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FBXO8

  • Official Full Name

    F-box protein 8

  • Overview

    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.
  • Synonyms

    FBXO8; F-box protein 8; F box only protein 8; F-box only protein 8; FBS; FBX8; F-box protein Fbx8; F-box/SEC7 protein FBS; DC10;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FBXO8-3962H Recombinant Human FBXO8 Protein, GST-tagged Wheat Germ GST
Human FBXO8-6288HCL Recombinant Human FBXO8 293 Cell Lysate HEK293 N/A
Human FBXO8-4683HF Recombinant Full Length Human FBXO8 Protein, GST-tagged In Vitro Cell Free System GST 319 amino acids
Mouse FBXO8-5762M Recombinant Mouse FBXO8 Protein Mammalian Cell His
Mouse FBXO8-3176M Recombinant Mouse FBXO8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FBXO8-3176M-B Recombinant Mouse FBXO8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FBXO8-1668R Recombinant Rhesus monkey FBXO8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FBXO8-1492R-B Recombinant Rhesus Macaque FBXO8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FBXO8-1492R Recombinant Rhesus Macaque FBXO8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish FBXO8-3746Z Recombinant Zebrafish FBXO8 Mammalian Cell His
Chicken FBXO8-1586C Recombinant Chicken FBXO8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

FBXO8 involved in several pathways and played different roles in them. We selected most pathways FBXO8 participated on our site, such as Arf6 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arf6 signaling eventsUSP6;KIF13B;EPHA2;EGF;ADAP1;GULP1;EFNA1;EGFR;ADRB2

FBXO8 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO8 itself. We selected most functions FBXO8 had, and list some proteins which have the same functions with FBXO8. You can find most of the proteins on our site.

Function Related Protein
ARF guanyl-nucleotide exchange factor activityFBXO8;CYTH4B;IQSEC1;PSD3;ARFGEF2;PSD2;MON2;CYTH3;CYTH1A

FBXO8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO8 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO8.

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