Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal andhippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
EPHA3 involved in several pathways and played different roles in them. We selected most pathways EPHA3 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPHA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
EPHA3 has several biochemical functions, for example, ATP binding, GPI-linked ephrin receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPHA3 itself. We selected most functions EPHA3 had, and list some proteins which have the same functions with EPHA3. You can find most of the proteins on our site.
EPHA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPHA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPHA3.
ephopt; optyf; EPHA7; SRPK1; RBM18; CDKN2A; RUFY1
Swords, RT; Wei, AH; et al. KB004, a Novel Non-Fucosylated Humaneered (R) Antibody, Targeting EphA3, Is Active and Well Tolerated in a Phase I/II Study of Advanced Hematologic Malignancies. BLOOD 124:-(2014).
Tomasevic, N; Luehrsen, K; et al. A high affinity recombinant antibody to the human EphA3 receptor with enhanced ADCC activity. GROWTH FACTORS 32:223-235(2014).