GATA5

Official Full Name

GATA binding protein 5
Background

The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.
Synonyms

GATA5; GATA binding protein 5; transcription factor GATA-5; bB379O24.1; GATA-binding factor 5; GATA5_HUMAN; GATA binding factor-5; GATA-binding protein 5;

Type:
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species :
Chicken
Human
Mouse
Rat
Zebrafish

Source :
E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag :
GST
His
His (Fc)
Avi
N

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	GATA5-4751H	Recombinant Human GATA5 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Human	GATA5-5470HF	Recombinant Full Length Human GATA5 Protein, GST-tagged	In Vitro Cell Free System	GST	Inquiry
Mouse	GATA5-6226M	Recombinant Mouse GATA5 Protein	Mammalian Cell	His	Inquiry
Mouse	Gata5-1567M	Recombinant Mouse Gata5 Protein, His-tagged	E.coli	N-His	Inquiry
Mouse	GATA5-3484M-B	Recombinant Mouse GATA5 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	GATA5-3484M	Recombinant Mouse GATA5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	Gata5-1568R	Recombinant Rat Gata5 Protein, His-tagged	E.coli	N-His	Inquiry
Zebrafish	GATA5-8834Z	Recombinant Zebrafish GATA5	Mammalian Cell	His	Inquiry
Chicken	GATA5-6972C	Recombinant Chicken GATA5	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
GATA5 Related Articles

GATA5 involved in several pathways and played different roles in them. We selected most pathways GATA5 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Factors involved in megakaryocyte development and platelet production	AKAP10;KIF3C;AKAP1B;MAFGA;MAFG;MGC173646;KIF3B;KIF2C;D-AKAP2
Hemostasis	SLC7A10;SERPINF2B;BRPF3;CFHL1;SLC7A6;DOCK2;LOC100514666;CEACAM1;APOER2

GATA5 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA5 itself. We selected most functions GATA5 had, and list some proteins which have the same functions with GATA5. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	C17orf49;MECOM;IRF1;SNAPC1;PCGF2;ZNF593;ZNF454;PHC2;MB21D2
RNA polymerase II regulatory region sequence-specific DNA binding	PKNOX2;LYL1;HSF2;ETV5;DBP;H2AFY;ZFP39;ZNF8;GFI1AA
RNA polymerase II transcription factor binding	KLF4;MIXL1;MKX;GATA4;MEF2A;TBX20;ZGLP1;SPOP;WWP2
chromatin binding	GM606;CHD8;HMGB2B;SETD7;NCAPD2;CDC45;PHC1;BAP1;EGFR
enhancer sequence-specific DNA binding	GATA3;ISL1;TBX19;XBP1;HMGB2;SOX9;KLF6A;TFAP2B;LDB1
metal ion binding	GIT2B;PITPNM1;NSF;CYP1C2;ITGA7;NUDT1;ZNF606;FHL3B;ZBTB24
protein binding	SP100;HYAL3;TAF2;FANCG;CPNE7;CCL11;CALCOCO2;SYMPK;HIST1H2BI
sequence-specific DNA binding	MNX1;IRX5B;OTPB;SALL1A;ZNF193;RERE;ZKSCAN14;MSXB;LONP1
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	PAX3;FOXC1;MYF5;SPI1;SRF;GLI1;MEF2C;HNF1B;IRF8
transcription factor activity, sequence-specific DNA binding	ZFP770;FOXC1A;IRF1B;ETV5B;EGR3;SIX4;RCOR2;ZFP628;LEF1
transcription regulatory region DNA binding	H2AFY;IKZF2;Arid4b;NR5A2;SP1;PHB;CDK5RAP2;ZFP746;TAF7L
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	DLX2;MYOD1;GATA4;MAF;STAT3;LEF1;ATF1;CSRNP3;ALX1
zinc ion binding	FBXO40;UMPS;MMP30;BIRC3;PRICKLE1;HLTF;BTR02;ZCCHC17;PRDM2

GATA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA5.

Zhang, XL; Dai, N; et al. GATA5 loss-of-function mutation in familial dilated cardiomyopathy. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 35:763-770(2015).

Wang, J; Mao, JH; et al. A Novel NKX2.6 Mutation Associated with Congenital Ventricular Septal Defect. PEDIATRIC CARDIOLOGY 36:646-656(2015).