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FBXO4

  • Official Full Name

    F-box protein 4

  • Overview

    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
  • Synonyms

    FBXO4; F-box protein 4; F box only protein 4; F-box only protein 4; FBX4; DKFZp547N213; F box protein 4; F box protein Fbx4; FBXO 4; FLJ10141; F-box protein Fbx4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FBXO4-3945H Recombinant Human FBXO4 Protein, GST-tagged Wheat Germ GST
Human FBXO4-6295HCL Recombinant Human FBXO4 293 Cell Lysate HEK293 N/A
Human FBXO4-1791H Recombinant Human FBXO4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FBXO4-4676HF Recombinant Full Length Human FBXO4 Protein, GST-tagged In Vitro Cell Free System GST 387 amino acids
Human FBXO4-5968H Recombinant Human FBXO4 protein, His-tagged E.coli His 1-387aa
Mouse FBXO4-5750M Recombinant Mouse FBXO4 Protein Mammalian Cell His
Mouse FBXO4-3166M-B Recombinant Mouse FBXO4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Fbxo4-290M Recombinant Mouse Fbxo4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse FBXO4-3166M Recombinant Mouse FBXO4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FBXO4 Related Articles

FBXO4 involved in several pathways and played different roles in them. We selected most pathways FBXO4 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisMGRN1B;PRPF19;SOCS1;UBE2H;UBE2IA;UBE2E3;ANAPC4;FZR1A;UBE2S

FBXO4 has several biochemical functions, for example, protein binding, protein homodimerization activity, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO4 itself. We selected most functions FBXO4 had, and list some proteins which have the same functions with FBXO4. You can find most of the proteins on our site.

Function Related Protein
protein bindingFHL1;FNBP1;VEGFB;GNPDA2;H3F3A;MGP;THEG;NDUFS1;P4HA2
protein homodimerization activityBARD1;GRPEL2;ASCL1;NTRK1;USH2A;AOC3;CSF1R;FGFR1OP2;APOBEC3G
ubiquitin-protein transferase activityRNF182;CBL;BIRC3;DZIP3;FBXL21;ITCH;ARIH2;LNX2B;TRIM68

FBXO4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO4.

CUL1; YWHAE; SKP1; Ywhae; SKP1; 22046569; HSP90AB1; Ywhae; NEDD8

Lee, EK; Lian, Z; et al. The FBXO4 Tumor Suppressor Functions as a Barrier to Braf(V600E)-Dependent Metastatic Melanoma. MOLECULAR AND CELLULAR BIOLOGY 33:4422-4433(2013).
Zhou, F; Yan, H; et al. FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 438:427-432(2013).
  • Q&As
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