GUCY1A3

  • Official Full Name

    guanylate cyclase 1, soluble, alpha 3
  • Overview

    soluble guanylate cyclase subunit that forms a heterodimer with Gucy1b3; may also function as an intracellular nitric oxide receptor [RGD, Feb 2006]
  • Synonyms

    GUCY1A3;guanylate cyclase 1, soluble, alpha 3;SGC;Gucy1a1;guanylate cyclase soluble subunit alpha-3;GCS-alpha-1;GCS-alpha-3;soluble guanylate cyclase large subunit;Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase);Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase)

Recombinant Proteins

  • Zebrafish
  • Human
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • Sf9 Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
GUCY1A3-2478Z Recombinant Zebrafish GUCY1A3 Mammalian Cells Zebrafish His
GUCY1A3-4489H Recombinant Human GUCY1A3 Protein, GST-tagged Wheat Germ Human GST
GUCY1A3-627H Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3, His-tagged Sf9 Cells Human His
GUCY1A3-7388M Recombinant Mouse GUCY1A3 Protein Mammalian Cells Mouse His
GUCY1A3-5677HCL Recombinant Human GUCY1A3 293 Cell Lysate HEK293 Human Non
GUCY1A3-3345HF Recombinant Full Length Human GUCY1A3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 690 amino acids
GUCY1A3-4009M Recombinant Mouse GUCY1A3 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
GUCY1A3-4009M-B Recombinant Mouse GUCY1A3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    GUCY1A3 involved in several pathways and played different roles in them. We selected most pathways GUCY1A3 participated on our site, such as Purine metabolism,cGMP-PKG signaling pathway,Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUCY1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Platelet activation GUCY1B3,LCP2,GP9,PIK3CG,PPP1R12A,ROCK2,VAMP8,PIK3R2,GNAI3,PTGIR
    Purine metabolism AMPD2,GMPR,PDE5AB,POLR3A,POLR2G,NUDT2,PNP5A,AK2,POLA1,FHIT
    Renin secretion PDE1B,GNAQ,ITPR3,PLCB1,CALML5,GNAI1,LOC100328615,CLCA5,CALM3,CALML3
    Oxytocin signaling pathway PRKAG2,CAMK1D,FOS,MYLK3,OXTR,PPP1CC,PIK3CA,PLA2G4D,PPP3R2,CAMK1
    Gap junction PRKACAB,PDGFB,PRKG1,DRD2A,PRKACB,TUBB2A,PLCB4,MAPK1,TUBAL3,DRD1A
    cGMP-PKG signaling pathway PIK3CD,FXYD2,SLC8A2,KCNMB4,MEF2C,ATP2B1,RAF1,PRKCE,ATP1B2,MYH7
    Circadian entrainment GUCY1B3,RYR3,GNAI3,GNG7,CAMK2A,PRKG1,GNB4,GNB2,GRIA2,NOS1AP
    Salivary secretion AQP5,ATP1A4,ATP2B1,HTN1,ITPR3,NOS1,ATP1B2,SLC9A1,AMY1B,CALM2
    Vascular smooth muscle contraction MYL9B,CALM4,ROCK2,PPP1CAB,KCNMB1,MYLK,MYL9A,AGTR1A,MAPK1,CALML3

    Protein Function

    GUCY1A3 has several biochemical functions, for example, GTP binding,NOT adenylate cyclase activity,guanylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUCY1A3 itself. We selected most functions GUCY1A3 had, and list some proteins which have the same functions with GUCY1A3. You can find most of the proteins on our site.

    Function Related Protein
    guanylate cyclase activity NPR1,GUCY2C,GUCY2E,GUCY2F,GC3,NPR2,GC2,GUCY1B3,NPR1A
    protein binding ILVBL,CBLB,ACOT7,TNP1,CAPRIN2,C18orf1,TRPC7,FNBP1,RRP8,FBXL3
    NOT adenylate cyclase activity GC3,NPR2,GUCY1B3,GUCY2F,NPR1,NPR3,GC2,NPR1A,GUCY2C
    protein heterodimerization activity SYT10,UGT1A1,TGFB1,MAFA,MCL1,BOKB,HIST4H4,HIST1H4J,HIST1H4G,SYCP3
    heme binding CYP3C1L2,CYP24A1,CYP1B1,CYP3A43,CYP4A10,IRGM1,CYGB2,CYP2C50,CYP2C37,FAM84B
    receptor activity NPC1,P2RY1,RTN4RL2,PVRL3B,V1RA8,ABP1,ANPEP,ITGB1B.1,TNFRSF17,NOTCH1B
    GTP binding IRGF4,RAB5AA,TUBB2A,GUCY1B3,GTPBP10,RAB18,GNA11B,C9orf86,IRGC,RAB17

    Interacting Protein

    GUCY1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUCY1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GUCY1A3.

    GUCY1B3;gtp;MAPK8;IKBKG

    Resources

    References

    • Fusco, DN; Brisac, C; et al. A Genetic Screen Identifies Interferon-alpha Effector Genes Required to Suppress Hepatitis C Virus Replication. GASTROENTEROLOGY 144:1438-U210(2013).
    • Priora, R; Margaritis, A; et al. In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways. PHARMACOLOGICAL RESEARCH 64:289-297(2011).

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