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Official Full Name EPH receptor B3
Background Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members.
Synonyms EPHB3; EPH receptor B3; EphB3 , ETK2; ephrin type-B receptor 3; Hek2; Tyro6; EK2; EPH-like kinase 2; embryonic kinase 2; human embryo kinase 2; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; tyrosine-protein kinase TYRO6; ETK2
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NSO
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • GST
    • T7
    • MYC/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EPHB3-001HCL Recombinant Human EPHB3 cell lysate Insect Cell N/A
    Human EPHB3-1214H Recombinant Human EPH Receptor B3, GST-tagged Insect Cell GST
    Human EPHB3-1900H Recombinant Human EPHB3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EPHB3-28578TH Recombinant Human EPHB3 N/A
    Human EPHB3-305H Recombinant Human EPH Receptor B3, GST-tagged, Active Sf9 Insect Cell GST
    Human EPHB3-3401H Recombinant Human EPHB3 Protein, GST-tagged Wheat Germ GST
    Human EPHB3-376H Recombinant Human EPHB3 Protein, DDK/His-tagged HEK293 DDK/His
    Human EPHB3-377H Recombinant Human EPHB3 Protein, DDK-tagged Insect Cell DDK
    Human EPHB3-563H Recombinant Human EPHB3 Mammalian Cell His
    Human EPHB3-6641H Recombinant Human EPHB3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EPHB3-8627H Recombinant Human EPHB3, His & GST tagged Insect Cell His/GST
    Mouse Ephb3-1135M Recombinant Mouse Ephb3 protein, His & T7-tagged E.coli His/T7
    Mouse Ephb3-1728M Recombinant Mouse Eph Receptor B3 NSO N/A
    Mouse EPHB3-2131MCL Recombinant Mouse EPHB3 cell lysate Human Cell N/A
    Mouse Ephb3-4051M Recombinant Mouse Ephb3, His tagged Human Cell His
    Mouse Ephb3-957M Recombinant Mouse Ephb3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat Ephb3-1160R Recombinant Rat Ephb3 Protein, His-tagged HEK293 His
    Kit-1555 U2OS EphB3 Bioassay Kit N/A
    Kit-1584 EphB3 Functional Assay Kit N/A

    ephb3 involved in several pathways and played different roles in them. We selected most pathways ephb3 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ephb3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance TRPC4; JAK1; ROBO1; CSF2RB; DPYSL2; FRS2B; PAK7; KBTBD7; EPHB3; RHOA

    ephb3 has several biochemical functions, for example, ATP binding, axon guidance receptor activity, ephrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ephb3 itself. We selected most functions ephb3 had, and list some proteins which have the same functions with ephb3. You can find most of the proteins on our site.

    Function Related Protein
    axon guidance receptor activity EPHA7; GFRA3; EPHB3; SEMA5A; ROBO2; EPHB1; ROBO1
    ephrin receptor activity EPHA2; EPHA2A; EPHB3A; EPHB2B; EK1; EPHA5; EPHB4; EPHB6; EPHA4B; EPHA10

    ephb3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ephb3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ephb3.

    npm_alk; saicar; PKM; MLLT4; GBE1; NFRKB; purvalanol b

    Ronsch, K; Jagle, S; et al. SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. MOLECULAR ONCOLOGY 9:335-354(2015).
    McLaughlin, T; Lim, YS; et al. Multiple EphB receptors mediate dorsal-ventral retinotopic mapping via similar bi-functional responses to ephrin-B1. MOLECULAR AND CELLULAR NEUROSCIENCE 63:24-30(2014).

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