GRIP1
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Official Full Name
glutamate receptor interacting protein 1 -
Overview
This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
GRIP1;glutamate receptor interacting protein 1;glutamate receptor-interacting protein 1;GRIP-1;AMPA receptor-interacting protein GRIP1
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Wheat Germ
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- T7
- Non
- Avi
- Fc
Involved Pathway
GRIP1 involved in several pathways and played different roles in them. We selected most pathways GRIP1 participated on our site, such as BDNF signaling pathway,Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity,Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | KCNMA1,PPFIA1,KCNC1,CACNB4B,SLC18A3A,KCNJ1A.6,RAB3AB,KCNK2,KCNK7,HAND2 |
| Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | NSFB,PICK1,AKAP5,MYO6,CACNG2,CACNG3,HAND2,NSFA |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | CAMKK1B,CHRND,DLG1L,MYO6,NSFA,CHRNA2,AKAP5,CHRNE,NSFB,PICK1 |
| BDNF signaling pathway | CDK5,LINGO1,EIF4EBP1,JAK2,MAP3K2,EIF2S1,KCNN2,YBX1,CSNK2A1,DOK5 |
| Trafficking of AMPA receptors | HAND2,PICK1 |
| Trafficking of GluR2-containing AMPA receptors | PICK1,HAND2 |
| Transmission across Chemical Synapses | RAB3AA,SLC18A3A,RERG,PPFIA1,SYT1A,SLC1A3B,SYN1,SNAP25A,PICK1,SYN3 |
Protein Function
GRIP1 has several biochemical functions, for example, androgen receptor binding,beta-catenin binding,glucocorticoid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIP1 itself. We selected most functions GRIP1 had, and list some proteins which have the same functions with GRIP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | TRP53,HIC2,C11orf60,DLG3,BAIAP2,PCGF1,NEIL1,PFKM,SHANK1,VGLL3 |
| glucocorticoid receptor binding | YWHAH,NR4A2,FKBP4,NRIP1,ETS2,CEBPB,STAT5B,EP300,STAT3 |
| beta-catenin binding | GLI3,APC,CTNNA3,SALL1,HDAC6,CDH24,BCL9L,VCL,TRPC4,ASH2L |
| transcription coactivator activity | CCAR1,BCL10,NFYC,ACTL6B,RNF4,PML,RAP2C,TAF10,CEBPA,MED17 |
| androgen receptor binding | NCOA1,DAXX,NRIP1,PRKCBB,CDK7,SMARCA4,BRCA1,Ar,RNF6,RB1 |
| protein binding | KIAA1737,EED,PKP4,DDX21,NVL,NGFRB,EFCAB12,HIST1H4H,EGF,TCEB1 |
| receptor signaling complex scaffold activity | GRIP2A,ROPN1B,G3BP2,MAPK8IP3,CD3E,SPAG9A,SPAG9,LRRK2,NCK1,MAGI2 |
Interacting Protein
GRIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIP1.
ESR1;PSMB9;IRF3;KANK2;NR3C1;PRLHR;NCOA1;ZYX;PRKD2;YWHAB;Lats2;NCOA3
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References
- Dobroyolna, J; Chinenov, Y; et al. Glucocorticoid-Dependent Phosphorylation of the Transcriptional Coregulator GRIP1. MOLECULAR AND CELLULAR BIOLOGY 32:730-739(2012).
- Selak, S; Paternain, AV; et al. A Role for SNAP25 in Internalization of Kainate Receptors and Synaptic Plasticity. NEURON 63:357-371(2009).
