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Official Full Name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
Background This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.
Synonyms GALNT6; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6); polypeptide N-acetylgalactosaminyltransferase 6; GALNAC T6; GalNAc transferase 6; GalNAcT6; GALNT 6; Polypeptide GalNAc transferase 6; Polypeptide N acetylgalactosaminyltransferase 6; pp GaNTase 6; Protein UDP acetylgalactosaminyltransferase 6; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 6; UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 6 (GalNAc T6); UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 6; pp-GaNTase 6; protein-UDP acetylgalactosaminyltransferase 6; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6; UDP-N-acetyl-alpha-D-galactosamine:; GALNAC-T6
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GALNT6-22H Recombinant Human GALNT6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GALNT6-4704H Recombinant Human GALNT6 Protein, GST-tagged Wheat Germ GST
    Human GALNT6-6035HCL Recombinant Human GALNT6 293 Cell Lysate HEK293 N/A
    Mouse GALNT6-6189M Recombinant Mouse GALNT6 Protein Mammalian Cell His
    Chicken GALNT6-3219C Recombinant Chicken GALNT6 Mammalian Cell His
    Zebrafish GALNT6-12406Z Recombinant Zebrafish GALNT6 Mammalian Cell His

    galnt6 involved in several pathways and played different roles in them. We selected most pathways galnt6 participated on our site, such as Metabolic pathways, Metabolism of proteins, Mucin type O-Glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with galnt6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways NOS3; PLA2G4A; SPTLC3; DLDH; FUT1; ACO2; B4GALT1; MTHFD1; AGPAT3; PON1
    Metabolism of proteins MUC1; IGFBP6A; DDIT3; GRP; TRAPPC6A; IGFBP6B; BCS1L; CALCA; NEU4; GALNT13
    Mucin type O-Glycan biosynthesis B4GALT5; POC1B-GALNT4; ST3GAL1; C1GALT1B; ST6GALNAC1; POC1BL; C1GALT1C1; C1GALT1A; WBSCR17; B3GNT6
    O-linked glycosylation SPON1A; ADAMTSL3; ADAMTS10; ADAMTS3; B3GNT2A; KCNA6; ADAMTS15; ADAMTSL4; ADAMTS8; MUC1
    O-linked glycosylation of mucins GALNT13; B3GNT6; MUC1; MUC13; ST6GALNAC2; MUC21; MUC4; MUC5AC; GALNT5; A4GNT
    Post-translational protein modification GALNT5; PPP6C; MUCL1; ADAMTS13; NAPB; DAD1; ADAMTS20; TFG; NAPAB; ST6GALNAC1.2
    mucin core 1 and core 2 O-glycosylation GCNT3; GALNT6; GALNTL2; GALNT5; GALNT13

    galnt6 has several biochemical functions, for example, carbohydrate binding, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by galnt6 itself. We selected most functions galnt6 had, and list some proteins which have the same functions with galnt6. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate binding OLR1; CLEC6A; GFPT2; GFPT1; CLEC3B; GALNT10; CD209B; GANC; KLRA8; Cd24a
    metal ion binding ZNF410; ZNF501; CARS; TROVE2; PVALB8; CHAMP1; TRIM59; MAP3K13; GMIP; ZNF280B
    polypeptide N-acetylgalactosaminyltransferase activity C1GALT1C1; GALNTL6; GALNT1; GALNTL2; GALNT6; GALNTL1; GALNT2; GALNT5; GALNT14; GALNT3

    galnt6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with galnt6 here. Most of them are supplied by our site. Hope this information will be useful for your research of galnt6.


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