Description : |
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
71.2 kDa |
AA Sequence : |
MRLLRRRHMPLRLAMVGCAFVLFLF LLHRDVSSREEATEKPWLKSLVSRK DHVLDLMLEAMNNLRDSMPKLQIRA PEAQQTLFSINQSCLPGFYTPAELK PFWERPPQDPNAPGADGKAFQKSKW TPLETQEKEEGYKKHCFNAFASDRI SLQRSLGPDTRPPECVDQKFRRCPP LATTSVIIVFHNEAWSTLLRTVYSV LHTTPAILLKEIILVDDASTEEHLK EKLEQYVKQLQVVRVVRQEERKGLI TARLLGASVAQAEVLTFLDAHCECF HGWLEPLLARIAEDKTVVVSPDIVT IDLNTFEFAKPVQRGRVHSRGNFDW SLTFGWETLPPHEKQRRKDETYPIK SPTFAGGLFSISKSYFEHIGTYDNQ MEIWGGENVEMSFRVWQCGGQLEII PCSVVGHVFRTKSPHTFPKGTSVIA RNQVRLAEVWMDSYKKIFYRRNLQA AKMAQEKSFGDISERLQLREQLHCH NFSWYLHNVYPEMFVPDLTPTFYGA IKNLGTNQCLDVGENNRGGKPLIMY SCHGLGGNQYFEYTTQRDLRHNIAK QLCLHVSKGALGLGSCHFTGKNSQV PKDEEWELAQDQLIRNSGSGTCLTS QDKKPAMAPCNPSDPHQLWLFVTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |