|Official Full Name||gap junction protein, alpha 8, 50kDa|
|Background||This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.|
|Synonyms||GJA8; gap junction protein, alpha 8, 50kDa; CAE, CAE1, CZP1, gap junction protein, alpha 8, 50kD (connexin 50) , gap junction protein, alpha 8, 50kDa (connexin 50); gap junction alpha-8 protein; connexin 50; CX50; connexin-50; lens fiber protein MP70; c|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
gja8 involved in several pathways and played different roles in them. We selected most pathways gja8 participated on our site, such as Calcium Regulation in the Cardiac Cell, Gap junction assembly, Gap junction trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with gja8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Calcium Regulation in the Cardiac Cell||GNB3B; RGS4; GJB4; GJB2; RGS5; GJB6; KCNJ5; GJA4; CHRM2; CCDC102A|
|Gap junction assembly||GJA4; GJB4; GJD3; GJB2; GJC1; GJB5; GJA8; GJA5; GJB3; GJB7|
|Gap junction trafficking||MYO6B; GJD3; GJA5; CX27.5; GJB5; GJB4; GJA8; GJB3; CX30.3; DAB2|
|Gap junction trafficking and regulation||DAB2; GJC1; GJB3; CX27.5; GJA5; GJB5; MYO6; MYO6A; GJA8; MYO6B|
|Membrane Trafficking||CTSZ; AP4B1; BLOC1S3; EXOC1; ARCN1; CTAGE5; SNX9A; PREB; EXOC8; GJD3|
|Vesicle-mediated transport||GJA5; PICALMB; COPB2; SEC22A; TPD52L1; FTH1A; GJD3; CLINT1; GJB7; GAK|
gja8 has several biochemical functions, for example, channel activity, gap junction channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by gja8 itself. We selected most functions gja8 had, and list some proteins which have the same functions with gja8. You can find most of the proteins on our site.
|channel activity||BCL2; TRPA1; CHRNB1; BAXA; PANX2; BAX; GJA8; P2RX6; PANX1A; APNL|
|gap junction channel activity||GJC1; CX43; CX30.3; CX52.6; GJA10; GJA8; CX23; GJC2; PANX2; GJD3|
gja8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gja8 here. Most of them are supplied by our site. Hope this information will be useful for your research of gja8.