GLI3
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Official Full Name
GLI family zinc finger 3
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Overview
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. -
Synonyms
GLI3; GLI family zinc finger 3; GCPS, GLI Kruppel family member GLI3 , glioma associated oncogene family zinc finger 3 , Greig cephalopolysyndactyly syndrome , PHS; transcriptional activator GLI3; ACLS; DNA binding protein; oncogene GLI3; PAP A; PAPA;
- Cell & Tissue Lysates
- Recombinant Proteins
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His|T7
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | GLI3-5904HCL | Recombinant Human GLI3 293 Cell Lysate | HEK293 | N/A |
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| Human | GLI3-4956H | Recombinant Human GLI3 Protein, GST-tagged | Wheat Germ | GST |
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| Human | GLI3-1707H | Recombinant Human GLI3 protein, His & T7-tagged | E.coli | His/T7 | Met111~Ser343 (Accession # P10071) |
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| Human | GLI3-2338H | Recombinant Human GLI3 Protein (Met111-Ser343), N-His tagged | E.coli | N-His | Met111-Ser343 |
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| Mouse | Gli3-1708M | Recombinant Mouse Gli3 protein, His & T7-tagged | E.coli | His/T7 | Ser303~Glu561 (Accession # Q61602) |
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| Zebrafish | GLI3-11747Z | Recombinant Zebrafish GLI3 | Mammalian Cell | His |
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| Chicken | GLI3-4675C | Recombinant Chicken GLI3 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
GLI3 involved in several pathways and played different roles in them. We selected most pathways GLI3 participated on our site, such as cAMP signaling pathway, Hedgehog signaling pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | RAP1B;RYR2;ATP1B3;HTR1A;PLD1;PAK1;ACOX3;PIK3CA;HCN4 |
| Hedgehog signaling pathway | SAP18;FBXW11B;HHIP;SMO;WNT5B;PRKACB;PRKACA;PTCH2;WNT2BA |
| Pathways in cancer | MMP9;IKBKB;MAPK8;FLT3LG;FGF19;CDH1;RALGDS;ITGA2B;FGFR1 |
| Basal cell carcinoma | WNT11;WNT7A;TCF7L2;WNT7B;WNT5B;DVL2;GLI2;GSK3B;WNT3A |
GLI3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, beta-catenin binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI3 itself. We selected most functions GLI3 had, and list some proteins which have the same functions with GLI3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | FOXI1;HLTF;RFX3;BATF2;RFX2;PRDM5;TFAP2A;OTX2;PPARA |
| beta-catenin binding | PTPRJ;GSK3B;TAX1BP3;TBL1X;KDM6B;VCL;APC;PTPRU;SHROOM2 |
| chromatin binding | HDAC7A;TRIM37;HMGB1;NCOA3;MSL1;POU4F2;TOX4;MEF2C;PCNA |
| histone acetyltransferase binding | TRIP4;EGR1;CITED2;MYOCD;TP53;HIF1A;MTF1;EID1;KAT2B |
| histone deacetylase binding | KLF4;MAGEA2B;FOXP3;HEY2;NCOR1;NIPBL;HIC1;CBX5;ZMYND15 |
| metal ion binding | ZNF878;ZFP367;ZFP687;FHL1A;ZGPAT;BMPR1A;CD209;ZNF740;CYB5R4 |
| protein binding | TLE2;PTGFRN;C11orf65;SIX3;KLHL12;ARHGEF7;EDNRB;SLIT2;NLRP2 |
| transcription factor activity, sequence-specific DNA binding | ZFP746;BATF;TADA3;ZNF165;NFE2L1B;NME2;FOXN4;JUNBA;RORC |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PAX5;BCL11B;TRP53;EBF4;SRF;NR4A1;NPAS4;TP73;RBPJ |
GLI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI3.
SUFU; STK36; Zic1; Zic2; SMAD1; Zic3; Pias1; q8cln9_yerpe; Sufu; YWHAE
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