GDF10
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Official Full Name
growth differentiation factor 10 -
Overview
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. -
Synonyms
GDF10;growth differentiation factor 10;bone morphogenetic protein 3B;BMP 3b;BIP;GDF-10;bone-inducing protein;BMP3B;BMP-3b
Recombinant Proteins
- Mouse
- Rat
- Human
- HEK293
- Mammalian Cells
- E.coli
- Human Cells
- In Vitro Cell Free System
- Fc
- His
- Non
- Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Gdf10-4014M | Recombinant Mouse Gdf10 protein, hFc-tagged | HEK293 | Mouse | Fc | Gln367-Arg476 | |
| GDF10-2501R | Recombinant Rat GDF10 Protein | Mammalian Cells | Rat | His |
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| GDF10-27683TH | Recombinant Human GDF10 protein | E.coli | Human | Non | 369-478 a.a. |
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| GDF10-2101MCL | Recombinant Mouse GDF10 cell lysate | Human Cells | Mouse | Non |
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| GDF10-2157R | Recombinant Rat GDF10 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| GDF10-2157R-B | Recombinant Rat GDF10 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GDF10-284H | Recombinant Human GDF10 Protein, His-tagged | E.coli | Human | His | Arg337~Cys477 |
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| Gdf10-286M | Recombinant Mouse Gdf10 Protein, His-tagged | E.coli | Mouse | His | Lys339~Arg477 |
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| GDF10-3319H | Recombinant Human GDF10 Protein (Gln369-Arg478), N-His tagged | E.coli | Human | His | Gln369-Arg478 |
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| GDF10-5230HF | Recombinant Full Length Human GDF10 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 288 amino acids |
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Involved Pathway
GDF10 involved in several pathways and played different roles in them. We selected most pathways GDF10 participated on our site, such as Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | GTF3AA,HMGA1-RS1,RORAA,MIXL1,CFD,EGR2B,DDIT3,AGPAT2,NRIP1,MEF2AA |
Protein Function
GDF10 has several biochemical functions, for example, cytokine activity,growth factor activity,transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF10 itself. We selected most functions GDF10 had, and list some proteins which have the same functions with GDF10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transforming growth factor beta receptor binding | TGFBRAP1,LRG1,SMURF2,GDF2,MSTN,NDR1,SPAW,LEFTY1,BMP5,MSTNA |
| cytokine activity | FAM3B,FGF2,CLCF1,Kitl,TNFRSF11B,SPAW,IL23,TNFSF10,BMP7B,CCL6 |
| growth factor activity | GDF3,IGF3,FGF14,CSF3,CSF1,PDGFD,EREG,LIF,BMP5,GDF2 |
Interacting Protein
GDF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF10.
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References
- Liu, QW; Chen, JR; et al. Identification of stage-specific markers during differentiation of hair cells from mouse inner ear stem cells or progenitor cells in vitro. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 60:99-111(2015).
- Monestier, O; Servin, B; et al. Evolutionary Origin of Bone Morphogenetic Protein 15 and Growth and Differentiation Factor 9 and Differential Selective Pressure Between Mono- and Polyovulating Species. BIOLOGY OF REPRODUCTION 91:-(2014).
