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FANCC

  • Official Full Name

    Fanconi anemia, complementation group C

  • Overview

    The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C.
  • Synonyms

    FANCC; Fanconi anemia, complementation group C; FACC; Fanconi anemia group C protein; FA3; FAC; FLJ14675;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FANCC-12737H Recombinant Human FANCC, GST-tagged E.coli GST 206-558a.a.
Human FANCC-3828H Recombinant Human FANCC Protein, GST-tagged Wheat Germ GST
Human FANCC-6333HCL Recombinant Human FANCC 293 Cell Lysate HEK293 N/A
Human FANCC-497H Recombinant Human FANCC Protein (1-558 aa), His-SUMO-tagged E.coli His/SUMO 1-558 aa
Human FANCC-4664HF Recombinant Full Length Human FANCC Protein, GST-tagged In Vitro Cell Free System GST 558 amino acids
Zebrafish FANCC-3813Z Recombinant Zebrafish FANCC Mammalian Cell His
Chicken FANCC-1724C Recombinant Chicken FANCC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FANCC Related Articles

FANCC involved in several pathways and played different roles in them. We selected most pathways FANCC participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fanconi anemia pathwayRPA1;USP1;STRA13;POLK;FANCG;FUZ;APITD1;BRCA2;MLH1

FANCC has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCC itself. We selected most functions FANCC had, and list some proteins which have the same functions with FANCC. You can find most of the proteins on our site.

Function Related Protein
protein bindingIST1;TRIM5;CCDC151;CSF1;EIF2AK2;HNRPLL;TNIP3;WRN;HSPB2

FANCC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCC here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCC.

FANCE; SPTAN1; HSP90B1; FANCA; CDK1; HSP90AB1; q96be0_human; FANCG; BUB1; EGFR; NRAS

Mi, J; Qiao, F; et al. FANCG is phosphorylated at serines 383 and 387 during mitosis. MOLECULAR AND CELLULAR BIOLOGY 24:8576-8585(2004).
Donahue, SL; Lundberg, R; et al. Deficient regulation of DNA double-strand break repair in Fanconi anemia fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY 278:29487-29495(2003).
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