EDA

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EDA

Official Full Name ectodysplasin A
Background The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
Synonyms EDA; ectodysplasin A; ectodermal dysplasia 1, anhidrotic , ED1, EDA2, ODT1, oligodontia 1; ectodysplasin-A; ED1 A1; ED1 A2; EDA1; HED; XHED; XLHED; oligodontia 1; ectodermal dysplasia protein; X-linked anhidroitic ectodermal dysplasia protein; ED1; EDA2; ODT1; ED1-A1; ED1-A2; STHAGX1
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human cells
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Flag
    • His
    • StrepII
    • GST
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EDA-2082H Recombinant Human Ectodysplasin A, FLAG-tagged HEK293 Flag
    Human EDA-2117H Recombinant Human Ectodysplasin A, FLAG-tagged E.coli Flag
    Human EDA-260H Recombinant Human EDA Mammalian cells N/A
    Human EDA-3041H Recombinant Human EDA Protein, His/Flag/StrepII-tagged Human cells His/Flag/StrepII
    Human EDA-4269H Recombinant Human EDA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EDA-928H Recombinant Human EDA Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Eda-2722M Recombinant Mouse Eda Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse EDA-4979M Recombinant Mouse EDA Protein Mammalian Cell His
    Mouse Eda-693M Recombinant Mouse Eda Protein, His/GST-tagged E.coli His/GST
    Mouse Eda-979M Recombinant Mouse Eda Protein, His-tagged Mammalian cells His
    Zebrafish EDA-6523Z Recombinant Zebrafish EDA Mammalian Cell His

    EDA involved in several pathways and played different roles in them. We selected most pathways EDA participated on our site, such as Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system CSHL1; EIF4G2; HLA-DQB2; SPTBN2; RASGRP4; EIF4A1; PELI2; PAQR3B; NRG2A; SPNA1
    Cytokine-cytokine receptor interaction IL20RB; IL2RG; IL1B; CCL24; BMPR1A; CXCL9; BMPR1B; Ccl27a; IL25; ACKR3B
    Immune System LGALS3; RACGAP1; EDAR; DEFB119; PANX1; ERAP2; POLR3C; CLEC2H; KIF26A; SIGLEC5
    TNFR2 non-canonical NF-kB pathway EDARADD; EDAR; EDA
    TNFs bind their physiological receptors EDA; EDAR; EDARADD

    EDA has several biochemical functions, for example, protein binding, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDA itself. We selected most functions EDA had, and list some proteins which have the same functions with EDA. You can find most of the proteins on our site.

    Function Related Protein
    protein binding HSPA14; CHRDL2; NTF3; C9orf86; TULP1; ZHX1; E4F1; C14orf135; NEDD4L; STX2
    receptor binding TAC4; ANGPTL1; FGF18B; BMP3; Itga10&Itgb1; PTPRD; C1QTNF2; A2M; PARK7; TMED1
    tumor necrosis factor receptor binding TNFSF9; TNFSF10L; EDA; BRE; TNFSF10; TRIM37; TNFSF14; CASP8; TNF; TRAF3

    EDA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDA here. Most of them are supplied by our site. Hope this information will be useful for your research of EDA.

    MAL; PLN; ATP6V0C; CYB561; EMP3; LEPROTL1; NIPAL3

    Prasanna, RR; Kamalanathan, AS; et al. Development of L-histidine immobilized CIM (R) monolithic disks for purification of immunoglobulin G. JOURNAL OF MOLECULAR RECOGNITION 28:129-141(2015).
    Kowalczyk-Quintas, C; Schuepbach-Mallepell, S; et al. Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:359-368(2015).

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