DUSP4
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Official Full Name
dual specificity phosphatase 4
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Overview
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. -
Synonyms
DUSP4; dual specificity phosphatase 4; dual specificity protein phosphatase 4; HVH2; MAP kinase phosphatase 2; MKP 2; TYP; VH1 homologous phosphatase 2; dual specificity protein phosphatase hVH2; serine/threonine specific protein phosphatase; mitogen-acti;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insects cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
DUSP4 involved in several pathways and played different roles in them. We selected most pathways DUSP4 participated on our site, such as ARMS-mediated activation, Activated TLR4 signalling, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ARMS-mediated activation | CSF2;DAB2IPB;DUSP1;SPNA1;PSMD10;SPTA1;JAK3;MARK3;SLC14A2 |
| Activated TLR4 signalling | DUSP3B;CHST13;PELI1;TNIP2;SIGIRR;CREB1;UBE2V1;DUSP3;ALCAMB |
| Axon guidance | UNC5A;ABLIM1;ITGB3A;PPP3CB;FYN;RGMB;KIF4A;CD24;SPRED1 |
| B Cell Receptor Signaling Pathway | CD19;CD81;PDK2;VAV1;FCGR2B;MAP4K1;PIK3R5;NFKBIA;STAP1 |
| Cytokine Signaling in Immune system | SPRED2;EIF4G2;EIF4E3;TRIM10;EDA;HAVCR2;TNFRSF13C;IFIT10;ISG20 |
| DAP12 interactions | THEM4;KLB;PEA15;NEFLB;SPTB;CD300LB;NRG2A;FGF20A;KIR3DS1 |
| DAP12 signaling | KBTBD7;DUSP1;FGF10B;LAMTOR2;SPRED3;IL17RD;WDR83;NRG4;SPRED2 |
| Developmental Biology | MED21;MED10;MED22;CLASP1;SCN3A;KIF4;NRG2A;PAQR3A;KALRN |
DUSP4 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP4 itself. We selected most functions DUSP4 had, and list some proteins which have the same functions with DUSP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MAP kinase tyrosine/serine/threonine phosphatase activity | PXYLP1;DUSP4;DUSP9;DUSP16;DUSP1;DUSP18;DUSP14;DUSP8A;DUSP6 |
| protein tyrosine phosphatase activity | EVLA;PTPDC1;CDC25A;DUSP28;DUSP22;DUPD1;PTPRJA;CDC25B;RNGTT |
| protein tyrosine/serine/threonine phosphatase activity | DUSP10;CDKN3;CDC14A;DUSP13A;PTENA;DUSP2;CDC14C;DUSP22B;PTP4A3 |
| protein tyrosine/threonine phosphatase activity | PTPRQ;DUSP1;DUSP4;TENC1;SACM1LA;DUSP19;NT5DC3;PXYLP1;SACM1LB |
DUSP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP4.
MAPK1; MAPK9; MAPK8; MAPK14; CRMP1; MAPK1
- Q&As
- Reviews
Q&As (5)
Ask a questionDUSP4 inactivates MAPKs by dephosphorylating them and thus performs an important function in the MAPK signaling pathway
DUSP4 also known as mitogen-activated protein kinase phosphatase 2
You can choose PVDF membrane.
DUSP4 is involved in diseases such as laryngeal, breast and colorectal cancer
In colon cancer, overexpression of DUSP4 may lead to increased proliferation of tumor cells through stimulation of growth-promoting genes such as Myc and cell cycle protein D1
Customer Reviews (3)
Write a reviewThe protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.
Very good after-sales service to get my experiments going!
The technician modified my experimental protocol so that my experiment went smoothly.
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