FERMT2

Official Full Name

fermitin family member 2
Overview

Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites.
Synonyms

FERMT2; fermitin family member 2; MIG2; KIND2; mig-2; UNC112; PLEKHC1; UNC112B; fermitin family homolog 2; kindlin 2; kindlin-2; mitogen inducible gene 2 protein; mitogen-inducible gene 2 protein; PH domain-containing family C member 1; pleckstrin homology domain-containing family C member 1; pleckstrin homology domain containing, family C member 1; pleckstrin homology domain containing, family C (with FERM domain) member 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FERMT2-12845H	Recombinant Human FERMT2, GST-tagged	E.coli	GST	C-term-350a.a.	$319 / 25μg
Human	FERMT2-6262HCL	Recombinant Human FERMT2 293 Cell Lysate	HEK293	Non		Inquiry
Human	FERMT2-6743H	Recombinant Human FERMT2 protein, His-tagged	E.coli	His	1-680a.a.	Inquiry
Human	FERMT2-4554H	Recombinant Human FERMT2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Mouse	Fermt2-2988M	Recombinant Mouse Fermt2 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Rhesus Macaque	FERMT2-1689R	Recombinant Rhesus monkey FERMT2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	FERMT2-1511R-B	Recombinant Rhesus Macaque FERMT2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	FERMT2-1511R	Recombinant Rhesus Macaque FERMT2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Zebrafish	FERMT2-8131Z	Recombinant Zebrafish FERMT2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

FERMT2 involved in several pathways and played different roles in them. We selected most pathways FERMT2 participated on our site, such as Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with FERMT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell junction organization	CLDN7;PVRL2L;PLECA;CDH10;CLDN23;CDH10A;CLDN4;ANG;ITGB1B.1
Cell-Cell communication	DCC;CDH8;KIRREL;F11R.2;PVRL2L;CADM2B;CDH3;DSCAMA;CDH18
Cell-extracellular matrix interactions	PARVB;TESK1;FBLIM1;ITGB1B.1;FERMT2;RSU1;LIMS1

FERMT2 has several biochemical functions, for example, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FERMT2 itself. We selected most functions FERMT2 had, and list some proteins which have the same functions with FERMT2. You can find most of the proteins on our site.

Function	Related Protein
phosphatidylinositol-3,4,5-trisphosphate binding	PHLDA3;GBF1;ARAP1;BTK;ZFYVE16;FAM21C;RS1;ARAP3;OGT
protein binding	CYTH3;RBP7;NFS1;AKAP9;RDH12;Serpina1b;VHLL;CCNB2;C2orf63

FERMT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FERMT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FERMT2.

CTNNB1; TCF4; ITGB5

Research Area

Focal Adhesion Adaptor and Scaffold Proteins

Adaptor Proteins

Tan, CL; Andrews, MR; et al. Kindlin-1 Enhances Axon Growth on Inhibitory Chondroitin Sulfate Proteoglycans and Promotes Sensory Axon Regeneration. JOURNAL OF NEUROSCIENCE 32:7325-7335(2012).

Sin, S; Bonin, F; et al. Role of the Focal Adhesion Protein Kindlin-1 in Breast Cancer Growth and Lung Metastasis. JOURNAL OF THE NATIONAL CANCER INSTITUTE 103:1323-1337(2011).