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Official Full Name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
Background This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5 exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist.
Synonyms GALNT4; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4); polypeptide N-acetylgalactosaminyltransferase 4; GalNAc T4; EC; GalNAc transferase 4; GalNAc-T4; GalNAcT4; GALT4_HUMAN; N-acetylgalactosaminyltransferase 4 (GalNAc-T4); Polypeptide GalNAc transferase 4; pp GaNTase 4; pp-GaNTase 4; Protein UDP acetylgalactosaminyltransferase 4; Protein-UDP acetylgalactosaminyltransferase 4; UDP GalNAc:polypeptide N-acetylgalactosaminyltransferase 4; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4; UDP-N-acetyl-alpha-D-galactosamine:polypeptide
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GALNT4-4703H Recombinant Human GALNT4 Protein, GST-tagged Wheat Germ GST
    Human GALNT4-6036HCL Recombinant Human GALNT4 293 Cell Lysate HEK293 N/A
    Mouse GALNT4-6187M Recombinant Mouse GALNT4 Protein Mammalian Cell His
    Rhesus Macaque GALNT4-1808R Recombinant Rhesus monkey GALNT4 Protein, His-tagged Mammalian Cell His

    galnt4 involved in several pathways and played different roles in them. We selected most pathways galnt4 participated on our site, such as Mucin type O-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with galnt4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mucin type O-Glycan biosynthesis GALNT18A; C1GALT1; C1GALT1B; GALNTL2; GCNT4; GALNT10; GALNT5; C1GALT1A; GCNT1; B4GALT5
    Metabolic pathways ATP5IA; HMGCL; CHSY3; LDHA; AK1; Atp5k; ZNF408; KMO; LDHB; AK2

    galnt4 has several biochemical functions, for example, carbohydrate binding, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by galnt4 itself. We selected most functions galnt4 had, and list some proteins which have the same functions with galnt4. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate binding CD209A; LY75; FBXO2; BCAN; NOMO1; GALNT10; CLEC4E; PKD1; LGALS14; HIST2H3C2
    metal ion binding CYP2K19; RNF180; PDE1B; ARHGEF1A; KCNIP3A; MGAT5B; ZBED4; TH2; ZFYVE26; COX5A
    polypeptide N-acetylgalactosaminyltransferase activity GALNT11; GALNT7; GALNT14; GALNT3; GALNT4; WBSCR17; GALNTL1; GALNT12; GALNTL2; C1GALT1C1

    galnt4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with galnt4 here. Most of them are supplied by our site. Hope this information will be useful for your research of galnt4.

    Liu, YD; Liu, WS; et al. GALNT4 Predicts Clinical Outcome in Patients with Clear Cell Renal Cell Carcinoma. JOURNAL OF UROLOGY 192:1534-1541(2014).
    Erbilgin, A; Civelek, M; et al. Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. JOURNAL OF LIPID RESEARCH 54:1894-1905(2013).

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