DUSP2
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Official Full Name
dual specificity phosphatase 2 -
Overview
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily.These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. -
Synonyms
DUSP2;dual specificity phosphatase 2;dual specificity protein phosphatase 2;PAC 1;Dual specificity protein phosphatase PAC 1;DUSP 2;PAC1;Serine/threonine specific protein phosphatase;OTTHUMP00000161013;dual-specificity phosphatase 2;dual specificity protein phosphatase PAC-1;PAC-1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Wheat Germ
- E.coli
- Mammalian Cells
- In Vitro Cell Free System
- HEK293
- GST
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DUSP2-101H | Recombinant Human DUSP2, GST-tagged | Wheat Germ | Human | GST |
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| DUSP2-45H | Recombinant Human DUSP2 protein, His-tagged | E.coli | Human | His | 185aa(including fusion tag) |
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| DUSP2-4883M | Recombinant Mouse DUSP2 Protein | Mammalian Cells | Mouse | His |
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| DUSP2-898Z | Recombinant Zebrafish DUSP2 | Mammalian Cells | Zebrafish | His |
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| DUSP2-132HF | Recombinant Full Length Human DUSP2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 1 a.a. - 314 a.a. |
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| DUSP2-2566M | Recombinant Mouse DUSP2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| DUSP2-2566M-B | Recombinant Mouse DUSP2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
DUSP2 involved in several pathways and played different roles in them. We selected most pathways DUSP2 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | KIF4A,SPRED1,DUSP1,EFNB3,CRMP1,WDR83,FGF8B,FGFR1B,COL9A3,AP2A1 |
| Downstream signal transduction | SPRED3,FGFR1B,IL17RD,FGF20A,PAQR3B,PHB,TRAT1,JAK1,FRS2B,WDR83 |
| Downstream signaling of activated FGFR1 | AGO2,RASGRP4,SPTB,CNKSR1,PAQR3B,SPRED2,PEA15,SPRED1,SPNA1,DUSP9 |
| Cytokine Signaling in Immune system | IL17RD,ARIH1L,RASGRP4,UBE2V1,IRF6,MX2,TRIM14,TNIP2,GBP1,SPRED2 |
| DAP12 signaling | SPTBN2,WDR83,LAMTOR2,FGF18B,FGFR1B,FGF8B,DUSP6,FRS2B,PEA15A,CSF2RB |
| ARMS-mediated activation | CRK,LAMTOR2,NTF7,CSF2RA,SPRED2,CNKSR1,DUSP6,FGF10B,PAQR3B,NRG2A |
| DAP12 interactions | AGO3,CSF2RB,LCP2A,MOV10,RASGRP1,LAMTOR2,SPRED3,PTPRA,GRAP2A,CNKSR1 |
| Axon guidance | CSF2RA,MAPK3,SEMA6A,SPTA1,PAQR3A,SIAH2,RND1,ST8SIA2,SEMA3D,SPRED2 |
Protein Function
DUSP2 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity,mitogen-activated protein kinase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP2 itself. We selected most functions DUSP2 had, and list some proteins which have the same functions with DUSP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine/threonine phosphatase activity | SACM1L,CTDSPL2B,SACM1LB,NT5DC3,TENC1,PXYLP1,DUSP1,DUSP4,SACM1LA,PTPRQ |
| mitogen-activated protein kinase binding | NBR1,MAPKAPK5,ATF7,SIRT1,TPR,TNIP1,ABL1,MAPKAPK2B,MAPKAPK2A,GTF2I |
| protein binding | XPO7,URM1,ZNF256,DDX31,UXT,VEGFC,TRIM22,SULT1A2,PCGF1,SENP7 |
| protein tyrosine/serine/threonine phosphatase activity | DUSP9,DUSP8A,SACM1LB,DUSP3B,DUSP23A,PTP4A2A,DUSP13,SACM1LA,DUSP19B,DUSP5 |
| MAP kinase tyrosine/serine/threonine phosphatase activity | DUSP4,SACM1LA,SGPP2,DUSP16,DUSP1,CTDSPL2A,PXYLP1,DUSP5,DUSP18,DUSP7 |
| protein tyrosine phosphatase activity | DUSP19,MTM1,PTPRFB,CDC14AA,KIAA1274,CDC14AB,DUSP5,MTMR1A,SSH3,MTMR3 |
Interacting Protein
DUSP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP2.
MAPK3;MAPK1
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