|Official Full Name||eukaryotic translation initiation factor 4A2|
|Background||Eukaryotic initiation factor 4A plays an important role in the binding of mRNA to the 43S preinitiation complex when protein synthesis begins. Two highly homologous forms of functional EIF4A genes, Eif4a1 and Eif4a2, have been isolated in mice; yeast cells also possess 2 EIF4A genes, TIF1 and TIF2. The murine Eif4a and yeast TIF genes appear to belong to a DEAD-box gene family, whose members exhibit extensive amino acid similarity and contain the asp-glu-ala-asp (DEAD) sequence. DEAD-box genes have been identified in species ranging from E-coli to humans. Their function appears to be related to transcriptional/translational regulation (referenced from OMIM).|
|Synonyms||EIF4A2; eukaryotic translation initiation factor 4A2; DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II; eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase eIF4A-2; eukaryotic translation initiation factor 4A, isoform 2;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
eif4a2 involved in several pathways and played different roles in them. We selected most pathways eif4a2 participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with eif4a2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S||EIF2S3; EIF4E; EIF1AX; EIF4A2; EIF3K; EIF1AXA; EIF4B; EIF4G1; EIF2S1A; EIF4H|
|Antiviral mechanism by IFN-stimulated genes||ARIH1; IFIT11; KPNA5; EIF4G1; MX2; DPF1; HERC5; IFIT12; EIF4G2A; IFIT14|
|Cap-dependent Translation Initiation||EIF4EB; EIF4EBP1; EIF4B; FAUB; EIF4G1; EIF2S3; EIF2S1; EIF4E; EIF1AX; EIF5|
|Cytokine Signaling in Immune system||PHB; IFIT2; IFITM2; EIF4G1; IFIT10; TRIM17; DUSP2; DUSP5; EIF4EB; SPTBN2|
|Deadenylation of mRNA||EIF4A2; TNKS1BP1; EIF4EB; PAIP1; EIF4B; C2orf29; EIF4G1; EIF4E; EIF4A1; D1BWG0212E|
|Deadenylation-dependent mRNA decay||DDX6; EIF4E; EIF4A2; NT5C3B; PAIP1; EXOSC8; TNKS1BP1; LSM6; C2orf29; DCP2|
|Eukaryotic Translation Initiation||EIF3K; EIF2S3; EIF4H; EIF2S1A; EIF4A1; EIF1AXA; RPL35; EIF4G1; EIF4B; EIF2B1|
|GTP hydrolysis and joining of the 60S ribosomal subunit||EIF2S3; EIF5; EIF4A1; EIF3K; EIF1AX; EIF4B; EIF2S1A; FAUB; EIF4A2; EIF2S1|
eif4a2 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by eif4a2 itself. We selected most functions eif4a2 had, and list some proteins which have the same functions with eif4a2. You can find most of the proteins on our site.
|ATP binding||PGK2; MAGI1; CDK5; PRKCQ; PLK3; RPS6KC1; UBE2E3; STK40; INSRR; STK35|
|ATP-dependent RNA helicase activity||CHST13; ACTG2; DDX41; BAT1; DHX16; DDX4; DDX10; DDX39B; DDX59; DDX47|
|ATPase activity||KIF20B; MACF1; ABCA1B; ATP13A; MLH1; EIF4A1A; ABCA4; VPS4B; ABCB6A; KIF22|
|helicase activity||SETX; GTF2F2A; PL10; DHX34; MOV10; RAD54L; ANXA1; HLTF; WRN; CHD6|
|poly(A) RNA binding||C22orf28; SND1; RPL10A; PUF60; PRKDC; OASL; MTERF; XPO5; ACTN4; SMC1A|
|protein binding||UBE2B; GLA; WAS; MED23; PRDM14; DNPEP; DNMT3A; BTG2; PSMD4; PPP1R1A|
|translation initiation factor activity||EIF2S1A; EIF4A2; MTIF2; EIF4E2; EIF2A; EIF4A1B; EIF1AX; MTIF3; EIF2S3; EIF3F|
eif4a2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with eif4a2 here. Most of them are supplied by our site. Hope this information will be useful for your research of eif4a2.
PDCD4; p27958-pro_0000037577; EIF4G1; EIF3H; EIF4G2; DPPA4