GUCY1A3

  • Official Full Name

    guanylate cyclase 1, soluble, alpha 3
  • Overview

    soluble guanylate cyclase subunit that forms a heterodimer with Gucy1b3; may also function as an intracellular nitric oxide receptor [RGD, Feb 2006]
  • Synonyms

    GUCY1A3;guanylate cyclase 1, soluble, alpha 3;SGC;Gucy1a1;guanylate cyclase soluble subunit alpha-3;GCS-alpha-1;GCS-alpha-3;soluble guanylate cyclase large subunit;Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase);Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase)

Recombinant Proteins

  • Zebrafish
  • Human
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • Sf9 Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
GUCY1A3-2478Z Recombinant Zebrafish GUCY1A3 Mammalian Cells Zebrafish His
GUCY1A3-4489H Recombinant Human GUCY1A3 Protein, GST-tagged Wheat Germ Human GST
GUCY1A3-627H Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3, His-tagged Sf9 Cells Human His
GUCY1A3-7388M Recombinant Mouse GUCY1A3 Protein Mammalian Cells Mouse His
GUCY1A3-5677HCL Recombinant Human GUCY1A3 293 Cell Lysate HEK293 Human Non
GUCY1A3-3345HF Recombinant Full Length Human GUCY1A3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 690 amino acids
GUCY1A3-4009M Recombinant Mouse GUCY1A3 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
GUCY1A3-4009M-B Recombinant Mouse GUCY1A3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    GUCY1A3 involved in several pathways and played different roles in them. We selected most pathways GUCY1A3 participated on our site, such as Purine metabolism,cGMP-PKG signaling pathway,Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUCY1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism TM9SF1,NME4,NUDT2,NT5M,URAH,NME6,GUCY2E,GDA,AK2,NT5C1A
    Circadian entrainment GNAI3,PRKACG,MTNR1B,RYR1,MTNR1A,PRKG2,PRKACB,PER1,GRIA4,MAPK3
    Salivary secretion ATP2B4,CALM1,BEST2,Adcy4,VAMP2,ATP1B3,CALML5,AMY1B,CST1,CST5
    Gap junction PLCB2,GNAI2B,GNA11,ITPR1,MAP2K2A,CX43,TUBA4L,PRKCBA,ADCY2B,GNA15.1
    cGMP-PKG signaling pathway NOS3,PLCB2,INS,CALM3,IRS2,PPP3R2,INS2,CALML5,ATP2A3,SRF
    Renin secretion GNAI2,CALML3,GNAQ,REN2,PPP3CC,ACE,CLCA4,PLCB1,PRKACA,PDE3B
    Vascular smooth muscle contraction GNA13A,ADCY2B,CALM2,CALD1,PRKACBB,PPP1R14AB,CACNA1D,EDNRAA,CALML5,PLA2G1B
    Long-term depression GNA12,PLA2G4D,IGF1R,BRAF,ARAF,GNAI3,PRKCA,RAF1,PRKG1,GRM1
    Oxytocin signaling pathway PPP1R12A,GNAS,PRKAB2,PLCB3,PPP3CB,NPR2,PRKCB,MYLK,MYL9,CACNA2D2

    Protein Function

    GUCY1A3 has several biochemical functions, for example, GTP binding,NOT adenylate cyclase activity,guanylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUCY1A3 itself. We selected most functions GUCY1A3 had, and list some proteins which have the same functions with GUCY1A3. You can find most of the proteins on our site.

    Function Related Protein
    receptor activity CMKLR1,NOTCH1A,CD200,VMN1R41,GABRA5,ABP1,CRLF1,F2RL1,MED12,SEMA4D
    heme binding STC2,CYP2K18,CYGB1,NGB,CYP4F14,CYP7B1,CYP2S1,PTGIS,FECH,CYP2U1
    protein binding S100A13,KEL,CD37,AKR1C1,FGD2,MAPK15,C5orf30,BNIP3,SPSB1,MED23
    protein heterodimerization activity TOP2B,RRAGA,MAP3K7,CA,POLA2,IRAK2,SMC4,NFYBB,JDP2,DMRT1
    guanylate cyclase activity GUCY2F,GUCY2C,GC3,GUCY1B3,NPR2,GUCY2E,NPR1A,GC2,NPR1
    GTP binding TUBB2,SEPT9,RND1L,TUBA8L2,DIRAS3,GTPBP8,RAB9B,RRAGCB,RRAD,EHD2
    NOT adenylate cyclase activity GUCY2F,NPR1A,NPR2,GC3,NPR1,GUCY2C,GC2,NPR3,GUCY1B3

    Interacting Protein

    GUCY1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUCY1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GUCY1A3.

    GUCY1B3;gtp;MAPK8;IKBKG

    Resources

    References

    • Fusco, DN; Brisac, C; et al. A Genetic Screen Identifies Interferon-alpha Effector Genes Required to Suppress Hepatitis C Virus Replication. GASTROENTEROLOGY 144:1438-U210(2013).
    • Priora, R; Margaritis, A; et al. In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways. PHARMACOLOGICAL RESEARCH 64:289-297(2011).

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