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Official Full Name major histocompatibility complex, class II, DP beta 1
Background HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Synonyms HLA-DPB1; major histocompatibility complex, class II, DP beta 1; HLA DP1B; HLA class II histocompatibility antigen, DP beta 1 chain; MHC HLA DPB1; HLA DP14-beta chain; MHC class II HLA-DRB1; class II HLA beta chain; MHC class II HLA-DP-beta; MHC class II
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DPB1-1278H Recombinant Human HLA-DPB1 Protein (30-223 aa), His-tagged E.coli His
    Human HLA-DPB1-30198TH Recombinant Human HLA-DPB1 Wheat Germ N/A
    Human HLA-DPB1-4841H Recombinant Human HLA-DPB1 Protein, GST-tagged Wheat Germ GST
    Human HLA-DPB1-5505HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    hla-dpb1 involved in several pathways and played different roles in them. We selected most pathways hla-dpb1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with hla-dpb1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) ICAM3; JAM3B; CLDNF; CD8B1; CLDN23; CLDND; NRXN3A; NCAM2; CLDN10A; CLDN7A
    Antigen processing and presentation RFXANK; CTSL1; CANX; HLA-DMB; KLRC2; RFXAP; HLA-DMA; KIR2DL3; TAP2; HSPA8
    Intestinal i MAP3K14; HLA-DRB4; MADCAM1; TNFSF13; ITGA4; Icosl; CXCR4; CCL28; HLA-DRB1; CXCR4B
    ne network for IgA production HLA-DRB4; BMA2; HLA-DOA; CCL25; IL5; TGFB1; CCR10; AICDA; HLA-DRB5; ICOSLG
    Type I diabetes mellitus ICA1; PTPRN; H2-AB1; HLA-E; TNF; IL1B; HLA-DRB1; INS2; CD80; HLA-DQA2
    Toxoplasmosis BCL2; HSPA1B; HSPA6; GNAI2; Toxoplasma Gondii Dense Granule Protein 7; GNAI1; BAD; MAPK8; NFKBIB; TRAF6
    Staphylococcus aureus infection FCGR3B; ICAM1; CFI; C1RA; SELP; FPR1; ITGB2L; DSG1C; FCGR1; HLA-DQA2
    Tuberculosis IL12B; AKT2; TLR9; TLR4; HLA-DPB1; STAT1; PMAP-36; RAB7A; CAMK2G; FCGR1A
    Influenza A IRF3; PIK3CA; MAP2K4; MAP2K6; PIK3R2; PABPN1L; Ifna15; NFKB1; LOC100686744; KPNA2
    HTLV-I infection MAP2K4; MAP3K1; VDAC2; APC2; FZD5; TGFB1; SRF; RRAS; SMAD4; TBPL1
    Herpes simplex infection NFKBIB; TP53; TNFSF14; IFNG1-2; BLB1; ARNTL; IL12B; IRF3; TAF6L; SRSF1
    Epstein-Barr virus infection YWHAE; HLA-DRB4; HSPA6; POLR2D; NCOR2; SPI1; PSMD11; IKBKG; RBPJL; GTF2B
    Asthma HLA-DQA2; CD40; IL13; IL5; IL4; HLA-DMB; HLA-DMA; HLA-DPB1; HLA-DRB3; CD40LG
    Autoi HLA-DQA1; HLA-DRB3; HLA-DQB1; Fasl; HLA-DQA2; CD40; IFNA13; PRF1; FAS; HLA-A
    ne thyroid disease CD86; HLA-DPB1; IFNA7; H2-Q10; IFNA12; PRF1; HLA-DQB1; IFNA16; IFNA4; IL5
    Inflammatory bowel disease (IBD) HLA-DQA1; IL5; IL4R; IL1B; HLA-DMB; RORA; IL17F; HLA-DMA; Il2; NFKB1
    Systemic lupus erythematosus GRIN2B; ACTN4; HLA-DMA; SNRPD3; TRIM21; HIST2H4A; HIST1H2AC; HIST1H3F; ACTN3; HIST1H2AN
    Rheumatoid arthritis Il23a; Il12b; CXCL12; TEK; CD86; H2-AB1; ATP6V0C; IL6; TGFB2; HLA-DMB; ATP6V1F
    Allograft rejection HLA-A; PRF1; HLA-DQB1; HLA-DRA; HLA-DRB3; TNF; Fasl; HLA-DMA; HLA-F; H2-AA
    Graft-versus-host disease Fasl; CD80; TNF; IFNG; KIR3DL2; HLA-DMA; Il2; CD28; KIR2DL3; KIR2DL1
    Viral myocarditis HLA-G; CCND1; EIF4G2; ITGB2; FYN; CD28; RAC2; ICAM1; HLA-DRB4; CD40

    hla-dpb1 has several biochemical functions, for example, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hla-dpb1 itself. We selected most functions hla-dpb1 had, and list some proteins which have the same functions with hla-dpb1. You can find most of the proteins on our site.

    Function Related Protein
    peptide antigen binding MAML1; HLA-C; HLA-B; MHC1UIA; MHC1UXA2; MHC1UFA; HLA-DQB1; MR1; MHC1ZDA; CLEC4M

    hla-dpb1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hla-dpb1 here. Most of them are supplied by our site. Hope this information will be useful for your research of hla-dpb1.

    COPB1; recB; manX; pyc; sbcD; hppD; arnA; ROBO2; RTN4

    Lambert, ND; Haralambieva, IH; et al. Polymorphisms in HLA-DPB1 Are Associated With Differences in Rubella Virus-Specific Humoral Immunity After Vaccination. JOURNAL OF INFECTIOUS DISEASES 211:898-905(2015).
    Baldwin, KM; Ehrenberg, PK; et al. HLA class II diversity in HIV-1 uninfected individuals from the placebo arm of the RV144 Thai vaccine efficacy trial. TISSUE ANTIGENS 85:117-126(2015).

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