• Official Full Name

    GATA binding protein 5

  • Background

    The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.
  • Synonyms

    GATA5; GATA binding protein 5; transcription factor GATA-5; bB379O24.1; GATA-binding factor 5; GATA5_HUMAN; GATA binding factor-5; GATA-binding protein 5;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N
    Species Cat.# Product name Source (Host) Tag Price
    Human GATA5-4751H Recombinant Human GATA5 Protein, GST-tagged Wheat Germ GST
    Human GATA5-5470HF Recombinant Full Length Human GATA5 Protein, GST-tagged In Vitro Cell Free System GST
    Mouse GATA5-6226M Recombinant Mouse GATA5 Protein Mammalian Cell His
    Mouse Gata5-1567M Recombinant Mouse Gata5 Protein, His-tagged E.coli N-His
    Mouse GATA5-3484M-B Recombinant Mouse GATA5 Protein Pre-coupled Magnetic Beads HEK293
    Mouse GATA5-3484M Recombinant Mouse GATA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat Gata5-1568R Recombinant Rat Gata5 Protein, His-tagged E.coli N-His
    Zebrafish GATA5-8834Z Recombinant Zebrafish GATA5 Mammalian Cell His
    Chicken GATA5-6972C Recombinant Chicken GATA5 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • GATA5 Related Articles

    GATA5 involved in several pathways and played different roles in them. We selected most pathways GATA5 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Factors involved in megakaryocyte development and platelet productionAKAP10;KIF3C;AKAP1B;MAFGA;MAFG;MGC173646;KIF3B;KIF2C;D-AKAP2

    GATA5 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA5 itself. We selected most functions GATA5 had, and list some proteins which have the same functions with GATA5. You can find most of the proteins on our site.

    Function Related Protein
    DNA bindingC17orf49;MECOM;IRF1;SNAPC1;PCGF2;ZNF593;ZNF454;PHC2;MB21D2
    RNA polymerase II regulatory region sequence-specific DNA bindingPKNOX2;LYL1;HSF2;ETV5;DBP;H2AFY;ZFP39;ZNF8;GFI1AA
    RNA polymerase II transcription factor bindingKLF4;MIXL1;MKX;GATA4;MEF2A;TBX20;ZGLP1;SPOP;WWP2
    chromatin bindingGM606;CHD8;HMGB2B;SETD7;NCAPD2;CDC45;PHC1;BAP1;EGFR
    enhancer sequence-specific DNA bindingGATA3;ISL1;TBX19;XBP1;HMGB2;SOX9;KLF6A;TFAP2B;LDB1
    metal ion bindingGIT2B;PITPNM1;NSF;CYP1C2;ITGA7;NUDT1;ZNF606;FHL3B;ZBTB24
    sequence-specific DNA bindingMNX1;IRX5B;OTPB;SALL1A;ZNF193;RERE;ZKSCAN14;MSXB;LONP1
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingPAX3;FOXC1;MYF5;SPI1;SRF;GLI1;MEF2C;HNF1B;IRF8
    transcription factor activity, sequence-specific DNA bindingZFP770;FOXC1A;IRF1B;ETV5B;EGR3;SIX4;RCOR2;ZFP628;LEF1
    transcription regulatory region DNA bindingH2AFY;IKZF2;Arid4b;NR5A2;SP1;PHB;CDK5RAP2;ZFP746;TAF7L
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingDLX2;MYOD1;GATA4;MAF;STAT3;LEF1;ATF1;CSRNP3;ALX1
    zinc ion bindingFBXO40;UMPS;MMP30;BIRC3;PRICKLE1;HLTF;BTR02;ZCCHC17;PRDM2

    GATA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA5.

    Zhang, XL; Dai, N; et al. GATA5 loss-of-function mutation in familial dilated cardiomyopathy. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 35:763-770(2015).
    Wang, J; Mao, JH; et al. A Novel NKX2.6 Mutation Associated with Congenital Ventricular Septal Defect. PEDIATRIC CARDIOLOGY 36:646-656(2015).
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