| Description : |
This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
168.3 kDa |
| AA Sequence : |
MPNEGIPHSSQTQEQDCLQSQPVSN NEEMAIKQESGGDGEVEEYLSFRSV GDGLSTSAVGCASAAPRRGPALLHI DRHQIQAVEPSAQALELQGLGVDVY DQDVLEQGVLQQVDNAIHEASRASQ LVDVEKEYRSVLDDLTSCTTSLRQI NKIIEQLSPQAATSRDINRKLDSVK RQKYNKEQQLKKITAKQKHLQAILG GAEVKIELDHASLEEDAEPGPSSLG SMLMPVQETAWEELIRTGQMTPFGT QIPQKQEKKPRKIMLNEASGFEKYL ADQAKLSFERKKQGCNKRAARKAPA PVTPPAPVQNKNKPNKKARVLSKKE ERLKKHIKKLQKRALQFQGKVGLPK ARRPWESDMRPEAEGDSEGEESEYF PTEEEEEEEDDEVEGAEADLSGDGT DYELKPLPKGGKRQKKVPVQEIDDD FFPSSGEEAEAASVGEGGGGGRKVG RYRDDGDEDYYKQRLRRWNKLRLQD KEKRLKLEDDSEESDAEFDEGFKVP GFLFKKLFKYQQTGVRWLWELHCQQ AGGILGDEMGLGKTIQIIAFLAGLS YSKIRTRGSNYRFEGLGPTVIVCPT TVMHQWVKEFHTWWPPFRVAILHET GSYTHKKEKLIRDVAHCHGILITSY SYIRLMQDDISRYDWHYVILDEGHK IRNPNAAVTLACKQFCTPHRIILSG SPMQNNLRELWSLFDFIFPGKLGTL PVFMEQFSVPITMGGYSNASPVQVK TAYKCACVLRDTINPYLLRRMKSDV KMSLSLPDKNEQVLFCRLTDEQHKV YQNFVDSKEVYRILNGEMQIFSGLI ALRKICNHPDLFSGGPKNLKGLPDD ELEEDQFGYWKRSGKMIVVESLLKI WHKQGQRVLLFSQSRQMLDILEVFL RAQKYTYLKMDGTTTIASRQPLITR YNEDTSIFVFLLTTRVGGLGVNLTG ANRVVIYDPDWNPSTDTQARERAWR IGQKKQVTVYRLLTAGTIEEKIYHR QIFKQFLTNRVLKDPKQRRFFKSND LYELFTLTSPDASQSTETSAIFAGT GSDVQTPKCHLKRRIPPAFGADHDV PKRKKFPASNISVNDATSSEEKSEA KGAEVNAVTSNRSDPLKDDPHMSSN VTSNDRLGEETNAVSGPEELSVISG NGECSNSSGTGKTSMPSGDESIDEK LGLSYKRERPSQAQTEAFWENKQME NNFYKHKSKTKHHSVAEEETLEKHL RPKQKPKNSKHCRDAKFEGTRIPHL VKKRRYQKQDSENKSEAKEQSNDDY VLEKLFKKSVGVHSVMKHDAIMDGA SPDYVLVEAEANRVAQDAPKALRLS RQRCLGAVSGVPTWTGHRGISGAPA GKKSRFGKKRNSNFSVQHPSSTSPT EKCQDGIMKKEGKDNVPEHFSGRAE DADSSSGPLASSSLLAKMRARNHLI LPERLESESGHLQEASALLPTTEHD DLLVEMRNFIAFQAHTDGQASTREI LQEFESKLSASQSCVFRELLRNLCT FHRTSGGEGIWKLKPEYCTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
