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Official Full Name general transcription factor IIB
Background This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]
Synonyms GTF2B; general transcription factor IIB; TF2B; TFIIB; transcription initiation factor IIB; S300-II; general transcription factor TFIIB; RNA polymerase II transcription factor IIB;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GTF2B-1176H Recombinant Human General Transcription Factor IIB E.coli N/A
    Human GTF2B-1177H Recombinant Human General Transcription Factor IIB, GST-tagged E.coli GST
    Human GTF2B-13590H Recombinant Human GTF2B, GST-tagged E.coli GST
    Human GTF2B-1831H Recombinant Human General Transcription Factor IIB, His tagged E.coli His
    Human GTF2B-30661TH Recombinant Human GTF2B, His-tagged E.coli His
    Human GTF2B-30662TH Recombinant Human GTF2B E.coli N/A
    Human GTF2B-3120H Recombinant Human GTF2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human GTF2B-4440H Recombinant Human GTF2B Protein, GST-tagged Wheat Germ GST
    Human GTF2B-5018H Recombinant Human General Transcription Factor II, His-tagged Human His
    Human GTF2B-5703HCL Recombinant Human GTF2B 293 Cell Lysate HEK293 N/A
    Mouse Gtf2b-3323M Recombinant Mouse Gtf2b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse GTF2B-7353M Recombinant Mouse GTF2B Protein Mammalian Cell His
    Rat GTF2B-2741R Recombinant Rat GTF2B Protein Mammalian Cell His
    Rhesus Macaque GTF2B-2002R Recombinant Rhesus monkey GTF2B Protein, His-tagged Mammalian Cell His
    Zebrafish GTF2B-10094Z Recombinant Zebrafish GTF2B Mammalian Cell His

    gtf2b involved in several pathways and played different roles in them. We selected most pathways gtf2b participated on our site, such as Basal transcription factors, Epstein-Barr virus infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with gtf2b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Basal transcription factors GTF2A2; TAF1; TAF8; GTF2A1; GTF2H2C_2; TAF13; TBPL2; TBP; TAF6L; TAF5L
    Epstein-Barr virus infection CCNA1; MAP2K6; POLR3C; DDX58; HLA-DQB1; MDM2; HSPA2; MAPK8; TAB1; CDK1
    Viral carcinogenesis HIST1H4G; EGR3; STAT3; HIST1H4B; SYK; BAX; PIK3R2; GSN; GTF2E2; PIK3R5

    gtf2b has several biochemical functions, for example, core promoter binding, protein binding, thyroid hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by gtf2b itself. We selected most functions gtf2b had, and list some proteins which have the same functions with gtf2b. You can find most of the proteins on our site.

    Function Related Protein
    core promoter binding E2F3; NPAS2; E2F8; E2F7; KDM3A; HDAC1; NKX3; SFPI1; GADD45A; IFI16
    protein binding PDZD11; CD300LG; PDGFRB; RAB2A; HMOX1; PRELID1; CPSF4; MLPH; SOX13; APPL2
    thyroid hormone receptor binding MED12; MED1; MED4; MED16; GTF2B; GAS2L1; NR0B2; NCOA3; NCOR1; TRIP12
    transcription factor binding TBL1X; FOS; NR0B2A; JUNBA; ADD1; PPP1R13B; BCL3; HDAC1; TP53; MAPK9
    zinc ion binding ARIH2; ZFP330; ERAP1; RGN; SPRYD5; RNF128A; ZDHHC17; ZNF253; LNPEP; CPA2

    gtf2b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gtf2b here. Most of them are supplied by our site. Hope this information will be useful for your research of gtf2b.

    E2; E2; DRAP1; TNIP1; lt_sv40; NR2F1; Vdr; GTF2F2

    Sayed, D; Yang, Z; et al. In Vivo Targeting Of GTF2B Selectively Inhibits Transcription Of Cardiomyopathy-related Genes And Partially Blunts Development Of Cardiac Hypertrophy. CIRCULATION RESEARCH 113:-(2013).
    Faresse, NJ; Canella, D; et al. Genomic Study of RNA Polymerase II and III SNAP(c)-Bound Promoters Reveals a Gene Transcribed by Both Enzymes and a Broad Use of Common Activators. PLOS GENETICS 8:-(2012).

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