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FANCM

Official Full Name

Fanconi anemia, complementation group M
Overview

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. [provided by RefSeq, Jul 2008]
Synonyms

FANCM; Fanconi anemia, complementation group M; FAAP250; KIAA1596; Fanconi anemia group M protein; protein Hef ortholog; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FANCM-3835H	Recombinant Human FANCM Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FANCM-595HCL	Recombinant Human FANCM cell lysate		N/A		Inquiry
Human	FANCM-4669HF	Recombinant Full Length Human FANCM Protein, GST-tagged	In Vitro Cell Free System	GST	669 amino acids	Inquiry
Mouse	FANCM-5675M	Recombinant Mouse FANCM Protein	Mammalian Cell	His		Inquiry
Mouse	FANCM-3113M	Recombinant Mouse FANCM Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	FANCM-3113M-B	Recombinant Mouse FANCM Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	FANCM-6367Z	Recombinant Zebrafish FANCM	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FANCM Related Articles

FANCM involved in several pathways and played different roles in them. We selected most pathways FANCM participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Fanconi anemia pathway	FANCA;RAD51;EME1;APITD1;RPA2;UBE2T;PALB2;RMI1;RPA1

FANCM has several biochemical functions, for example, ATP binding, DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCM itself. We selected most functions FANCM had, and list some proteins which have the same functions with FANCM. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	KIF4;ATP2B1;PSMC4;ATPBD4;PCXB;CAMK1D;UBA5;MAPK3;CARKD
DNA binding	TAF9;ZNF469;ZBTB20;MYEF2;PEG10;ZFP426;HIST3H3;NHEJ1;UBN2A
chromatin binding	TBL1Y;FABP1;SP140;HMGA1;YAP1;ZGLP1;POU2F1;NCAPD3;SKI
helicase activity	EIF4A1;DDX39AA;DDX39;ACTG2;MCM9;DHX57;DDX51;DHX34;SETX
nuclease activity	ANG3;ENDOG;SND1;EXOG;MEIOB;RAD9;RNASEL3;RNASEKA;EAR4
protein binding	BTN2A2;NXT1;MATN4;SETDB1;MRFAP1L1;BRD4;OGT;CETN3;SF3B3

FANCM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCM here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCM.

TRIM27; APITD1; Cep85l; FANCA; MYC; Ppp2ca; FAAP100; CUL4B; Sass6; Ufl1; FANCB; TNRC6A; SORT1; KIFC3; PCIF1; CDKN2AIP

Stoepker, C; Faramarz, A; et al. DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity. DNA REPAIR 26:54-64(2015).

Lorenz, A; Mehats, A; et al. Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombination. NUCLEIC ACIDS RESEARCH 42:13723-13735(2014).