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GJA8

  • Official Full Name

    gap junction protein, alpha 8, 50kDa

  • Overview

    This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.
  • Synonyms

    GJA8; gap junction protein, alpha 8, 50kDa; CAE, CAE1, CZP1, gap junction protein, alpha 8, 50kD (connexin 50) , gap junction protein, alpha 8, 50kDa (connexin 50); gap junction alpha-8 protein; connexin 50; CX50; connexin-50; lens fiber protein MP70; c;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GJA8-495H Recombinant Human GJA8 Mammalian Cell His
Human GJA8-4924H Recombinant Human GJA8 Protein, GST-tagged Wheat Germ GST
Human GJA8-1535H Recombinant Human GJA8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GJA8-3033H-B Recombinant Human GJA8 Protein Pre-coupled Magnetic Beads HEK293
Human GJA8-3033H Recombinant Human GJA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GJA8-5292HF Recombinant Full Length Human GJA8 Protein, GST-tagged In Vitro Cell Free System GST 433 amino acids
Mouse GJA8-6372M Recombinant Mouse GJA8 Protein Mammalian Cell His
Mouse GJA8-3573M Recombinant Mouse GJA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GJA8-3573M-B Recombinant Mouse GJA8 Protein Pre-coupled Magnetic Beads HEK293
Mouse Gja8-3217M Recombinant Mouse Gja8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Gallus gallus (Chicken) RFL22066GF Recombinant Full Length Chicken Gap Junction Alpha-8 Protein(Gja8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-400)
Homo sapiens (Human) RFL36104HF Recombinant Full Length Human Gap Junction Alpha-8 Protein(Gja8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-433)
Mus musculus (Mouse) RFL32305MF Recombinant Full Length Mouse Gap Junction Alpha-8 Protein(Gja8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-440)
Ovis aries (Sheep) RFL8496OF Recombinant Full Length Sheep Gap Junction Alpha-8 Protein(Gja8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-440)
Rattus norvegicus (Rat) RFL553RF Recombinant Full Length Rat Gap Junction Alpha-8 Protein(Gja8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-440)
Chicken GJA8-6555C Recombinant Chicken GJA8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GJA8 Related Articles

GJA8 involved in several pathways and played different roles in them. We selected most pathways GJA8 participated on our site, such as Calcium Regulation in the Cardiac Cell, Gap junction assembly, Gap junction trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with GJA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium Regulation in the Cardiac CellCASQ1;GJA10;CX34.4;RGS5B;PKIB;GJB3;CX27.5;GNG13B;CASQ1B
Gap junction assemblyGJB4;GJB7;GJA5;GJA8;GJB5;GJD3;GJB2;GJC1;GJB3
Gap junction traffickingMYO6B;DAB2;GJA4;GJB4;CX30.3;GJB3;CX27.5;GJB2;GJB7
Gap junction trafficking and regulationGJA5;MYO6A;GJD3;CX30.3;GJB3;DAB2;GJB4;MYO6;MYO6B
Membrane TraffickingTRAPPC9;HIP1R;HIP1RB;SEC23IP;BLOC1S3;COPB2;GAK;ANKRD28;NAPAB
Vesicle-mediated transportNAPB;CLVS1;CX30.3;HPX;BLOC1S1;PICALM;GJD3;PICALMA;BLOC1S4

GJA8 has several biochemical functions, for example, channel activity, gap junction channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GJA8 itself. We selected most functions GJA8 had, and list some proteins which have the same functions with GJA8. You can find most of the proteins on our site.

Function Related Protein
channel activitySTEAP1;CHRNB1;APNL;BCL2;BAXA;BAXB;MAL;PANX1B;P2RX6
gap junction channel activityCX23;GJC2;GJD3;GJA10;CX30.3;CX43;PANX2;GJB3;CX52.6

GJA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJA8.

Zhu, YN; Yu, H; et al. A Novel GJA8 Mutation (p.V44A) Causing Autosomal Dominant Congenital Cataract. PLOS ONE 9:-(2014).
Chen, JH; Qiu, J; et al. Rapid and cost-effective molecular diagnosis using exome sequencing of one proband with autosomal dominant congenital cataract. EYE 28:1511-1516(2014).
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