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Official Full Name gap junction protein, alpha 8, 50kDa
Background This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.
Synonyms GJA8; gap junction protein, alpha 8, 50kDa; CAE, CAE1, CZP1, gap junction protein, alpha 8, 50kD (connexin 50) , gap junction protein, alpha 8, 50kDa (connexin 50); gap junction alpha-8 protein; connexin 50; CX50; connexin-50; lens fiber protein MP70; c
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GJA8-1535H Recombinant Human GJA8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human GJA8-4924H Recombinant Human GJA8 Protein, GST-tagged Wheat Germ GST
    Human GJA8-495H Recombinant Human GJA8 Mammalian Cell His
    Mouse Gja8-3217M Recombinant Mouse Gja8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse GJA8-6372M Recombinant Mouse GJA8 Protein Mammalian Cell His
    Chicken GJA8-6555C Recombinant Chicken GJA8 Mammalian Cell His

    gja8 involved in several pathways and played different roles in them. We selected most pathways gja8 participated on our site, such as Calcium Regulation in the Cardiac Cell, Gap junction assembly, Gap junction trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with gja8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium Regulation in the Cardiac Cell GNB3B; RGS4; GJB4; GJB2; RGS5; GJB6; KCNJ5; GJA4; CHRM2; CCDC102A
    Gap junction assembly GJA4; GJB4; GJD3; GJB2; GJC1; GJB5; GJA8; GJA5; GJB3; GJB7
    Gap junction trafficking MYO6B; GJD3; GJA5; CX27.5; GJB5; GJB4; GJA8; GJB3; CX30.3; DAB2
    Gap junction trafficking and regulation DAB2; GJC1; GJB3; CX27.5; GJA5; GJB5; MYO6; MYO6A; GJA8; MYO6B
    Membrane Trafficking CTSZ; AP4B1; BLOC1S3; EXOC1; ARCN1; CTAGE5; SNX9A; PREB; EXOC8; GJD3
    Vesicle-mediated transport GJA5; PICALMB; COPB2; SEC22A; TPD52L1; FTH1A; GJD3; CLINT1; GJB7; GAK

    gja8 has several biochemical functions, for example, channel activity, gap junction channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by gja8 itself. We selected most functions gja8 had, and list some proteins which have the same functions with gja8. You can find most of the proteins on our site.

    Function Related Protein
    channel activity BCL2; TRPA1; CHRNB1; BAXA; PANX2; BAX; GJA8; P2RX6; PANX1A; APNL
    gap junction channel activity GJC1; CX43; CX30.3; CX52.6; GJA10; GJA8; CX23; GJC2; PANX2; GJD3

    gja8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gja8 here. Most of them are supplied by our site. Hope this information will be useful for your research of gja8.

    Zhu, YN; Yu, H; et al. A Novel GJA8 Mutation (p.V44A) Causing Autosomal Dominant Congenital Cataract. PLOS ONE 9:-(2014).
    Chen, JH; Qiu, J; et al. Rapid and cost-effective molecular diagnosis using exome sequencing of one proband with autosomal dominant congenital cataract. EYE 28:1511-1516(2014).

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