HERC5

  • Official Full Name

    hect domain and RLD 5
  • Overview

    This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
  • Synonyms

    HERC5;hect domain and RLD 5;E3 ISG15--protein ligase HERC5;CEB1;CEBP1;HECT domain and RCC1 like domain containing protein 5;Herc6;Cyclin E binding protein 1;Cyclin-E-binding protein 1;HECT domain and RCC1-like domain-containing protein 5;HECT E3 ubiquitin ligase;HERC5_HUMAN;cyclin-E binding protein 1;probable E3 ubiquitin-protein ligase HERC5
Cat.# Product name Source (Host) Species Tag Protein Length Price
HERC5-178H Recombinant Human HERC5, His-tagged E.coli Human His 681-1024aa
HERC5-4693H Recombinant Human HERC5 Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    HERC5 involved in several pathways and played different roles in them. We selected most pathways HERC5 participated on our site, such as Antiviral mechanism by IFN-stimulated genes,Cytokine Signaling in Immune system,ISG15 antiviral mechanism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System RNF135,TRIM62,GBP5,ADAR,TRIM22,TRIM10,RAPGEF3,POLR3H,ABI1B,TNFSF13B
    ISG15 antiviral mechanism IFIT14,USP18,IFIT10,UBE2L6,ARIH1,ARIH1L,KPNA3,KPNA4,EIF4G2A,IFIT11
    Negative regulators of RIG-I/MDA5 signaling TAX1BP1,RNF135,CYLD,PCBP2,NLRC5,RNF216,TAX1BP1B
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways RNF135,NLRC5,TAX1BP1B,RNF216,TAX1BP1,PCBP2,TANK
    Antiviral mechanism by IFN-stimulated genes EIF4A2,JAK1,ARIH1,KPNA3,KPNA4,EIF4EB,EIF4E3,EIF4G2A,USP18,NUPL2
    Interferon Signaling TRIM22,ARIH1L,IRF6,IFI27,OASL,IFI30,IFIT12,TRIM2,IFIT2,IFIT14
    Innate Immune System DEFB119,CFHL1,CRCP,CASP2,CLEC5A,MAP3K8,ALCAMB,TREM1,CNPY3,S100A12
    Cytokine Signaling in Immune system EGR1,CASPB,RASGEF1A,PEA15A,EDARADD,FGFR1B,TRIM5,RASGRP4,PTPRA,HAVCR2

    Protein Function

    HERC5 has several biochemical functions, for example, ISG15 transferase activity,ligase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC5 itself. We selected most functions HERC5 had, and list some proteins which have the same functions with HERC5. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding C14orf21,ZNF326,LRRC47,MRPS15,FAM46A,CDC5L,EIF4A1,AATF,LYAR,BAG4
    protein binding ERP27,C17orf28,ZNF274,ITM2B,VAV3,CIC,FAM110C,C9orf116,GPI1,MR1
    ligase activity NEDD4L,CCNB1IP1,CPS1,MARCH9,TRIM33,BRCA1,PELI2,LTN1,LIPT2,RNF144AA
    ubiquitin protein ligase activity MARCH8,RNF34,UBE3A,HUWE1,UHRF2,UHRF1,UBE2G1,TMEM189,TOPORS,CBLC
    ISG15 transferase activity UBE2E1,UBE2L6,UBE2E2

    Interacting Protein

    HERC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC5.

    NUDCD2;UBE2E1;UBE2E3;UBE2E2;Srp72;RPL10;TTK;SNCA;HNRNPU;Mta1;GSG2;Rrbp1;Nrip3;AGO2

    Resources

    References

    • Huang, YF; Bulavin, DV; et al. Oncogene-mediated regulation of p53 ISGylation and functions. ONCOTARGET 5:5808-5818(2014).
    • Raterman, HG; Vosslamber, S; et al. The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients. ARTHRITIS RESEARCH & THERAPY 14:-(2012).
    • Malhotra, S; Bustamante, MF; et al. Search for Specific Biomarkers of IFN beta Bioactivity in Patients with Multiple Sclerosis. PLOS ONE 6:-(2011).

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