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FANCL

  • Official Full Name

    Fanconi anemia, complementation group L

  • Overview

    The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms.
  • Synonyms

    FANCL; Fanconi anemia, complementation group L; PHD finger protein 9 , PHF9; E3 ubiquitin-protein ligase FANCL; FAAP43; FLJ10335; Pog; FANCL_HUMAN; Fanconi anemia complementation group L; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; PHD finger protein 9; PHF9; Ubiquitin ligase protein FANCL;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FANCL-191H Recombinant Human FANCL, GST-tagged Sf9 Insect Cell GST
Human FANCL-12741H Recombinant Human FANCL, His-tagged E.coli His 1-375a.a.
Human FANCL-3834H Recombinant Human FANCL Protein, GST-tagged Wheat Germ GST
Human FANCL-6330HCL Recombinant Human FANCL 293 Cell Lysate HEK293 N/A
Human FANCL-4668HF Recombinant Full Length Human FANCL Protein, GST-tagged In Vitro Cell Free System GST 375 amino acids
Mouse FANCL-5674M Recombinant Mouse FANCL Protein Mammalian Cell His
Mouse FANCL-3112M Recombinant Mouse FANCL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FANCL-3112M-B Recombinant Mouse FANCL Protein Pre-coupled Magnetic Beads HEK293
Zebrafish FANCL-12228Z Recombinant Zebrafish FANCL Mammalian Cell His
Chicken FANCL-3270C Recombinant Chicken FANCL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FANCL Related Articles

FANCL involved in several pathways and played different roles in them. We selected most pathways FANCL participated on our site, such as Fanconi anemia pathway, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fanconi anemia pathwayEME2;CDK5R2;RMI1;ERCC4;HER9;TOP3B;ZBTB32;STRA13;MUS81
Ubiquitin mediated proteolysisSYVN1;UBE2G2;PML;WWP2;UBA3;FBXO2;NEDD4;UBE4B;UBE2E1

FANCL has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCL itself. We selected most functions FANCL had, and list some proteins which have the same functions with FANCL. You can find most of the proteins on our site.

Function Related Protein
ligase activityCMTM2A;RNF125;TRIM39;ACSL1;MGRN1;MARCH6;MARCH9;RNF185;PPIL2
protein bindingTHG1L;CACFD1;C1QB;CLN6;CCNE1;FSTL1;SOX2;MLL1;PAIP1
ubiquitin protein ligase activityFBXO30;UBE2G2;UBE2G1B;TRIM32;TRIM71;TRIM63;MSL2A;CBL;HECW1B
ubiquitin protein ligase bindingUBE2NB;GPR19;ARRB1;CDKN1A;TRAF5;FAF1;BRCA1;AXIN2;UBE2Z
ubiquitin-protein transferase activityTRIM36;PDZRN3;FBXL7;RNF139;TRAF4;G2E3;RFWD3;RNF125;RNF213
zinc ion bindingISL2A;BRPF3;HLTF;LNX2;ADAM10B;SF1;ZDHHC21;TET1;NR4A1

FANCL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCL here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCL.

GRN; TFCP2; RBM45; CCDC36; DOCK8; LZTS2; KIFC3

Anney, RJL; Avbersek, A; et al. Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies. LANCET NEUROLOGY 13:893-903(2014).
Huang, YL; Leung, JWC; et al. Modularized Functions of the Fanconi Anemia Core Complex. CELL REPORTS 7:1849-1857(2014).
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