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Official Full Name dual specificity phosphatase 2
Background The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily.These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.
Synonyms DUSP2; dual specificity phosphatase 2; dual specificity protein phosphatase 2; PAC 1; Dual specificity protein phosphatase PAC 1; DUSP 2; PAC1; Serine/threonine specific protein phosphatase; OTTHUMP00000161013; dual-specificity phosphatase 2; dual specificity protein phosphatase PAC-1; PAC-1
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DUSP2-101H Recombinant Human DUSP2, GST-tagged Wheat Germ GST
    Human DUSP2-45H Recombinant Human DUSP2 protein, His-tagged E.coli His
    Mouse DUSP2-4883M Recombinant Mouse DUSP2 Protein Mammalian Cell His
    Zebrafish DUSP2-898Z Recombinant Zebrafish DUSP2 Mammalian Cell His

    dusp2 involved in several pathways and played different roles in them. We selected most pathways dusp2 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with dusp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation SPNA2; FRS2A; WDR83; FGF8B; DUSP7; FRS2; DUSP9; CSF2; SPRED2; PSMD5
    Axon guidance Plxna2; GDNF; DCX; CHL1; TRPC3; ACTR3; PLXNA1; LRRC4; CSF2; FYN
    Cytokine Signaling in Immune system EGR1; TNFSF13B; DUSP2; CSHL1; IL1RN; EIF4G1; WDR83; IFI30; KBTBD7; GBP2
    DAP12 interactions PAQR3B; NRG3; CSF2RB; DUSP10; SPRED2; SIGLEC15; PEA15A; SPTB; AHCYL1; FGF18B
    Developmental Biology MYL9; CLTC; COL4A3; SALL4; HELZ2; GDNF; KLB; PSPN; KDR; RND1L
    Downstream signal transduction FRS3; KBTBD7; FRS2B; FRS2A; SPTB; SPRED1; DAB2IPB; SPNA1; CRKL; RASGEF1A
    Downstream signaling of activated FGFR1 SPNA1; SPRED1; DUSP9; PEA15; RASGEF1A; AGO2; PAQR3B; IL17RD; SPRED2; DUSP2

    dusp2 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, mitogen-activated protein kinase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dusp2 itself. We selected most functions dusp2 had, and list some proteins which have the same functions with dusp2. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase tyrosine/serine/threonine phosphatase activity SACM1LA; CTDSPL2B; NT5DC3; TENC1; SACM1L; SACM1LB; DUSP16; DUSP14; PTPRQ; DUSP10
    mitogen-activated protein kinase binding SIRT1; PTPRJ; TNIP1; ABL1; TPR; MAPKAPK5; GTF2I; MAPKAPK2; CDK5RAP3; EP300
    protein binding DDX41; PES1; THSD4; DNAJC11; CHRM3; UXT; CST1; PNRC2; RBM6; UBE2Q1
    protein tyrosine phosphatase activity PTPN11B; EYA3; UBASH3B; PTPN22; MTMR7A; PTPN4A; PTPN3; MTMR4; SSH2B; CDKN3
    protein tyrosine/serine/threonine phosphatase activity DUSP13A; DUSP19A; PTEN; DUSP10; LRP8; EYA3; CDC14C; TPTE; PXYLP1; CTDSPL2A
    protein tyrosine/threonine phosphatase activity DUSP1; TENC1; PXYLP1; DUSP19; DUSP4; SGPP2; DUSP2; SACM1LA; SACM1LB; SACM1L

    dusp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dusp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of dusp2.

    MAPK3; MAPK1

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