EPHA3

  • Official Full Name

    EPH receptor A3

  • Background

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal andhippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
  • Synonyms

    EPHA3; EPH receptor A3; EphA3 , ETK, ETK1, TYRO4; ephrin type-A receptor 3; HEK; HEK4; EPH-like kinase 4; human embryo kinase 1; eph-like tyrosine kinase 1; TYRO4 protein tyrosine kinase; tyrosine-protein kinase receptor ETK1; EK4; ETK; ETK1; TYRO4;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Insect Cells
    • Mammalian cell
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • DDK|His
    • Fc
    • Fc|His
    • Gly
    • Pro
    • GST
    • GST|His
    • hFc
    • His
    • His (Fc)
    • Avi
    • MYC
    • Myc|DDK
    • N/A
    • No tag
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken EPHA3-6981C Recombinant Chicken EPHA3 Mammalian Cell His
    Human EPHA3-363H Recombinant Human EPHA3 Protein, DDK/His-tagged HEK293 DDK/His
    Human EPHA3-1880H Recombinant Human EPH Receptor A3, His-tagged E.coli His
    Human EPHA3-301H Recombinant Human EPH Receptor A3, GST-tagged, Active Sf9 Insect Cell GST
    Human EPHA3-66H Recombinant Human EPHA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human EPHA3-364H Recombinant Human EPHA3 Protein, DDK-tagged Insect Cell DDK
    Human EPHA3-26440TH Recombinant Human EPHA3 N/A
    Human EPHA3-1218HCL Recombinant Human EPHA3 cell lysate Human Cell N/A
    Human EPHA3-559H Active Recombinant Human EPHA3 Protein, Fc Chimera Mammalian cells Fc
    Human EPHA3-8547HAF555 Recombinant Human EPHA3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Human EPHA3-8547H Recombinant Human EPHA3, His tagged Human Cell Fc/His
    Human EPHA3-365H Recombinant Human EPHA3 Protein, DDK/His-tagged HEK293 DDK/His
    Human EPHA3-3380H Recombinant Human EPHA3 Protein, GST/His-tagged Insect Cell GST/His
    Human EPHA3-8547HAF647 Recombinant Human EPHA3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Human EPHA3-1901H Recombinant Human EPHA3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EPHA3-0984H Recombinant Human EPHA3 Protein (K579-V983), GST tagged Insect Cell GST
    Human EPHA3-3381H Recombinant Human EPHA3 Protein, GST-tagged Insect Cell GST
    Human EPHA3-8547HF Recombinant Human EPHA3 Protein, His-tagged, FITC conjugated HEK293 His
    Human EPHA3-4236H Active Recombinant Human EPHA3 protein, His-tagged Mammalian cell His
    Human EPHA3-66H-B Recombinant Human EPHA3 Protein Pre-coupled Magnetic Beads HEK293
    Human EPHA3-3382H Recombinant Human EPHA3 Protein, GST-tagged Wheat Germ GST
    Human EPHA3-0983H Recombinant Human EPHA3 Protein (K579-V983), Tag Free Insect Cell No tag
    Human EPHA3-8547HAF488 Recombinant Human EPHA3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Human EPHA3-2697H Recombinant Human EPHA3 protein, hFc&His-tagged HEK293 hFc&His
    Mouse Epha3-10542M Recombinant Mouse Epha3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse EPHA3-180MAF555 Recombinant Mouse Epha3 Protein, His-GST-tagged, Alexa Fluor 555 conjugated Insect Cell His/GST
    Mouse EPHA3-180MAF488 Recombinant Mouse Epha3 Protein, His-GST-tagged, Alexa Fluor 488 conjugated Insect Cell His/GST
    Mouse Epha3-10542M-B Recombinant Mouse Epha3 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Epha3-493MAF647 Recombinant Mouse Epha3 Protein, Gly/Pro-tagged, Alexa Fluor 647 conjugated Insect Cell Gly/Pro
    Mouse EPHA3-180MAF647 Recombinant Mouse Epha3 Protein, His-GST-tagged, Alexa Fluor 647 conjugated Insect Cell His/GST
    Mouse Epha3-493MAF488 Recombinant Mouse Epha3 Protein, Gly/Pro-tagged, Alexa Fluor 488 conjugated Insect Cell Gly/Pro
    Mouse EphA3-2212M Recombinant Mouse EphA3 protein, His&GST-tagged Insect Cells His/GST
    Mouse Epha3-495MAF647 Recombinant Mouse Epha3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Mouse EPHA3-180MF Recombinant Mouse Epha3 Protein, His-GST-tagged, FITC conjugated Insect Cell His/GST
    Mouse Epha3-494MAF488 Active Recombinant Mouse Epha3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Mouse Epha3-493MF Recombinant Mouse Epha3 Protein, Gly/Pro-tagged, FITC conjugated Insect Cell Gly/Pro
    Mouse Epha3-494MF Active Recombinant Mouse Epha3 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Mouse EPHA3-002MCL Recombinant Mouse EPHA3 cell lysate Insect Cell N/A
    Mouse Epha3-495MAF488 Recombinant Mouse Epha3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Mouse Epha3-495MF Recombinant Mouse Epha3 Protein, His-tagged, FITC conjugated HEK293 His
    Mouse Epha3-494MAF555 Active Recombinant Mouse Epha3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Mouse Epha3-494M Active Recombinant Mouse Epha3, Fc-tagged Human Cell Fc
    Mouse Epha3-493M Recombinant Mouse Epha3 Insect Cell N/A
    Mouse Epha3-493MAF555 Recombinant Mouse Epha3 Protein, Gly/Pro-tagged, Alexa Fluor 555 conjugated Insect Cell Gly/Pro
    Mouse Epha3-495M Recombinant Mouse Epha3, His-tagged Human Cell His
    Mouse Epha3-495MAF555 Recombinant Mouse Epha3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Mouse Epha3-494MAF647 Active Recombinant Mouse Epha3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Mouse Epha3-955M Recombinant Mouse Epha3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Epha3-1723M Recombinant Mouse Eph Receptor A3 Mammalian cells N/A
    Mouse EPHA3-001MCL Recombinant Mouse EPHA3 cell lysate Human Cell N/A
    Mouse EPHA3-180M Recombinant Mouse Epha3, His-GST tagged Insect Cell Fc/His
    Rat Epha3-552RAF555 Recombinant Rat Epha3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Rat Epha3-551RAF488 Active Recombinant Rat Epha3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Rat EPHA3-001RCL Recombinant Rat EPHA3 cell lysate Human Cell N/A
    Rat Epha3-551RAF647 Active Recombinant Rat Epha3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Rat Epha3-552RAF647 Recombinant Rat Epha3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Rat Epha3-551RAF555 Active Recombinant Rat Epha3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Rat Epha3-551R Active Recombinant Rat Epha3, Fc-tagged Human Cell Fc
    Rat Epha3-552RAF488 Recombinant Rat Epha3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Rat Epha3-552R Recombinant Rat Epha3, His-tagged Human Cell His
    Rat Epha3-551RF Active Recombinant Rat Epha3 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Rat Epha3-552RF Recombinant Rat Epha3 Protein, His-tagged, FITC conjugated HEK293 His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • EPHA3 Related Articles

