GABRE

  • Official Full Name

    gamma-aminobutyric acid (GABA) A receptor, epsilon
  • Overview

    The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein.
  • Synonyms

    GABRE;gamma-aminobutyric acid (GABA) A receptor, epsilon;gamma-aminobutyric acid receptor subunit epsilon;GABA(A) receptor;epsilon;GABA(A) receptor, epsilon;GABA(A) receptor subunit epsilon

Recombinant Proteins

  • Human
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • Yeast
  • Baculovirus
  • In Vitro Cell Free System
  • His
  • Non
  • GST
  • Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
GABRE-13101H Recombinant Human GABRE, His-tagged E.coli Human His 28-279a.a.
GABRE-6798C Recombinant Chicken GABRE Mammalian Cells Chicken His
GABRE-6059HCL Recombinant Human GABRE 293 Cell Lysate HEK293 Human Non
GABRE-1553H Recombinant Human GABRE Protein, His-tagged E.coli Human His Pro23-Lys253
GABRE-4648H Recombinant Human GABRE Protein, GST-tagged Wheat Germ Human GST
GABRE-4960H Recombinant Human GABRE protein Yeast Human Non
GABRE-4961H Recombinant Human GABRE protein E.coli Human Non
GABRE-4962H Recombinant Human GABRE protein, Avi-tagged, Biotinylated E.coli Human Avi
GABRE-4963H Recombinant Human GABRE protein Baculovirus Human Non
GABRE-5200HF Recombinant Full Length Human GABRE Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 365 amino acids

    Involved Pathway

    GABRE involved in several pathways and played different roles in them. We selected most pathways GABRE participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Nicotine addiction GRIN2B,GABRR2,GABRB1,CHRNA6,GABRR3,GABRD,GRIA2,GABRG3,GRIN2A,GRIN3B
    Neuroactive ligand-receptor interaction F2RL1,LHCGR,GRID2,AGTR2,GABRR1,Gh,PTH1R,BDKRB1,RXFP2,TRPV1
    GABAergic synapse GABBR2,GNGT2,GABRA4,GNAI2,GNG12,NSF,GABARAP,GLS2,PRKCB,GABRR1
    Retrograde endocannabinoid signaling FAAH,GRM1,MAPK3,GNG7,GNG5,GNG8,PRKCB,SLC17A8,MAPK12,MAPK13

    Protein Function

    GABRE has several biochemical functions, for example, GABA-A receptor activity,contributes_to benzodiazepine receptor activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRE itself. We selected most functions GABRE had, and list some proteins which have the same functions with GABRE. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to benzodiazepine receptor activity GABRA5,GABRG3,GABRA6A,GABRA1,GABRG1
    chloride channel activity CLCN7,CLIC3,TTYH2,GABRA5,CFTR,CLIC4,FXYD3,CLCA1,SLC26A3.1,SLC26A4
    GABA-A receptor activity GABRZ,GABRB2,GABRD,GABRA1,GABRB3,GABRR2A,GABRR2,GABRG2,GABRR3,GABRB1
    inhibitory extracellular ligand-gated ion channel activity GABRA1,GABRA3,GABRG2,GABRG3,GABRA5,GABRA6A,GABRA6,GABRA2,GABRB2,GABRG1

    Interacting Protein

    GABRE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRE here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRE.

    Resources

    Research Area

    GABA Receptors

    References

    • Knoll, S; Furst, K; et al. E2F1 induces miR-224/452 expression to drive EMT through TXNIP downregulation. EMBO REPORTS 15:1315-1329(2014).
    • Khan, MS; Zetterlund, EL; et al. Pharmacogenetics, Plasma Concentrations, Clinical Signs and EEG During Propofol Treatment. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 115:565-570(2014).

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