Recombinant Human FUT3 Protein, GST-tagged

• Cat.No.: FUT3-4561H
• Product Overview: Human FUT3 full-length ORF ( NP_000140.1, 1 a.a. - 361 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 68.5 kDa
• AA Sequence: MDPLGAAKPQWPWRRCLAALLFQLL VAVCFFSYLRVSRDDATGSPRAPSG SSRQDTTPTRPTLLILLWTWPFHIP VALSRCSEMVPGTADCHITADRKVY PQADTVIVHHWDIMSNPKSRLPPSP RPQGQRWIWFNLEPPPNCQHLEALD RYFNLTMSYRSDSDIFTPYGWLEPW SGQPAHPPLNLSAKTELVAWAVSNW KPDSARVRYYQSLQAHLKVDVYGRS HKPLPKGTMMETLSRYKFYLAFENS LHPDYITEKLWRNALEAWAVPVVLG PSRSNYERFLPPDAFIHVDDFQSPK DLARYLQELDKDHARYLSYFRWRET LRPRSFSWALDFCKACWKLQQESRY QTVRSIAAWFT
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) [ Homo sapiens ]
• Official Symbol: FUT3
• Synonyms: FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); fucosyltransferase 3 (galactoside 3(4) L fucosyltransferase, Lewis blood group included), LE; galactoside 3(4)-L-fucosyltransferase; CD174; Lewis FT; fucosyltransferase III; alpha-(1,3/1,4)-fucosyltransferase; blood group Lewis alpha-4-fucosyltransferase; LE; Les; FT3B; FucT-III; MGC131739
• Gene ID: 2525
• mRNA Refseq: NM_000149
• Protein Refseq: NP_000140
• MIM: 111100
• UniProt ID: P21217