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FER

Official Full Name

fer (fps/fes related) tyrosine kinase
Overview

FER tyrosine kinase is involved in cadherin, PECAM-1, and integrin mediated cytoskeletal connections. More recent research has also linked FER to decreasing the innate immune response. FER has also been implicated in the control of lipopolysaccharide induced epithelial dysfunction. FER has been shown to be essential in microtubule characteristics in the oocyte meiotic spindle and could also play a role in germinal vesicle breakdown.
Synonyms

FER; fer (fps/fes related) tyrosine kinase; tyrosine-protein kinase Fer; phosphoprotein NCP94; PPP1R74; protein phosphatase 1; regulatory subunit 74; TYK3; p94-Fer; tyrosine kinase 3; proto-oncogene c-Fer; feline encephalitis virus-related kinase FER; protein phosphatase 1, regulatory subunit 74; fujinami poultry sarcoma/Feline sarcoma-related protein Fer; FerT;

Type

Recombinant Proteins

Species

Bacillus subtilis
Human
Human

Source

E. coli or Yeast
E.coli
Insect (sf21)
Insect Cell
Sf21
Sf9 Insect Cell

Tag

GST
GST|His
His
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FER-79H	Active Recombinant Human FER(541-end) Protein, N-His-tagged	Sf21	His	541-end	Inquiry
Human	FER-2611H	Recombinant Human FER, GST-tagged	Insect Cell	GST		Inquiry
Human	FER-12842H	Recombinant Human FER, His-tagged	E.coli	His	96-445a.a.	$319 / 25ug
Human	FER-2706H	Recombinant Human FER, GST-His	Sf9 Insect Cell	GST		Inquiry
Human	FER-4073H	Active Recombinant Human FER Protein, GST/His-tagged	Insect Cell	GST/His		Inquiry
Human	FER-9911HF	Active Recombinant Full Length Human FER Protein, GST-tagged	Insect (sf21)	GST	1-822(end)	Inquiry
Human	FER-1323S	Recombinant Human FER Protein (M1-T822), Tag Free	Insect Cell	No tag	M1-T822	Inquiry
Human	FER-1869H	Recombinant Human FER protein, GST-tagged	E.coli	GST	96-445 aa	$319 / 25ug
Human	FER-1324S	Recombinant Human FER Protein (M1-T822), GST tagged	Insect Cell	GST	M1-T822	Inquiry
Bacillus subtilis	FER-2084B	Recombinant Bacillus subtilis FER protein, His-tagged	E. coli or Yeast	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FER Related Articles

FER involved in several pathways and played different roles in them. We selected most pathways FER participated on our site, such as Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FER were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adherens junction	ACTN2;ACTB2;CDC42L2;LEF1;SMAD2;LMO7;TGFBR1;TGFBR1A;RAC3

FER has several biochemical functions, for example, ATP binding, Rab GTPase binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FER itself. We selected most functions FER had, and list some proteins which have the same functions with FER. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	MYH15;PMS1;ASS1;ACVR1B;KITA;RIPK2;MAP3K13;ROCK2B;CLK4
Rab GTPase binding	ODF2;CCDC64B;LLGL2;AP3M1;RABGEF1;TBC1D30;SYTL2;SYTL4;UNC13D
actin binding	EPS8L2;WASH1;MYO6;MYO7A;MYHC4;CNN1;FGD4;MTAP1A;SPATA31
cadherin binding	FXYD5;PSEN1;TBC1D2;CD46;FER;P2RX4;PROM1;CD2AP;CTNNA3
epidermal growth factor receptor binding	SNX2;HBEGFA;FAM83B;EPGN;AREG;BTC;HBEGF;SOCS5;SNX1
gamma-catenin binding	CDH2;PTBP3;DSG1A;APC2;DSG1;PTPRJ;PTPRK;CTNNA1;CDH1
lipid binding	PLUNC;ATP5G1;S1PR2;FNBP1;FABP10A;DLC1;VCP;O3far1;FAM125A
non-membrane spanning protein tyrosine kinase activity	PTK6;FRK;FYNA;FYNB;PTK2AA;MATK;SRMS;RIPK2;LYN
protein binding	RAB3B;POLA1;ACSS1;SH2D1B;EXO1;NDFIP2;C7orf49;MRPS12;SUV39H2
protein kinase binding	TPX2;PTPRJ;IL12RB2;NME2;KCNH1;PTPRK;RACGAP1;SPAG16;RB1CC1
protein phosphatase 1 binding	PHACTR3;FER;SH3RF2;PHACTR3B;PPP1R15A;PPP1R11;TCTEX1D4;STAU1;SHOC2
protein tyrosine kinase activity	JAK1;PTK7A;LTK;FGR;KITA;RET;TNK1;NTRK3A;IGF1R

FER has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FER here. Most of them are supplied by our site. Hope this information will be useful for your research of FER.

bosutinib; CDC37; KCTD4; saicar; PTPN1; chBcat; ERBB2; PKM; ERBB3; NSF; Ctnnb1; ABI1; HSP90AB1; PIK3R1; CRK; PPP1R7

Wanderley, CWS; Silva, CMS; et al. Bothrops jararacussu snake venom-induces a local inflammatory response in a prostanoid- and neutrophil-dependent manner. TOXICON 90:134-147(2014).

Redpath, GMI; Woolger, N; et al. Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair. MOLECULAR BIOLOGY OF THE CELL 25:3037-3048(2014).