Recombinant Human FPGT Protein, GST-tagged

• Cat.No.: FPGT-4484H
• Product Overview: Human FPGT full-length ORF ( NP_003829.2, 1 a.a. - 594 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 93 kDa
• AA Sequence: MAAARDPPEVSLREATQRKLRRFSE LRGKLVARGEFWDIVAITAADEKQE LAYNQQLSEKLKRKELPLGVQYHVF VDPAGAKIGNGGSTLCALQCLEKLY GDKWNSFTILLIHSGGYSQRLPNAS ALGKIFTALPLGNPIYQMLELKLAM YIDFPLNMNPGILVTCADDIELYSI GEFEFIRFDKPGFTALAHPSSLTIG TTHGVFVLDPFDDLKHRDLEYRSCH RFLHKPSIEKMYQFNAVCRPGNFCQ QDFAGGDIADLKLDSDYVYTDSLFY MDHKSAKMLLAFYEKIGTLSCEIDA YGDFLQALGPGATVEYTRNTSNVIK EESELVEMRQRIFHLLKGTSLNVVV LNNSKFYHIGTTEEYLFYFTSDNSL KSELGLQSITFSIFPDIPECSGKTS CIIQSILDSRCSVAPGSVVEYSRLG PDVSVGENCIISGSYILTKAALPAH SFVCSLSLKMNRCLKYATMAFGVQD NLKKSVKTLSDIKLLQFFGVCFLSC LDVWNLKVTEELFSGNKTCLSLWTA RIFPVCSSLSDSVITSLKMLNAVKN KSAFSLNSYKLLSIEEMLIYKDVED MITYREQIFLEISLKSSLM
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FPGT fucose-1-phosphate guanylyltransferase [ Homo sapiens ]
• Official Symbol: FPGT
• Synonyms: FPGT; fucose-1-phosphate guanylyltransferase; GFPP; GDP-L-fucose diphosphorylase; GDP-beta-L-fucose pyrophosphorylase; fucose-1-phosphate guanyltransferase
• Gene ID: 8790
• mRNA Refseq: NM_001199328
• Protein Refseq: NP_001186257
• MIM: 603609
• UniProt ID: O14772