    EPHA3 involved in several pathways and played different roles in them. We selected most pathways EPHA3 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPHA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidanceCSNK2A2;GNAI2;GSK3B;PPP3R1;SEMA5A;SPRED3;PSPN;NFATC2;PITPNA

    EPHA3 has several biochemical functions, for example, ATP binding, GPI-linked ephrin receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPHA3 itself. We selected most functions EPHA3 had, and list some proteins which have the same functions with EPHA3. You can find most of the proteins on our site.

    Function Related Protein
    ATP bindingUBE2L3;PIM3;HSPA12A;NLRX1;OXSR1B;MAST4;MAPK8;FDXACB1;MARK2
    GPI-linked ephrin receptor activityEPHA8;EPHA7;EPHA4;EK1;EPHA5;EPHA3
    protein bindingPBLD;EGLN1;CDC25C;IFT20;MAPK15;BRAP;DDO;POU5F1;EREG

    EPHA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPHA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPHA3.

    ephopt; optyf; EPHA7; SRPK1; RBM18; CDKN2A; RUFY1

    Swords, RT; Wei, AH; et al. KB004, a Novel Non-Fucosylated Humaneered (R) Antibody, Targeting EphA3, Is Active and Well Tolerated in a Phase I/II Study of Advanced Hematologic Malignancies. BLOOD 124:-(2014).
    Tomasevic, N; Luehrsen, K; et al. A high affinity recombinant antibody to the human EphA3 receptor with enhanced ADCC activity. GROWTH FACTORS 32:223-235(2014).
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