HLA-DOB Protein


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Official Full Name major histocompatibility complex, class II, DO beta
Background HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Synonyms HLA-DOB; major histocompatibility complex, class II, DO beta; HLA class II histocompatibility antigen, DO beta chain; DO beta chain; DOB; DOB_HUMAN; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen DO beta chain; Major histocompatibility complex class II DO beta; Major histocompatibility complex class II DO beta chain; MHC class II antigen DOB
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DOB-13815H Recombinant Human HLA-DOB, GST-tagged E.coli GST
    Human HLA-DOB-190H Recombinant Human HLA-DOB, His-tagged E.coli His
    Human HLA-DOB-4839H Recombinant Human HLA-DOB Protein, GST-tagged Wheat Germ GST
    Human HLA-DOB-5504HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
    Human HLA-DOB-6413H Recombinant Human HLA-DOB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK

    HLA-DOB involved in several pathways and played different roles in them. We selected most pathways HLA-DOB participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome TLR4; RAB5AB; CD36; BLA; OLR1; HLA-DMA; CTSL1B; TLR2-1; H2-Q10; MRC1
    Cell adhesion molecules (CAMs) HLA-DRB3; CLDN10; CLDNB; HLA-B; CLDN7A; CDH15; CLDN5B; PTPRC; NCAM1A; ITGB2
    Antigen processing and presentation CD8A; IFI30; HLA-DMB; HLA-DQA2; HLA-DPA1; KLRC1; KIR2DL4; H2-AB1; CTSS; KLRD1
    Intestinal i TNFRSF13B; CXCL12A; MHC2DCB; CCL28; HLA-DMA; HLA-DPA1; BLB2; MHC2DAB; IL15RA; Icosl
    ne network for IgA production TNFSF13; CXCL12; HLA-DMB; HLA-DRB3; IL-15RA; IL15RA; ITGB7; HLA-DRB1; PIGR; TGFB1
    Type I diabetes mellitus HLA-DOB; HLA-DQA1; FASLG; Fasl; HLA-G; FAS; CD28; HLA-DOA; GAD1; CD86
    Leishmaniasis HLA-DRB3; HLA-DPA1; IL12A; HLA-DOA; CR1; NFKB1; IFNGR1; IL1B; HLA-DOB; H2-AB1
    Toxoplasmosis CASP8; NFKB1; GNAI1; Toxoplasma Gondii Dense Granule Protein 7; HLA-DOB; HSPA8; BIRC7; HLA-DRB3; LAMA2; IFNG
    Staphylococcus aureus infection C1QA; FCAR; HLA-DRB3; HLA-DRB5; ITGB2; H2-AA; FCGR2B; ITGB2L; H2-AB1; FGG
    Tuberculosis IFNA4; KSR1; NFYC; NFYA; CASP10; CORO1A; MAPK1; FCER1G; HSPD1; IFNB1
    Influenza A EIF2AK3; TYK2; MAP2K2; PIK3R3; IFNA16; IRF7; IL12B; CCL2; TMPRSS13; IFNA3
    Herpes simplex infection TBP; HLA-E; IFNB1; TRAF3; IFNA17; BLA; FB06F03; TAF3; FASLG; CASP3A
    Asthma H2-AB1; IL5; IL4; IL3; CD40; HLA-DOA; HLA-DPB1; HLA-DRB1; CCL11; MS4A2
    Autoi IFNA12; IFNA17; IFNA2; IFNA13; HLA-C; IFNA10; H2-Q10; IFNA21; CD86; Fasl
    ne thyroid disease HLA-DQA2; HLA-C; IL5; H2-AA; FAS; Fasl; TSHB; H2-AB1; IFNA12; IFNA8
    Inflammatory bowel disease (IBD) STAT6; HLA-DPB1; Il23a; Il2; IFNGR2; IL4; IL13; FOXP3; IL23R; HLA-DOB
    Systemic lupus erythematosus HIST2H4; HIST1H4B; HIST1H2AG; H3F3A; GM6026; HIST1H2AP; CD28; SNRPD1; HIST1H2BK; HIST1H3E
    Rheumatoid arthritis ITGAL; MMP3; CCL20; VEGFA; ATP6V1C2; ACP5; HLA-DQB1; CCL3; ATP6V0A1; HLA-DOA
    Allograft rejection HLA-DQA1; HLA-DMA; IL10; IL12A; IL5; HLA-DOA; HLA-G; CD40; HLA-DMB; HLA-DOB
    Graft-versus-host disease H2-AA; HLA-DOB; HLA-DMA; HLA-E; IL1A; HLA-DQA2; HLA-DRB1; Il2; HLA-DOA; HLA-DQB1
    Viral myocarditis HLA-G; CAV1; HLA-DRB5; ACTB; ICAM1; CXADR; HLA-DQA2; HLA-DQA1; ITGB2L; H2-Q10

    HLA-DOB has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DOB itself. We selected most functions HLA-DOB had, and list some proteins which have the same functions with HLA-DOB. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein complex binding ANXA11; HLA-DRA; CD81; ATP1B1; HLA-DOB; HSP90AA1; HLA-DOA; HLA-DMB; HLA-DMA; CD74
    MHC class II receptor activity HLA-DQA2; HLA-DRB4; HLA-DOB; HLA-DQB2; HLA-DPA1; HLA-DQA1; HLA-DRB3; HLA-DRA; HLA-DRB1; HLA-DQB1

    HLA-DOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DOB here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DOB.

    Yucesoy, B; Talzhanov, Y; et al. Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations. VACCINE 31:5381-5391(2013).
    van Lith, M; van Ham, M; et al. Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies. IMMUNOGENETICS 54:591-595(2002).

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