HLA-DPB1 Protein


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Official Full Name major histocompatibility complex, class II, DP beta 1
Background HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Synonyms HLA-DPB1; major histocompatibility complex, class II, DP beta 1; HLA DP1B; HLA class II histocompatibility antigen, DP beta 1 chain; MHC HLA DPB1; HLA DP14-beta chain; MHC class II HLA-DRB1; class II HLA beta chain; MHC class II HLA-DP-beta; MHC class II
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DPB1-1278H Recombinant Human HLA-DPB1 Protein (30-223 aa), His-tagged E.coli His
    Human HLA-DPB1-30198TH Recombinant Human HLA-DPB1 Wheat Germ N/A
    Human HLA-DPB1-4841H Recombinant Human HLA-DPB1 Protein, GST-tagged Wheat Germ GST
    Human HLA-DPB1-5505HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    HLA-DPB1 involved in several pathways and played different roles in them. We selected most pathways HLA-DPB1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DPB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome HLA-DPA1; DYNC1I1; HLA-C; HLA-DQA1; RAB7; ITGB5; CALR; C3A.1; DYNC1I2A; ATPV0E2
    Cell adhesion molecules (CAMs) NLGN3A; CNTN1A; SELP; NRXN1A; CLDN10; HLA-DPA1; GLG1; HLA-DOA; ITGAM; VTCN1
    Antigen processing and presentation KIR2DL4; CD8B1; KIR3DL2; CD74; RFXANK; PDIA3; NFYA; HLA-DOA; KIR2DS2; PSME2
    Intestinal i HLA-DQB1; CCR9A; BLA; H2-AA; IL6; CD40; MAP3K14; HLA-DRB4; CXCR4A; IL5
    ne network for IgA production CXCR4; TNFSF13; CCR9A; CXCL12; PIGR; BLB2; HLA-DMA; CXCL12A; HLA-DRA; HLA-DQA2
    Type I diabetes mellitus HLA-DRB3; ICA1; IFNG; HLA-DQB1; IL1B; HLA-DRA; HLA-DQA1; PRF1; Il2; HLA-DOB
    Toxoplasmosis CD40; H2-AB1; HSPA1A; IL10RB; MAP3K7; HLA-DRB3; HSPA1L; MYD88; LAMA3; HLA-DPB1
    Staphylococcus aureus infection HLA-DRB5; CFI; C4A; FGG; FPR3; MBL2; SELP; HLA-DRB3; HLA-DQB1; ICAM1
    Tuberculosis CAP18; MAPK13; RAB7A; IRAK2; BAX; IFNA12; CLEC4E; PPP3R2; HLA-DMA; AKT2
    HTLV-I infection TGFB2; FZD10; APC; ATF4; TCF3; RB1; LTA; ANAPC7; CCNB2; CRTC2
    Herpes simplex infection MAPK8A; C3A.2; SRSF5A; HLA-DRB3; HLA-C; SRSF7B; CYCS; PILRA; PER1A; TAF4B
    Epstein-Barr virus infection MAP2K3; IKBKG; TAB2; MAP2K4; POLR2L; PSMC4; POLR1D; PSMD3; HLA-DPA1; CD58
    Autoi H2-AB1; HLA-DOA; FAS; FASLG; Ifna15; HLA-DRB4; HLA-C; HLA-DRB1; IFNA21; PRF1
    ne thyroid disease IFNA8; IL4; H2-AB1; HLA-DQA2; IFNA4; IFNA2; TG; IFNA13; CD40LG; HLA-DOB
    Inflammatory bowel disease (IBD) TNF; Il2; IL5; TLR5; IL12A; IL17F; IL1A; RORC; HLA-DOB; RORA
    Systemic lupus erythematosus CD80; HIST1H4H; HIST1H4E; IFNG; HIST1H4N; HIST1H2AP; SNRPD1; H2-AB1; HIST1H2AL; HIST1H3D
    Rheumatoid arthritis CD86; IL18; HLA-DMB; ANGPT1; HLA-DQA2; Ctsl; IL11; ATP6V1F; IFNG; H2-AB1
    Allograft rejection IL10; HLA-DPA1; HLA-DQB1; CD28; FAS; TNF; Fasl; IFNG; HLA-F; HLA-DMB
    Graft-versus-host disease CD80; HLA-DOA; HLA-DRB1; HLA-DQB1; HLA-G; HLA-A; HLA-DRB4; H2-AA; KIR2DL3; HLA-C
    Viral myocarditis HLA-E; HLA-F; SGCB; BID; CCND1; CD80; SGCG; ICAM1; HLA-DRA; HLA-C

    HLA-DPB1 has several biochemical functions, for example, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DPB1 itself. We selected most functions HLA-DPB1 had, and list some proteins which have the same functions with HLA-DPB1. You can find most of the proteins on our site.

    Function Related Protein
    peptide antigen binding CLEC4M; MHC1UFA; H2-Q10; AZGP1; H2-AB1; HLA-DQB1; MAML1; HLA-DRB4; MHC1UJA; MHC1ZHA

    HLA-DPB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DPB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DPB1.

    COPB1; recB; manX; pyc; sbcD; hppD; arnA; ROBO2; RTN4

    Lambert, ND; Haralambieva, IH; et al. Polymorphisms in HLA-DPB1 Are Associated With Differences in Rubella Virus-Specific Humoral Immunity After Vaccination. JOURNAL OF INFECTIOUS DISEASES 211:898-905(2015).
    Baldwin, KM; Ehrenberg, PK; et al. HLA class II diversity in HIV-1 uninfected individuals from the placebo arm of the RV144 Thai vaccine efficacy trial. TISSUE ANTIGENS 85:117-126(2015).

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