EIF4A1
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Official Full Name
eukaryotic translation initiation factor 4A1 -
Overview
A variety of factors contribute to the important biological event of initiation of translation. The eIF4F complex of translation initiation factors binds to the 5 m7 GTP cap to open up the mRNA secondary structure and allow small ribosome subunit binding. -
Synonyms
EIF4A1;eukaryotic translation initiation factor 4A1;EIF4A, eukaryotic translation initiation factor 4A, isoform 1;eukaryotic initiation factor 4A-I;DDX2A;EIF 4A;eukaryotic initiation factor 4AI;ATP-dependent RNA helicase eIF4A-1;eukaryotic transl
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- E.coli
- HEK293
- Yeast
- Wheat Germ
- Mammalian Cells
- In Vitro Cell Free System
- His
- T7
- DDK
- Myc
- Non
- GST
- Strep
- Avi
- Fc
- Flag
Involved Pathway
EIF4A1 involved in several pathways and played different roles in them. We selected most pathways EIF4A1 participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,Antiviral mechanism by IFN-stimulated genes,Cap-dependent Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | IRF2,FRS3,SPRED2,DUSP6,CSHL1,CRKL,TRIM38,TRIM8,NOD1,GBP4 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | EIF4H,EIF4G1,EIF4EB,EIF4B,EIF1AX,EIF1AXA,EIF4E,EIF4A2,FAUB,EIF4EBP1 |
| Deadenylation-dependent mRNA decay | NT5C3B,TNKS1BP1,DCP1B,D1BWG0212E,LSM6,PAIP1,C2orf29,EIF4G1,EIF4E,EXOSC8 |
| Antiviral mechanism by IFN-stimulated genes | EIF4G1,IFIT10,NUPL2,EIF4EB,ARIH1L,JAK1,KPNA4,EIF4G2A,ARIH1,IFIT11 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | EIF2S1,RPL35,EIF4A2,EIF1AX,EIF5,EIF4B,EIF3K,EIF4H,FAUB,EIF2S1A |
| Cap-dependent Translation Initiation | EIF1AX,EIF5,FAUB,EIF4A2,EIF3K,EIF4EB,EIF4G1,EIF2S3,EIF4EBP1,EIF2S1A |
| Eukaryotic Translation Initiation | EIF1AX,EIF2S3,RPL35,EIF4B,EIF2S1A,EIF2B1,EIF4G1,EIF3K,FAUB,EIF2S1 |
| Deadenylation of mRNA | D1BWG0212E,EIF4B,PAIP1,EIF4EB,TNKS1BP1,EIF4A2,EIF4E,EIF4G1,C2orf29 |
Protein Function
EIF4A1 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,RNA cap binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4A1 itself. We selected most functions EIF4A1 had, and list some proteins which have the same functions with EIF4A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded RNA binding | AGO2,ADARB1,RNASEN,DHX58,ZNF346,EIF2AK2,LRRFIP1,OAS1A,TLR3,DHX15 |
| ATP-dependent RNA helicase activity | DDX6,SUPV3L1,DDX19A,DDX19B,DDX25,DDX20,G3BP1,DDX39A,DDX4,DHX30 |
| translation initiation factor activity | EIF1AXB,EIF4E2RS1,EIF1AY,EIF3F,EIF4E3,EIF1AD,EIF1,EIF4G1,EIF3E,EIF4H |
| ATP binding | HSPA13,MKNK2A,ICK,TK2,GATB,CFTR,NEK5,CAMK2B,AKT3A,ACSM5 |
| helicase activity | GTF2F2A,HELQ,EIF4A2,DDX39,EIF4A1A,RAD54L,TDRD12,SNRNP200,MOV10B.1,PL10 |
| translation factor activity, RNA binding | EIF4G1,EIF1,CPEB3,EIF5,MTIF3,CPEB1B,GTF2H3,PPP1R2P9,EEF1A2,SOX11 |
| mRNA binding | SOSTDC1B,THOC2,RPL13A,IGF2BP2A,PARK7,RBM5,CSTF3,PTBP2,FXR2,EIF4ENIF1 |
| poly(A) RNA binding | WBSCR22,RRP1,RTCD1,RALYL,DDX52,RDBP,ZNF622,SBDS,MRPL37,DDX55 |
| RNA cap binding | EIF4E2,EIF4G3,EIF4E,NCBP1,NCBP2,LARP1,SNUPN |
Interacting Protein
EIF4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4A1.
EIF4G1;EIF4G2;PDCD4;Eif3a;EIF4H
EIF4A1 Related Signal Pathway
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References
- Stoneley, M; Willis, AE; et al. eIF4A1 is a promising new therapeutic target in ER-negative breast cancer. CELL DEATH AND DIFFERENTIATION 22:524-525(2015).
