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Official Full Name dual specificity phosphatase 4
Background The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
Synonyms DUSP4; dual specificity phosphatase 4; dual specificity protein phosphatase 4; HVH2; MAP kinase phosphatase 2; MKP 2; TYP; VH1 homologous phosphatase 2; dual specificity protein phosphatase hVH2; serine/threonine specific protein phosphatase; mitogen-acti
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DUSP4-101H Recombinant Human DUSP4, GST-tagged Wheat Germ GST
    Human DUSP4-1041H Recombinant Human DUSP4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human DUSP4-2919H Recombinant Human DUSP4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human DUSP4-6773HCL Recombinant Human DUSP4 293 Cell Lysate HEK293 N/A
    Human DUSP4-6774HCL Recombinant Human DUSP4 293 Cell Lysate HEK293 N/A
    Mouse Dusp4-2690M Recombinant Mouse Dusp4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse DUSP4-4890M Recombinant Mouse DUSP4 Protein Mammalian Cell His
    Rat DUSP4-1976R Recombinant Rat DUSP4 Protein Mammalian Cell His
    Chicken DUSP4-6401C Recombinant Chicken DUSP4 Mammalian Cell His
    Zebrafish DUSP4-11388Z Recombinant Zebrafish DUSP4 Mammalian Cell His

    DUSP4 involved in several pathways and played different roles in them. We selected most pathways DUSP4 participated on our site, such as ARMS-mediated activation, Activated TLR4 signalling, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation FRS2; NRG2A; CRK; NEFLB; DLG4; PSMD5; KIDINS220B; SLC14A2; FGFR1B; NRG4
    Activated TLR4 signalling DUSP7; CREB1B; TIRAP; CHUK; MAPKAPK2B; DHX9; PELI2; AGER; S100A12; PELI3
    Axon guidance LIMK1; DPYSL5; UNC5A; CSF2; CLTA; TRPC3; EGF; MYL12A; FGF18B; CSNK2B
    B Cell Receptor Signaling Pathway PLEKHA2; INPP5D; AKT2; CD79A; AKT1; PRKCB; IKBKB; LILRB3; NFKB1; PPP3CC
    Cytokine Signaling in Immune system IFI30; NOD1; TNFRSF13C; IRF2; CSF2; EDA; HBEGF; PAQR3A; DUSP9; NRG4
    DAP12 interactions THEM4; CLEC5A; AHCYL1; CSF2RB; GRAP2A; AGO2; JAK3; SPNA1; DUSP6; SIGLEC14
    DAP12 signaling CSF2RA; NRG4; DUSP10; DUSP4; NRG2A; PTPRA; DUSP7; FRS3; TRAT1; DUSP2
    Developmental Biology RASGRP1; NADL1.1; ARPC3; FOXH1; CTNNA2; CAP2; FGF20A; KIF4; DCC; COL4A3

    DUSP4 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP4 itself. We selected most functions DUSP4 had, and list some proteins which have the same functions with DUSP4. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase tyrosine/serine/threonine phosphatase activity DUSP9; CTDSPL2A; CTDSPL2B; SGPP2; DUSP2; DUSP14; DUSP21; DUSP1; DUSP5; SACM1LB
    protein tyrosine phosphatase activity CDC25A; MTM1; DUSP15; PTEN; PGP; EPM2A; LRP8; PTPN11; CDC14B; PTP4A2B
    protein tyrosine/serine/threonine phosphatase activity DUSP15; CDKN3; DUSP3B; DUSP23A; SSH2; PTPMT1; CTDSPL2A; CDC14C; EYA3; PTP4A2B
    protein tyrosine/threonine phosphatase activity PXYLP1; NT5DC3; DUSP19; TENC1; CTDSPL2A; SACM1L; DUSP2; SGPP2; PTPRQ; DUSP4

    DUSP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP4.


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