FANCL
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Official Full Name
Fanconi anemia, complementation group L
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Overview
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. -
Synonyms
FANCL; Fanconi anemia, complementation group L; PHD finger protein 9 , PHF9; E3 ubiquitin-protein ligase FANCL; FAAP43; FLJ10335; Pog; FANCL_HUMAN; Fanconi anemia complementation group L; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; PHD finger protein 9; PHF9; Ubiquitin ligase protein FANCL;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | FANCL-191H | Recombinant Human FANCL, GST-tagged | Sf9 Insect Cell | GST | ||
Human | FANCL-12741H | Recombinant Human FANCL, His-tagged | E.coli | His | 1-375a.a. | |
Human | FANCL-3834H | Recombinant Human FANCL Protein, GST-tagged | Wheat Germ | GST | ||
Human | FANCL-6330HCL | Recombinant Human FANCL 293 Cell Lysate | HEK293 | N/A | ||
Human | FANCL-4668HF | Recombinant Full Length Human FANCL Protein, GST-tagged | In Vitro Cell Free System | GST | 375 amino acids | |
Mouse | FANCL-5674M | Recombinant Mouse FANCL Protein | Mammalian Cell | His | ||
Mouse | FANCL-3112M | Recombinant Mouse FANCL Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | FANCL-3112M-B | Recombinant Mouse FANCL Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | FANCL-12228Z | Recombinant Zebrafish FANCL | Mammalian Cell | His | ||
Chicken | FANCL-3270C | Recombinant Chicken FANCL | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- FANCL Related Articles
FANCL involved in several pathways and played different roles in them. We selected most pathways FANCL participated on our site, such as Fanconi anemia pathway, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fanconi anemia pathway | EME2;CDK5R2;RMI1;ERCC4;HER9;TOP3B;ZBTB32;STRA13;MUS81 |
Ubiquitin mediated proteolysis | SYVN1;UBE2G2;PML;WWP2;UBA3;FBXO2;NEDD4;UBE4B;UBE2E1 |
FANCL has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCL itself. We selected most functions FANCL had, and list some proteins which have the same functions with FANCL. You can find most of the proteins on our site.
Function | Related Protein |
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ligase activity | CMTM2A;RNF125;TRIM39;ACSL1;MGRN1;MARCH6;MARCH9;RNF185;PPIL2 |
protein binding | THG1L;CACFD1;C1QB;CLN6;CCNE1;FSTL1;SOX2;MLL1;PAIP1 |
ubiquitin protein ligase activity | FBXO30;UBE2G2;UBE2G1B;TRIM32;TRIM71;TRIM63;MSL2A;CBL;HECW1B |
ubiquitin protein ligase binding | UBE2NB;GPR19;ARRB1;CDKN1A;TRAF5;FAF1;BRCA1;AXIN2;UBE2Z |
ubiquitin-protein transferase activity | TRIM36;PDZRN3;FBXL7;RNF139;TRAF4;G2E3;RFWD3;RNF125;RNF213 |
zinc ion binding | ISL2A;BRPF3;HLTF;LNX2;ADAM10B;SF1;ZDHHC21;TET1;NR4A1 |
FANCL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCL here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCL.
GRN; TFCP2; RBM45; CCDC36; DOCK8; LZTS2; KIFC3
- Q&As
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