gli3
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  • Official Full Name
  • GLI family zinc finger 3
  • Background
  • This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
  • Synonyms
  • GLI3; GLI family zinc finger 3; GCPS, GLI Kruppel family member GLI3 , glioma associated oncogene family zinc finger 3 , Greig cephalopolysyndactyly syndrome , PHS; transcriptional activator GLI3; ACLS; DNA binding protein; oncogene GLI3; PAP A; PAPA
Cat.#:GLI3-4956HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GLI3 Protein, GST-tagged
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Cat.#:GLI3-1707HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLI3 protein, His & T7-tagged
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Cat.#:Gli3-1708MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gli3 protein, His & T7-tagged
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Cat.#:GLI3-4675CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GLI3
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Cat.#:GLI3-11747ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GLI3
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Cat.#:GLI3-5904HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GLI3 293 Cell Lysate
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Involved Pathway

GLI3 involved in several pathways and played different roles in them. We selected most pathways GLI3 participated on our site, such as cAMP signaling pathway, Hedgehog signaling pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
GPR81; RAP1A; MAPK10; BDNF; SLC9A1; HHIP; FFAR2; GRIN2C; EP300; GRIN3A
Hedgehog signaling pathway
FBXW11B; SHHB; BTRC; Shh; BMP2B; CSNK1DA; WNT1; HHIP; FBXW11; SKI
Pathways in cancer
PTGS2; Fzd4; GLI3; GNG13; Fasl; WNT4; LAMA3; COL4A1; BID; MAPK8
Basal cell carcinoma
AXIN1; WNT16; FZD10; DVL2; FZD6; WNT2; STK36; BMP4; AXIN2; FZD9

Protein Function

GLI3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, beta-catenin binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI3 itself. We selected most functions GLI3 had, and list some proteins which have the same functions with GLI3. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ETV6; GMEB2; ZNF257; CTCFL; TBX3; PPARA; HOXA7; NR5A2; NRF1; HAND1
Function beta-catenin binding
Related Protein TCF7; CDH1; DACT3; SLC9A3R1; PTPRU; HDAC6; CARM1; TAX1BP3; SMAD3; SALL1
Function chromatin binding
Related Protein ARID3A; MSH6; TBL1Y; PCNA; NSBP1; DMRT1; CHD8; MBD1; PBRM1L; HDAC7A
Function histone acetyltransferase binding
Related Protein TAF7; ETS1; PCNA; TP53; TAF7L; TRP53; KAT2B; GLI3; FOXP3; MTF1
Function histone deacetylase binding
Related Protein MEF2D; ANKRA2; HDAC10; PHB; HIF1A; ZNF703; HIC1; NR2C1; CEBPA; SIRT2
Function metal ion binding
Related Protein CA4B; PFKL; MZF1; VAV3; ZNF187; ZNF460; CMAH; ANTXR1; MAN1A; CDKAL1
Function protein binding
Related Protein CDC26; WDFY2; DNAJC28; USP12; CYB5R1; SLC8A1; GK; RYR2; RABGGTB; FRMD6
Function transcription factor activity, sequence-specific DNA binding
Related Protein FLI1B; SS18L1; NR5A1A; TFAM; ATF6; ZNF821; UBN2; ZSCAN20; FOSL2; MLLT10
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MEIS3; KLF4; FOXC2; TTC6; POU2F2; HOXA5; FIGLA; DLX3; SMAD4; HMGA2

Interacting Protein

GLI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI3.
SUFU; STK36; Zic1; Zic2; SMAD1; Zic3; Pias1; q8cln9_yerpe; Sufu; YWHAE