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GUCY1B3

Official Full Name

Guanylate cyclase 1, soluble, beta 3
Overview

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene. Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
Synonyms

GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B1; GC-S-beta-1; GUCY1B3; GCS-beta-1; GCS-beta-3; guanylate cyclase 1, soluble, beta 3; guanylate cyclase soluble subunit beta-1; Guanylate cyclase soluble subunit beta-3; Soluble guanylate cyclase small subunit;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GUCY1B3-13619H	Recombinant Human GUCY1B3, His-tagged	E.coli	His	282-619a.a.	$319 / 25ug
Human	GUCY1B3-4491H	Recombinant Human GUCY1B3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GUCY1B3-5676HCL	Recombinant Human GUCY1B3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GUCY1B3-3347HF	Recombinant Full Length Human GUCY1B3 Protein, GST-tagged	In Vitro Cell Free System	GST	619 amino acids	Inquiry
Rat	GUCY1B3-2755R	Recombinant Rat GUCY1B3 Protein	Mammalian Cell	His		Inquiry
Rat	GUCY1B3-2409R	Recombinant Rat GUCY1B3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GUCY1B3-2409R-B	Recombinant Rat GUCY1B3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	GUCY1B3-2019R	Recombinant Rhesus monkey GUCY1B3 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	GUCY1B3-1840R	Recombinant Rhesus Macaque GUCY1B3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	GUCY1B3-1840R-B	Recombinant Rhesus Macaque GUCY1B3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	GUCY1B3-8100Z	Recombinant Zebrafish GUCY1B3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

GUCY1B3 involved in several pathways and played different roles in them. We selected most pathways GUCY1B3 participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUCY1B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	NME5;PRPS2;ADKA;ENTPD1;ENTPD3;PDE1C;POLR3B;NT5C1A;NUDT16
cGMP-PKG signaling pathway	KCNJ8;GTF2IRD1;PDE3A;SLC25A5;ITPR1;ATP1B1;AKT1;ATP1B2;CREB3L3
Vascular smooth muscle contraction	PPP1CAB;CACNA1SA;GUCY1A3;MAP2K1;PLA2G2D;PLA2G1B;CALML3;PLCB3;MYL6
Gap junction	TUBB6;GNA11B;TUBA3B;GNAI2A;CSNK1DA;DRD1B;PRKACBA;TUBA4L;ITPR3
Platelet activation	ACTG1;PLCB1;MAPK3;SNAP23;ITGB3;ORAI1;PRKCI;MYL12B;P2RY1
Circadian entrainment	GNG11;PRKACB;GNB1;MTNR1A;CAMK2G;CALM3;CACNA1H;GRIA4;CALML3
Long-term depression	PRKCG;PPP2R1B;PLCB2;GNA13;ITPR1;PPP2CB;GNAI2;MAP2K2;NOS1
Oxytocin signaling pathway	MYL9;CALM3;PLA2G4C;GNAS;PRKACG;Adcy4;PIK3R1;ROCK2;SRC
Renin secretion	ITPR1;GNAQ;AQP1;PDE3B;GUCY1A3;AGTR1A;PRKG2;PPP3R2;AGTR1B
Salivary secretion	CALM2;DMBT1;VAMP2;KCNN4;CST2;PLCB3;PRKCB;LYZ2;PLCB2

GUCY1B3 has several biochemical functions, for example, GTP binding, NOT adenylate cyclase activity, guanylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUCY1B3 itself. We selected most functions GUCY1B3 had, and list some proteins which have the same functions with GUCY1B3. You can find most of the proteins on our site.

Function	Related Protein
GTP binding	RAB1;RERGLA;HBS1L;TUBA8;GMPPAA;SRL;GBP1;ARF4B;SUCLG2
NOT adenylate cyclase activity	GUCY1A3;NPR1A;GUCY2C;GC3;GUCY1B3;GUCY2F;GC2;NPR2;NPR1
guanylate cyclase activity	NPR2;GUCY1B3;GUCY1A3;GC2;NPR1A;NPR1;GC3;GUCY2E;GUCY2C
heme binding	HMOX1;CYP2AD2;XGB;CYP7B1;HBAA;CYP4B1;MPX;CYP17A1;CYP2P8
metal ion binding	ZC3H8;ADPRM;DTX1;ZFP521;AGO2;ATP2A1L;ZFP2;AURKB;C1GALT1A
protein binding	CALR;TNFRSF1A;SEC14L4;STXBP1;RHEBL1;FOXO3;MRPL48;CTLA2B;MAP1B
receptor activity	PVRL1B;KLRB1F;ITGB8;ITGAX;PLXNA1;TNFRSF17;THBD;CCR6;IGSF1

GUCY1B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUCY1B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GUCY1B3.

GUCY1A3; LIN7A