EPS8
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Official Full Name
epidermal growth factor receptor pathway substrate 8 -
Overview
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. -
Synonyms
EPS8;epidermal growth factor receptor pathway substrate 8;epidermal growth factor receptor kinase substrate 8
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
EPS8 involved in several pathways and played different roles in them. We selected most pathways EPS8 participated on our site, such as CDC42 signaling events,EGFR1 Signaling Pathway,ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EGFR1 Signaling Pathway | GRB10,RGS5B,ZNF259,KRT17,USP6NL,TNK2,WNK1,RBB4L,SH3BGRL,RGS16 |
| ErbB1 downstream signaling | EGR1,ABI1,NCKAP1,CHN2,WASF2,ACTR2,ACTR3,BAIAP2,ARF4,MAP3K2 |
| Regulation of RAC1 activity | PREX2,DEF6,CHN2,RALBP1,ARHGEF25,CHN1,ARHGAP1,RAP1GDS1,ABR,ARHGAP9 |
| CDC42 signaling events | ACTR3,CTNNA1,ARPC4,ACTR2,BAIAP2,IQGAP3,CDC42BPA,CFL1,TNK2,ARPC5 |
Protein Function
EPS8 has several biochemical functions, for example, Rac GTPase binding,SH3/SH2 adaptor activity,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPS8 itself. We selected most functions EPS8 had, and list some proteins which have the same functions with EPS8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | ALDOA,IPP,FMN2,MTSS1LA,ADD1,RP2,WASF3,GMFB,FSCN2A,INF2 |
| SH3/SH2 adaptor activity | GRAP,PAG1,ITSN2,SH2D3A,LASP1,NCK1,ARHGAP1,CHN2,SLA2,GRB2 |
| Rac GTPase binding | RALBP1,MAP3K11,FMNL1,SRGAP3,PAK2B,PAK7,ARHGEF2,SRGAP2A,FLNA,NOX1 |
| protein binding | DCP2,CD1A,GMIP,LRCH3,OXR1,WBP2,TMEM190,COMMD1,PKN2,TMEM119 |
Interacting Protein
EPS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPS8.
BAIAP2;HNRNPC;GRB2;RUNX1T1;GOLGA8DP
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References
- Xiao, X; Mruk, DD; et al. Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins. HUMAN REPRODUCTION 29:1279-1291(2014).
- Cheng, CY; Mruk, DD; et al. The Blood-Testis Barrier and Its Implications for Male Contraception. PHARMACOLOGICAL REVIEWS 64:16-64(2012).
