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FPGT

  • Official Full Name

    fucose-1-phosphate guanylyltransferase

  • Overview

    L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene.
  • Synonyms

    FPGT; fucose-1-phosphate guanylyltransferase; GFPP; Fucose 1 phosphate guanyltransferase; Fucose 1 phosphate guanylyltransferase; GDP beta L fucose pyrophosphorylase; GDP L fucose diphosphorylase; GDP L fucose pyrophosphorylase; GDP-L-fucose diphosphorylase; GDP-beta-L-fucose pyrophosphorylase; fucose-1-phosphate guanyltransferase;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FPGT-6139HCL Recombinant Human FPGT 293 Cell Lysate HEK293 N/A
Human FPGT-1396H Recombinant Human FPGT Protein (1-594 aa), His-tagged Yeast His 1-594 aa
Human FPGT-740H Recombinant Human FPGT Protein, His-tagged E.coli His Leu127~Ser377
Human FPGT-4484H Recombinant Human FPGT Protein, GST-tagged Wheat Germ GST
Human FPGT-5129HF Recombinant Full Length Human FPGT Protein, GST-tagged In Vitro Cell Free System GST 594 amino acids
Mouse Fpgt-741M Recombinant Mouse Fpgt Protein, His-tagged E.coli His His314~Leu513
Rhesus Macaque FPGT-1749R Recombinant Rhesus monkey FPGT Protein, His-tagged Mammalian Cell His
Rhesus Macaque FPGT-1571R Recombinant Rhesus Macaque FPGT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FPGT-1571R-B Recombinant Rhesus Macaque FPGT Protein Pre-coupled Magnetic Beads HEK293
Zebrafish FPGT-2894Z Recombinant Zebrafish FPGT Mammalian Cell His
Chicken FPGT-4501C Recombinant Chicken FPGT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FPGT Related Articles

FPGT involved in several pathways and played different roles in them. We selected most pathways FPGT participated on our site, such as Fructose and mannose metabolism, Amino sugar and nucleotide sugar metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FPGT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fructose and mannose metabolismPFKMA;ALDOC;TPI1B;PFKFB2;GMDS;TPI1A;AKR1B10;FBP1A;FPGT
Amino sugar and nucleotide sugar metabolismPGM2;NPL;GPIA;CYB5R1;UGDH;NANSA;CHIT1;NANP;HKDC1
Metabolic pathwaysPNPLA3;SHMT2;ATP6AP1;ST6GALNAC6;DPYD;CYP2C54;CYP4A14;B4GALT6;DMGDH

FPGT has several biochemical functions, for example, GTP binding, catalytic activity, fucose-1-phosphate guanylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FPGT itself. We selected most functions FPGT had, and list some proteins which have the same functions with FPGT. You can find most of the proteins on our site.

Function Related Protein
GTP bindingSEPT8B;RRAGB;GNAZ;DRG1;RAP1B;RALAA;LRRK1;RAB33A;SRPRB
catalytic activityNANSB;PPM1BB;AGXTB;PHKA1;PHKB;APOBEC2A;MOXD1L;CDYL;ZRANB3
fucose-1-phosphate guanylyltransferase activity

FPGT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FPGT here. Most of them are supplied by our site. Hope this information will be useful for your research of FPGT.

Bochicchio, MA; Vaira, L; et al. FPGT: An Online System for Customized Fetal and Pediatric Growth Tracking. 2014 IEEE-EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL AND HEALTH INFORMATICS (BHI) :424-427(2014).
Trifonov, VA; Dementyeva, PV; et al. Transcription of a protein-coding gene on B chromosomes of the Siberian roe deer (Capreolus pygargus). BMC BIOLOGY 11:-(2013).
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