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GH2

Official Full Name

growth hormone 2
Overview

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency.
Synonyms

GH2; growth hormone 2; growth hormone variant; GH V; GHL; GHV; hGH V; placenta specific growth hormone; placental specific growth hormone; GH 2; hGHV; placenta-specific growth hormone; placental-specific growth hormone; GH-V; hGH-V;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Zebrafish

Source

E.coli
HEK293
Human
In Vitro Cell Free System
Wheat Germ
Zebrafish

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GH2-941H	Recombinant Human GH2 Protein, His-tagged	E.coli	His		Inquiry
Human	GH2-29022TH	Recombinant Human GH2	E.coli	N/A		Inquiry
Human	GH2-348H	Recombinant Human Growth Hormone 2	Human	N/A		Inquiry
Human	GH2-67H	Recombinant Human Growth Hormone 2	E.coli	N/A		Inquiry
Human	GH2-292HCL	Recombinant Human GH2 lysate	HEK293	N/A		Inquiry
Human	GH2-5249HF	Recombinant Full Length Human GH2 Protein, GST-tagged	In Vitro Cell Free System	GST	27-217 amino acids	Inquiry
Human	GH2-4884H	Recombinant Human GH2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GH2-3047H	Recombinant Human GH2 Protein (Phe27-Phe217), N-His tagged	E.coli	N-His	Phe27-Phe217	Inquiry
Zebrafish	gh1-645Z	Recombinant Zebrafish Growth Hormone 1 Mutant	Zebrafish	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GH2 Related Articles
GH2 Related Research Area

GH2 involved in several pathways and played different roles in them. We selected most pathways GH2 participated on our site, such as Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cytokine-cytokine receptor interaction	IFNA17;BMP2;TNFRSF14;IFNA2;INHBB;CNTFR;CCR9;IFNB1;Kitl
Neuroactive ligand-receptor interaction	IL12;HTR1E;GRM4;PRLHR;GHR;NR3C1;SSTR1;GHRHRL;AVPR1A
PIK-Akt signaling pathway	PPP2R2A;FGFR3;NGFR;ITGAV;GNG4;THBS1;PIK3CB;IL2RA;IFNA8
Jak-STAT signaling pathway	IL4;STAT1B;PIAS4B;BCL2;PIK3R1;IFNGR1;SOCS6;IL22;IL9R

GH2 has several biochemical functions, for example, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GH2 itself. We selected most functions GH2 had, and list some proteins which have the same functions with GH2. You can find most of the proteins on our site.

Function	Related Protein
hormone activity	INSL3;PRL2A1;SCT;SST1.1;PRL7A2;GIP;UTS1;PRL4A1;FSHB

GH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GH2.

Cairns, TM; Friedman, LS; et al. N-terminal mutants of herpes simplex virus type 2 gH are transported without gL but require gL for function. JOURNAL OF VIROLOGY 81:5102-5111(2007).

Blouzard, JC; Bourgeois, C; et al. Enzyme diversity of the cellulolytic system produced by Clostridium cellulolyticum explored by two-dimensional analysis: Identification of seven genes encoding new dockerin-containing proteins. JOURNAL OF BACTERIOLOGY 189:2300-2309(2007).

Neurotransmitter Associated Enzymes