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GATA5

  • Official Full Name

    GATA binding protein 5

  • Overview

    The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.
  • Synonyms

    GATA5; GATA binding protein 5; transcription factor GATA-5; bB379O24.1; GATA-binding factor 5; GATA5_HUMAN; GATA binding factor-5; GATA-binding protein 5;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GATA5-4751H Recombinant Human GATA5 Protein, GST-tagged Wheat Germ GST
Human GATA5-5470HF Recombinant Full Length Human GATA5 Protein, GST-tagged In Vitro Cell Free System GST 397 amino acids
Mouse GATA5-6226M Recombinant Mouse GATA5 Protein Mammalian Cell His
Mouse Gata5-1567M Recombinant Mouse Gata5 Protein, His-tagged E.coli N-His Met1-Leu401
Mouse GATA5-3484M-B Recombinant Mouse GATA5 Protein Pre-coupled Magnetic Beads HEK293
Mouse GATA5-3484M Recombinant Mouse GATA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Gata5-1568R Recombinant Rat Gata5 Protein, His-tagged E.coli N-His Met1-Ala397
Zebrafish GATA5-8834Z Recombinant Zebrafish GATA5 Mammalian Cell His
Chicken GATA5-6972C Recombinant Chicken GATA5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GATA5 Related Articles

GATA5 involved in several pathways and played different roles in them. We selected most pathways GATA5 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Factors involved in megakaryocyte development and platelet productionHBE1;CABLES1;HBB-BH1;MAFG;AKAP1;MAFGA;HMG20B;AKAP1B;H3F3D
HemostasisGAS6;CD9A;WDR1;MYB;GRB7;NFE2;MAFGB;SERPINF2B;HBBE3

GATA5 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA5 itself. We selected most functions GATA5 had, and list some proteins which have the same functions with GATA5. You can find most of the proteins on our site.

Function Related Protein
DNA bindingTRIM33;UNCX4.1;NR1D4A;ZNF436;PIN4;TRIM30A;BBX;MXTX2;ZFP771
RNA polymerase II regulatory region sequence-specific DNA bindingRELA;EGR1;DMRT2;MYOG;SOX13;TFAP2D;ATF4B1;BARHL1A;ATF6
RNA polymerase II transcription factor bindingTEAD3;GFI1B;NFATC1;ATF4;T;TBX20;TAL1;MTA2;ID4
chromatin bindingRAN;NUP62;HOXC13;MKRN1;RNF20;MBD1;ARID3C;POLA1;KDM5A
enhancer sequence-specific DNA bindingLDB1;ISL1;HMGB2;KLF7B;GATA1;TFAP2B;SOX11;TWIST1B;GATA5
metal ion bindingCYP2P7;CRYAA;IKZF5;RNF11B;CSRP1B;ZFP146;ZFP410;IKZF4;NR4A2B
protein bindingLINGO1;SPON1;LITAF;VIM;C9orf142;CLPX;SOCS7;KEAP1;ASCL1
sequence-specific DNA bindingHOXC10A;ATF6B;IRX5A;HSFY1;POU3F3;FOXI3B;USF1;MKX;PHOX2BB
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGLI1;MYOD1;CREB1;BHLHE40;PROX1;SOX17;PTH;NFIX;SOX10
transcription factor activity, sequence-specific DNA bindingZRANB2;HSF1;ESR1;ZKSCAN4;ZNF8;FOXC2;CLOCKB;SOX2;RXRB
transcription regulatory region DNA bindingNKX3;MZF1;YY1;SOX17;SALL3B;PROX1;ETV5;TRP53;TCF7
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingATF2;IRF2;HSF2;ATF5;GATA5;STAG2;ARID3A;PKNOX1;RFX6
zinc ion bindingZZEF1;ZNRD1;MAN2A1;MARCH6;MBD1B;USP5;ZDHHC5;MT1A;TRIM17

GATA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA5.

Zhang, XL; Dai, N; et al. GATA5 loss-of-function mutation in familial dilated cardiomyopathy. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 35:763-770(2015).
Wang, J; Mao, JH; et al. A Novel NKX2.6 Mutation Associated with Congenital Ventricular Septal Defect. PEDIATRIC CARDIOLOGY 36:646-656(2015).
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