|Official Full Name||F-box protein 8|
|Background||This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.|
|Synonyms||FBXO8; F-box protein 8; F box only protein 8; F-box only protein 8; FBS; FBX8; F-box protein Fbx8; F-box/SEC7 protein FBS; DC10|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
fbxo8 involved in several pathways and played different roles in them. We selected most pathways fbxo8 participated on our site, such as Arf6 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with fbxo8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Arf6 signaling events||ARAP2; EGF; ADAP1; AGTR1; ADRB2; KIF13B; EGFR; EPHA2; IPCEF1; EFNA1|
fbxo8 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by fbxo8 itself. We selected most functions fbxo8 had, and list some proteins which have the same functions with fbxo8. You can find most of the proteins on our site.
|ARF guanyl-nucleotide exchange factor activity||PSD3; PSD4; CYTH3; CYTH4; CYTH1A; PSD2; IQSEC1; MON2; CYTH1; FBXO8|
fbxo8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fbxo8 here. Most of them are supplied by our site. Hope this information will be useful for your research of fbxo8.