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GATA5

Official Full Name

GATA binding protein 5
Overview

The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.
Synonyms

GATA5; GATA binding protein 5; transcription factor GATA-5; bB379O24.1; GATA-binding factor 5; GATA5_HUMAN; GATA binding factor-5; GATA-binding protein 5;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GATA5-4751H	Recombinant Human GATA5 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GATA5-5470HF	Recombinant Full Length Human GATA5 Protein, GST-tagged	In Vitro Cell Free System	GST	397 amino acids	Inquiry
Mouse	GATA5-6226M	Recombinant Mouse GATA5 Protein	Mammalian Cell	His		Inquiry
Mouse	Gata5-1567M	Recombinant Mouse Gata5 Protein, His-tagged	E.coli	His	Met1-Leu401	Inquiry
Mouse	GATA5-3484M-B	Recombinant Mouse GATA5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	GATA5-3484M	Recombinant Mouse GATA5 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	Gata5-1568R	Recombinant Rat Gata5 Protein, His-tagged	E.coli	His	Met1-Ala397	Inquiry
Zebrafish	GATA5-8834Z	Recombinant Zebrafish GATA5	Mammalian Cell	His		Inquiry
Chicken	GATA5-6972C	Recombinant Chicken GATA5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

GATA5 involved in several pathways and played different roles in them. We selected most pathways GATA5 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Factors involved in megakaryocyte development and platelet production	HBG1;GATA5;KIF3B;KIF18A;GATA6;MFN2;KIF3A;AKAP1B;KIF2A
Hemostasis	KLC3;KCNMB2;AKAP10;EHD1;FCER1GL;ABHD12;SERPINB8;KIF4A;CD9A

GATA5 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA5 itself. We selected most functions GATA5 had, and list some proteins which have the same functions with GATA5. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZFP775;PMS2;EZH2;THAP8;THOC1;MYCL1;ZBTB16A;RORC;POLR2A
RNA polymerase II regulatory region sequence-specific DNA binding	EAF2;OSR2;ATF1;BARHL2;FOXF1;ETV5;HES6;FERD3L;ARID5B
RNA polymerase II transcription factor binding	GATA1A;GFI1B;KDM1A;GATA6;ID4;SMAD4;GSC;MTA2;GSK3B
chromatin binding	MSL1;SP3;CBX1;SMARCA2;SSBP1;SMC1AL;NR5A1;PHC1;REL
enhancer sequence-specific DNA binding	ISL1;HMGB2;FOXN4;KLF7B;LMO4;SOX9;GATA3;GATA5;GATA2
metal ion binding	ZNF143A;ZBTB20;CMAH;RNF34A;CYP2C55;SCAPER;ALKBH7;GNAS;CHSY3
protein binding	SMARCC2;TLN1;DISC1;TA;DCD;SEC22B;EPHA10;SULT4A1;ADCY6
sequence-specific DNA binding	SOX7;THRAA;TBX5;RXRGA;HOXA3;NKX6.3;FOXG1D;ZBTB33;KLF2
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	NKX2;ATF1;NR5A2;PTH;SOX9;SFPI1;PDX1;GATA6;BHLHE40
transcription factor activity, sequence-specific DNA binding	ZFP36L1;IRF3;HMGB2;HES6;FOXO1B;MLLT10;NPAS2;FOXG1A;CREB5
transcription regulatory region DNA binding	NFE2L2;MZF1;NKX3;MTERFD3;SOX5;SALL1;SMARCA2;DHX36;CDK5RAP2
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	RFX6;MAFA;RAD21;NKX2;MAFG;CSRNP3;CREB3L4;MAFBB;BARX2
zinc ion binding	RFPL2;TRIM72;PHF20B;Adam6;MLLT6;PGLYRP6;ALKBH8;EWSR1B;ZDHHC18A

GATA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA5.

Research Area

Zhang, XL; Dai, N; et al. GATA5 loss-of-function mutation in familial dilated cardiomyopathy. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 35:763-770(2015).

Wang, J; Mao, JH; et al. A Novel NKX2.6 Mutation Associated with Congenital Ventricular Septal Defect. PEDIATRIC CARDIOLOGY 36:646-656(2015).