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HK1

  • Official Full Name

    Hexokinase 1

  • Overview

    Hexokinase-1 is an enzyme that in humans is encoded by the HK1 gene.
  • Synonyms

    HK1; Hexokinase 1; HK1-ta; HK1-tb; HK1-tc; HKI; HXK1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|Twin Strep
  • SUMO
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HK1-40H Active Recombinant Human HK1 protein, His-tagged, Bioactivity Validated. E.coli His
Human HK1-29228TH Recombinant Human HK1, His-tagged E.coli His
Human HK1-7652H Recombinant Human HK1 protein, His-tagged E.coli His Phe80~Met215 (Accession # P19367)
Human HK1-1141H Active Recombinant Human HK1 Protein, His-tagged E. coli His 1-917 aa
Human HK1-177H Recombinant Human HK1, His-Twin Strep-tagged HEK293 His/Twin Strep
Human HK1-13806H Recombinant Human HK1, GST-tagged E.coli GST 583-917a.a.
Human HK1-318H Recombinant Human HK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HK1-7653H Recombinant Human HK1 protein, His & GST-tagged E.coli His/GST Asp413~Val540 (Accession # P19367)
Human HK1-4821H Recombinant Human HK1 Protein, GST-tagged Wheat Germ GST
Human HK1-794HCL Recombinant Human HK1 cell lysate N/A
Human HK1-2351H Recombinant Human HK1 Protein (Phe80-Met215), His tagged E.coli His Phe80-Met215
Human HK1-3034H Recombinant Human HK1 protein, His-tagged E.coli His 13-475aa
Human HK1-1072H Recombinant Human HK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HK1-2818H Recombinant Human HK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HK1-2681H Recombinant Human HK1 protein(21-460 aa), C-His-tagged E. coli C-His 21-460 aa
Human HK1-3035H Recombinant Human HK1 protein, His-SUMO-tagged E.coli His-SUMO 476-917aa
Human HK1-5425H Recombinant Human HK1 protein, His-tagged Yeast His 13-475aa
Human HK1-1072H-B Recombinant Human HK1 Protein Pre-coupled Magnetic Beads HEK293
Human HK1-3543HF Recombinant Full Length Human HK1 Protein, GST-tagged In Vitro Cell Free System GST 917 amino acids
Human HK1-832HFL Recombinant Full Length Human HK1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Hk1-7655M Recombinant Mouse Hk1 protein, His-tagged E.coli His Ala530~Gly675 (Accession # P17710)
Mouse Hk1-7654M Recombinant Mouse Hk1 protein, His-tagged E.coli His Phe137~Leu270 (Accession # P17710)
Mouse Hk1-7656M Recombinant Mouse Hk1 protein, His-tagged E.coli His Leu676~Val800 (Accession # P17710)
Mouse Hk1-1129M Recombinant Mouse Hk1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat HK1-2861R Recombinant Rat HK1 Protein Mammalian Cell His
Rat Hk1-7657R Recombinant Rat Hk1 protein, His-tagged E.coli His Phe80~Met215 (Accession # P05708)
Rat Hk1-7658R Recombinant Rat Hk1 protein, His & GST-tagged E.coli His/GST Asp413~Val540 (Accession # P05708)
Rat HK1-2516R Recombinant Rat HK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HK1-2516R-B Recombinant Rat HK1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HK1-12451Z Recombinant Zebrafish HK1 Mammalian Cell His
Chicken HK1-5677C Recombinant Chicken HK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HK1 Related Articles
  • HK1 Related Research Area

HK1 involved in several pathways and played different roles in them. We selected most pathways HK1 participated on our site, such as Glycolysis / Gluconeogenesis, Fructose and mannose metabolism, Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisFBP1;PGK2;G6PC3;G6PCA.1;GAPDH;PFKM;ALDH3A1;LDHAL6A;ALDH3A2A
Fructose and mannose metabolismPFKMB;FBP2;PFKFB2A;DHRS13L1;ALDOC;AKR1B7;GMDS;C12orf5;AKR1B1L
Galactose metabolismAKR1B8;G6PC3;UGP2B;HKDC1;GALT;AKR1B1L;GANC;GLB1;B4GALT2
Starch and sucrose metabolismUGT2B7;HKDC1;PYGMA;PGM2;UXS1;ENPP1;AMY2B;Amy1;PYGL
Amino sugar and nucleotide sugar metabolismCYB5R1;GMPPAB;UGP2B;CYB5R2;HEXA;CHIA.3;GPIB;GPI1;GPI
Butirosin and neomycin biosynthesisHKDC1;HK1;HK2;HK3
Metabolic pathwaysPNPLA2;HMGCRA;ACAA2;PPAP2A;G6PDX;TST;ADSL;NOS2;ENPP1
Carbon metabolismAGXTB;PDHA1A;SUCLA2;SDSL;ENO1;ME1;TKTL1;ACAT2;PGAM1
HIF- signaling pathwayPLCG1;PRKCA;CUL2;TLR4;MAPK3;ANGPT4;NOX1;NFKB1;BCL2
Insulin signaling pathwayPCK1;PRKAG3B;SOCS1A;MAPK10;INPP5K;GRB2;FBP1;PHKG1B;EIF4E2RS1
Type II diabetes mellitusINSR;CACNA1G;SOCS4;IRS4;MTOR;IRS2;INS2;ADIPOQ;MAPK9
Carbohydrate digestion and absorptionATP1A4;G6PC2;HK3;PIK3R3;ATP1A1;G6PC;ATP1B1;PIK3R2;ATP1B2
Central carbon metabolism in cancerTRP53;SIRT3;SLC7A5;PDGFRA;MAPK3;MET;RET;PIK3R1;SLC2A2

HK1 has several biochemical functions, for example, ATP binding, fructokinase activity, glucokinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HK1 itself. We selected most functions HK1 had, and list some proteins which have the same functions with HK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingUBE2L3;ABCA1;TTN;PKN3;ATP1A1A.4;PRKCQ;TSSK2;NLRP10;NEK5
fructokinase activityHK3;HK1;HKDC1;HK2
glucokinase activityHK1;HK3;HK2;HKDC1
glucose bindingHK2;HK1;PYGL;UGP2;HKDC1;G6PD;SLC2A8;G6PDX;HK3
hexokinase activityHK1;HK2;HK3
mannokinase activityHK3;HKDC1;HK1;HK2
protein bindingRABGAP1L;TSHR;TRIM55;PLCB4;EPC1;GNE;HPS1;ATP6V1H;BPIFA2

HK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HK1.

ATF2; GBAS; VDAC1; MAX; ATG101; ENO2; SCMH1; MYC; ICT1; LRRK2

Norman, GL; Yang, CY; et al. Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis. LIVER INTERNATIONAL 35:642-651(2015).
Chee, J; Naran, A; et al. Expression of tissue and plasma kallikreins and kinin B-1 and B-2 receptors in lung cancer. BIOLOGICAL CHEMISTRY 389:1225-1233(2008).
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