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Ephb3

  • Official Full Name

    EPH receptor B3

  • Overview

    Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members.
  • Synonyms

    EPHB3; EPH receptor B3; EphB3 , ETK2; ephrin type-B receptor 3; Hek2; Tyro6; EK2; EPH-like kinase 2; embryonic kinase 2; human embryo kinase 2; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; tyrosine-protein kinase TYRO6; ETK2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • Fc
  • 6×His
  • His
  • DDK
  • DDK|His
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • MYC
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EPHB3-74H Active Recombinant Human EPHB3(599-920) Protein, N-His-tagged Sf21 His 599-920 aa
Human EPHB3-1214H Recombinant Human EPH Receptor B3, GST-tagged Insect Cell GST
Human EPHB3-377H Recombinant Human EPHB3 Protein, DDK-tagged Insect Cell DDK Met-Gly34-Leu559
Human EPHB3-376H Recombinant Human EPHB3 Protein, DDK/His-tagged HEK293 DDK/His Gly34-Leu559
Human EPHB3-28578TH Recombinant Human EPHB3 N/A
Human EPHB3-3401H Recombinant Human EPHB3 Protein, GST-tagged Wheat Germ GST
Human EPHB3-563H Recombinant Human EPHB3 Mammalian Cell His
Human EPHB3-305H Recombinant Human EPH Receptor B3, GST-tagged, Active Sf9 Insect Cell GST
Human EPHB3-8627H Recombinant Human EPHB3, His & GST tagged Insect Cell His/GST
Human EPHB3-001HCL Recombinant Human EPHB3 cell lysate Insect Cell N/A
Human EPHB3-0992H Recombinant Human EPHB3 Protein (A2-V998), GST tagged Insect Cell GST A2-V998
Human EPHB3-1900H Recombinant Human EPHB3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EPHB3-6641H Recombinant Human EPHB3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EPHB3-0991H Recombinant Human EPHB3 Protein (A2-V998), Tag Free Insect Cell No tag A2-V998
Human EPHB3-4368HF Recombinant Full Length Human EPHB3 Protein, GST-tagged In Vitro Cell Free System GST 998 amino acids
Human EPHB3-2871H-B Recombinant Human EPHB3 Protein Pre-coupled Magnetic Beads HEK293
Human EPHB3-2871H Recombinant Human EPHB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EPHB3-30H Active Recombinant Human EPHB3 Protein (Leu38-Ala550), Fc tagged NS0 Fc Leu38-Ala550
Mouse Ephb3-1135M Recombinant Mouse Ephb3 protein, His & T7-tagged E.coli His/T7 Val628~Ile891 (Accession # P54754)
Mouse Ephb3-4051M Active Recombinant Mouse Ephb3 protein(Met1-Thr537), His-tagged HEK293 C-His Met1-Thr537
Mouse Ephb3-1728M Recombinant Mouse Eph Receptor B3 Mammalian cells N/A
Mouse EPHB3-2131MCL Recombinant Mouse EPHB3 cell lysate Human Cell N/A
Mouse Ephb3-957M Recombinant Mouse Ephb3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Ephb3-10547M Recombinant Mouse Ephb3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ephb3-10547M-B Recombinant Mouse Ephb3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ephb3-29M Active Recombinant Mouse EphB3 Protein (Leu30-Thr537), C-Fc and 6×His tagged NS0 C-Fc and 6×His Leu30-Thr537
Rat Ephb3-1160R Active Recombinant Rat Ephb3 Protein, His-tagged HEK293 His
Kit-1584 EphB3 Functional Assay Kit N/A
Kit-1555 U2OS EphB3 Bioassay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Ephb3 Related Articles

Ephb3 involved in several pathways and played different roles in them. We selected most pathways Ephb3 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ephb3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceSCN2B;MAPK1;EPHB3A;ITGB3A;LRRC4C;PAK7;UNC5C;ARPC5;FGF8B

Ephb3 has several biochemical functions, for example, ATP binding, axon guidance receptor activity, ephrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ephb3 itself. We selected most functions Ephb3 had, and list some proteins which have the same functions with Ephb3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSHPK;UBE2E1;CAMK2B;PDS5B;RIPK4;PDK1;KTI12;EPHA4B;CDK8
axon guidance receptor activityROBO1;SEMA5A;EPHB3;ROBO2;GFRA3;EPHA7;EPHB1
ephrin receptor activityEPHA6;EPHA2A;EPHA10;EPHB4A;EPHB6;EPHB4B;EK1;EPHA4B;EPHB4

Ephb3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ephb3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ephb3.

npm_alk; saicar; PKM; MLLT4; GBE1; NFRKB; purvalanol b

Ronsch, K; Jagle, S; et al. SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. MOLECULAR ONCOLOGY 9:335-354(2015).
McLaughlin, T; Lim, YS; et al. Multiple EphB receptors mediate dorsal-ventral retinotopic mapping via similar bi-functional responses to ephrin-B1. MOLECULAR AND CELLULAR NEUROSCIENCE 63:24-30(2014).
  • Q&As
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