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HAO2

  • Official Full Name

    hydroxyacid oxidase 2 (long chain)

  • Overview

    This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed predominantly in liver and kidney and has the highest activity toward the substrate 2-hydroxypalmitate. Two alternatively spliced variants encoding the same isoform have been described.
  • Synonyms

    HAO2; hydroxyacid oxidase 2 (long chain); hydroxyacid oxidase 2; (S) 2 hydroxy acid oxidase; GIG16; glycolate oxidase; growth inhibiting protein 16; HAOX2; long chain L 2 hydroxy acid oxidase; peroxisomal; (S)-2-hydroxy-acid oxidase; 2 hydroxy acid oxidase peroxisomal; Cell growth-inhibiting gene 16 protein; HAO 2; HAOX2_HUMAN; Long chain alpha hydroxy acid oxidase; Long chain alpha-hydroxy acid oxidase; Long-chain L-2-hydroxy acid oxidase; growth-inhibiting protein 16; (S)-2-hydroxy-acid oxidase, peroxisomal;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HAO2-4572H Recombinant Human HAO2 Protein, GST-tagged Wheat Germ GST
Human HAO2-12H Recombinant Human HAO2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HAO2-13H Recombinant Human HAO2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HAO2-5637HCL Recombinant Human HAO2 293 Cell Lysate HEK293 N/A
Human HAO2-1043H Recombinant Human HAO2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HAO2-2241H Recombinant Human HAO2 Protein (2-351 aa), His-SUMO-tagged E.coli His/SUMO 2-351 aa
Human HAO2-1515H Recombinant Human HAO2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HAO2-3352HF Recombinant Full Length Human HAO2 Protein, GST-tagged In Vitro Cell Free System GST 351 amino acids
Human HAO2-5763H Recombinant Human HAO2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HAO2-906HFL Recombinant Full Length Human HAO2 Protein, C-Flag-tagged Mammalian cells Flag
Human HAO2-1043H-B Recombinant Human HAO2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Hao2-3355M Recombinant Mouse Hao2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat HAO2-2788R Recombinant Rat HAO2 Protein Mammalian Cell His
Rat HAO2-2442R Recombinant Rat HAO2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Hao2-1615R Recombinant Rat Hao2 Protein, His-tagged E.coli N-His Pro2-Leu223
Rat HAO2-2442R-B Recombinant Rat HAO2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HAO2-10781Z Recombinant Zebrafish HAO2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HAO2 Related Articles

HAO2 involved in several pathways and played different roles in them. We selected most pathways HAO2 participated on our site, such as Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glyoxylate and dicarboxylate metabolismGLULB;HOGA1;GRHPRB;GLYCTK;AGXTA;PGP;DHDPSL;MCEE;AGXTB
Metabolic pathwaysATP6V1E1B;NAMPT;SHMT2;CYP26B1;MIBP;PKM2;PAFAH2;ALG11;CMASA
Carbon metabolismOGDHA;PSPH;PDHA2;PGP;AGXTB;PSAT1;MCEE;PFKM;GPT
PeroxisomePEX19;MPV17L;PEX11A;ABCD4;AGPS;PEX2;ACAA1A;ACSL4B;DAO.1

HAO2 has several biochemical functions, for example, (S)-2-hydroxy-acid oxidase activity, FMN binding, long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HAO2 itself. We selected most functions HAO2 had, and list some proteins which have the same functions with HAO2. You can find most of the proteins on our site.

Function Related Protein
(S)-2-hydroxy-acid oxidase activityHAO2;HAO1
FMN bindingNDOR1;NOS3;MTRR;CREG2;HAO1;NOS2A;PNPO;NOS2B;POR
long-chain-(S)-2-hydroxy-long-chain-acid oxidase activityHAO1;HAO2
medium-chain-(S)-2-hydroxy-acid oxidase activityHAO2;HAO1
receptor bindingHLA-G;HCK;PTK2BB;CD276;LRP6;AGRP;CNPY3;NMU;SNX17
very-long-chain-(S)-2-hydroxy-acid oxidase activityHAO1;HAO2

HAO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAO2.

p27958-pro_0000037576

Barawkar, DA; Bandyopadhyay, A; et al. Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22:4341-4347(2012).
Barawkar, DA; Meru, A; et al. Potent and Selective Inhibitors of Long Chain L-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats. ACS MEDICINAL CHEMISTRY LETTERS 2:919-923(2011).
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