDSPL2A;SGPP2;NT5DC3;SACM1LB;SACM1L;TENC1
MAP-kinase scaffold activity	JIP1;CD36;DUSP19;MAPK8IP3;MAPK8IP2;SPAG9A;KSR1;SPAG9
mitogen-activated protein kinase kinase kinase binding	TRAF2;MAP4K2;MAP3K11;CDC42;STK38;TCF3;TRAF6;MAPK8IP3;DUSP19
protein binding	TOLLIP;CACNB2;FGFR1;WDFY3;PTPN6;FUS;PLIN5;COG2;GSTP1
protein kinase activator activity	WNT11;MARK2;NCKAP1L;DAXX;MAPK8IP2;NKX3;FGF13;GPRC5B;DUSP19
protein kinase inhibitor activity	TESC;NCK1;CHP1;CD36;SOCS6B;CAMK2N1A;SH3BP5;TAOK3;SOCS1A
protein tyrosine phosphatase activity	DUSP3B;DUSP2;DUSP14;CDC14A;PTPRA;TIMM50;CDC25B;PTPN23A;PTPRM
protein tyrosine/threonine phosphatase activity	DUSP1;DUSP2;NT5DC3;CTDSPL2B;SACM1LA;TENC1;DUSP19;PTPRQ;SGPP2

DUSP19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP19 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP19.

ALAS1

Ma, JJ; Yu, XY; et al. DUSP6, a tumor suppressor, is involved in differentiation and apoptosis in esophageal squamous cell carcinoma. ONCOLOGY LETTERS 6:1624-1630(2013).

Cagnol, S; Rivard, N; et al. Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition. ONCOGENE 32:564-576(2013).