|Official Full Name||UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)|
|Background||This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.|
|Synonyms||GALNT6; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6); polypeptide N-acetylgalactosaminyltransferase 6; GALNAC T6; GalNAc transferase 6; GalNAcT6; GALNT 6; Polypeptide GalNAc transferase 6; Polypeptide N acetylgalactosaminyltransferase 6; pp GaNTase 6; Protein UDP acetylgalactosaminyltransferase 6; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 6; UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 6 (GalNAc T6); UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 6; pp-GaNTase 6; protein-UDP acetylgalactosaminyltransferase 6; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6; UDP-N-acetyl-alpha-D-galactosamine:; GALNAC-T6|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
galnt6 involved in several pathways and played different roles in them. We selected most pathways galnt6 participated on our site, such as Metabolic pathways, Metabolism of proteins, Mucin type O-Glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with galnt6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Metabolic pathways||NOS3; PLA2G4A; SPTLC3; DLDH; FUT1; ACO2; B4GALT1; MTHFD1; AGPAT3; PON1|
|Metabolism of proteins||MUC1; IGFBP6A; DDIT3; GRP; TRAPPC6A; IGFBP6B; BCS1L; CALCA; NEU4; GALNT13|
|Mucin type O-Glycan biosynthesis||B4GALT5; POC1B-GALNT4; ST3GAL1; C1GALT1B; ST6GALNAC1; POC1BL; C1GALT1C1; C1GALT1A; WBSCR17; B3GNT6|
|O-linked glycosylation||SPON1A; ADAMTSL3; ADAMTS10; ADAMTS3; B3GNT2A; KCNA6; ADAMTS15; ADAMTSL4; ADAMTS8; MUC1|
|O-linked glycosylation of mucins||GALNT13; B3GNT6; MUC1; MUC13; ST6GALNAC2; MUC21; MUC4; MUC5AC; GALNT5; A4GNT|
|Post-translational protein modification||GALNT5; PPP6C; MUCL1; ADAMTS13; NAPB; DAD1; ADAMTS20; TFG; NAPAB; ST6GALNAC1.2|
|mucin core 1 and core 2 O-glycosylation||GCNT3; GALNT6; GALNTL2; GALNT5; GALNT13|
galnt6 has several biochemical functions, for example, carbohydrate binding, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by galnt6 itself. We selected most functions galnt6 had, and list some proteins which have the same functions with galnt6. You can find most of the proteins on our site.
|carbohydrate binding||OLR1; CLEC6A; GFPT2; GFPT1; CLEC3B; GALNT10; CD209B; GANC; KLRA8; Cd24a|
|metal ion binding||ZNF410; ZNF501; CARS; TROVE2; PVALB8; CHAMP1; TRIM59; MAP3K13; GMIP; ZNF280B|
|polypeptide N-acetylgalactosaminyltransferase activity||C1GALT1C1; GALNTL6; GALNT1; GALNTL2; GALNT6; GALNTL1; GALNT2; GALNT5; GALNT14; GALNT3|
galnt6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with galnt6 here. Most of them are supplied by our site. Hope this information will be useful for your research of galnt6.
ALDOA; TMEM9; SLC5A6; AK6