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Official Full Name major histocompatibility complex, class II, DO beta
Background HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Synonyms HLA-DOB; major histocompatibility complex, class II, DO beta; HLA class II histocompatibility antigen, DO beta chain; DO beta chain; DOB; DOB_HUMAN; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen DO beta chain; Major histocompatibility complex class II DO beta; Major histocompatibility complex class II DO beta chain; MHC class II antigen DOB
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DOB-13815H Recombinant Human HLA-DOB, GST-tagged E.coli GST
    Human HLA-DOB-190H Recombinant Human HLA-DOB, His-tagged E.coli His
    Human HLA-DOB-4839H Recombinant Human HLA-DOB Protein, GST-tagged Wheat Germ GST
    Human HLA-DOB-5504HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
    Human HLA-DOB-6413H Recombinant Human HLA-DOB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK

    HLA-DOB involved in several pathways and played different roles in them. We selected most pathways HLA-DOB participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) CLDN3; CDH1; PTPRFB; ITGB7; NEGR1; CDH3; CDH15; TIGIT; CD6; MHC1UXA2
    Antigen processing and presentation LGMN; KIR2DL1; IFI30; HLA-DRB3; HSPA4; HLA-DMA; NFYA; KIR3DL1; HLA-G; CD8B1
    Intestinal i LTBR; MHC2DAB; HLA-DPB1; IL4; IL-15RA; MHC2A; IL15RA; CCR9A; HLA-DQA2; Icosl
    ne network for IgA production CXCR4A; TGFB1; CCL27B; TNFRSF13B; BLB2; CXCL12B; IL-15RA; TGFB1A; CXCL12; H2-AA
    Type I diabetes mellitus FASLG; HLA-DRA; INS2; HLA-DOB; IFNG; TNF; Fasl; HLA-DOA; CD86; Il2
    Leishmaniasis TLR2; ITGB2; CYBA; MAPK13; MAPK12; HLA-DMB; C3; RELA; HLA-DPB1; FCGR3B
    Toxoplasmosis IFNGR2; TLR4; NOS2; LY96; HSPA8; BIRC2; HLA-DQA2; IRAK1; IRGM1; XIAP
    Staphylococcus aureus infection DSG1A; FPR1; H2-AA; C1QA; HLA-DPB1; FCGR1A; FCGR3B; MBL2; DSG1C; HLA-DMA
    Tuberculosis MAPK9; TRAF6; PMAP-36; CAMK2A; HLA-DRB4; RHOA; FADD; MAPK10; PIK3C3; ATP6V0D1
    Influenza A PIK3R1; IFNA7; LOC100033925; BLA; NXT1; AKT1; PABPN1L; PRKCA; TNFRSF10C; HSPA1L
    HTLV-I infection PIK3CA; TGFBR2; NFKB2; H2-AB1; APC; FDPS; SLC25A5; CDC23; WNT3A; PRKACG
    Herpes simplex infection IL12A; CDC34; MED8; STAT1; EEF1DB; HLA-G; MAPK8B; Ccl12; TRAF1; PTPN11B
    Autoi H2-Q10; IFNA17; IFNA2; HLA-DOB; IFNA12; IL4; Fasl; HLA-DQA1; HLA-DRB3; HLA-A
    ne thyroid disease IFNA6; HLA-G; CD28; TG; IFNA5; IFNA10; HLA-DRA; IFNA16; IFNA8; HLA-DMB
    Inflammatory bowel disease (IBD) HLA-DPB1; IL18RAP; HLA-DQA2; Il23a; Il12b; SMAD3; IL23; STAT6; IL4R; HLA-DQA1; SMAD2
    Systemic lupus erythematosus HIST2H3C1; HIST1H2BN; HIST1H2AL; GM5077; HLA-DPA1; HIST1H3C; GM14479; HIST1H2BE; GRIN2A; HIST1H2AF
    Rheumatoid arthritis H2-AA; ATP6V1G1; ACP5; TNFSF13B; TGFB3; H2-AB1; ATP6V1D; Ctsl; HLA-DRA; ATP6V0C
    Allograft rejection IL12A; TNF; HLA-F; HLA-DRB3; HLA-G; HLA-C; HLA-DMB; PRF1; HLA-DMA; Il2
    Graft-versus-host disease HLA-G; HLA-DRB3; H2-Q10; HLA-DRA; HLA-DOB; PRF1; HLA-DPA1; H2-AB1; IL6; HLA-DMA
    Viral myocarditis EIF4G3; PRF1; RAC3; HLA-DOA; CD80; CAV1; H2-Q10; ITGB2; HLA-DOB; HLA-C

    HLA-DOB has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DOB itself. We selected most functions HLA-DOB had, and list some proteins which have the same functions with HLA-DOB. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein complex binding CD74; HSP90AB1; PKM2; MS4A1; HSP90AA1; HLA-DMB; HLA-DOB; HLA-DMA; YWHAE; HLA-DRB1
    MHC class II receptor activity HLA-DRA; HLA-DQA2; HLA-DOA; HLA-DQA1; KRT17; HLA-DQB2; HLA-DPA1; HLA-DRB3; HLA-DOB; HLA-DRB1

    HLA-DOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DOB here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DOB.

    Yucesoy, B; Talzhanov, Y; et al. Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations. VACCINE 31:5381-5391(2013).
    van Lith, M; van Ham, M; et al. Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies. IMMUNOGENETICS 54:591-595(2002).

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