HLA-DQB1 Protein


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Official Full Name major histocompatibility complex, class II, DQ beta 1
Background HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 (later DQ1, and split into DQ5 and DQ6), DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ alpha (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.
Synonyms CELIAC1; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA DQB; HLA DQB1; IDDM1; Lymphocyte antigen; Major histocompatibility complex class II beta; Major histocompatibility complex, class II, DQ beta 1; MHC class II antigen DQB1; MHC class II antigen HLA DQ beta 1; MHC class II DQ beta chain; MHC class II HLA DQ beta glycoprotein; MHC class2 antigen; MHC DQ beta; OTTHUMP00000029167; OTTHUMP00000178569; OTTHUMP00000178570; OTTHUMP00000178571; HLA-DQB1; DQw1
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DQB1-12H Recombinant Human HLA-DQB1 protein, GST-tagged Wheat Germ GST
    Human HLA-DQB1-802H Recombinant Human HLA-DQB1 protein, GST-tagged Wheat Germ GST
    Human HLA-DQB1-4097H Recombinant Human HLA-DQB1 protein, His-tagged E.coli His
    Human HLA-DQB1-27714TH Recombinant Human HLA-DQB1 Wheat Germ N/A
    Human HLA-DQB1-5496HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    HLA-DQB1 involved in several pathways and played different roles in them. We selected most pathways HLA-DQB1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome Cd209g; ATP6V1D; TUBB5; BLB2; FAM49BA; CD36; ATP6V1H; BLA; SCARB1; ATP6V1B2
    Cell adhesion molecules (CAMs) HLA-DRA; NRXN1; NADL1.2; NLGN2B; NLGN1; SDC1; CLDN18; ESAM; JAM3B; GLYCAM1
    Antigen processing and presentation TAP1; NFYA; KIR2DL3; TAP2; Ctsl; CD8A; CD8B1; HLA-DPB1; TNF; HLA-DOB
    Intestinal i HLA-DOA; H2-AA; CCL25; HLA-DRB3; MHC2A; BMA2; ITGB7; HLA-DMB; TGFB1A; CD40LG
    ne network for IgA production CD28; CXCR4A; CCL28; TNFSF13; ITGB7; IL15RA; TNFRSF17; CCL27B; BLA; HLA-DMA
    Type I diabetes mellitus IL12B; HLA-DOA; HLA-G; HLA-DRB4; GZMB; HLA-DQA1; IL12A; HLA-C; INS; H2-AA
    Leishmaniasis MYD88; NCF1; FCGR3; MAPK13; HLA-DPA1; TAB2; FCGR3A; TGFB1; STAT1; CR1
    Toxoplasmosis HLA-DPB1; LAMB3; MAP3K7; H2-AA; TGFB2; BCL2; MAPK3; MAPK9; BIRC8; RELA
    Staphylococcus aureus infection C1S; Hc; DSG1C; C1R; FCGR3A; cgr2b; HLA-DOA; FCGR1A; C1QC; ITGAM
    Tuberculosis ATP6AP1; CASP10; MAPK10; FCGR2A; IFNA10; Il23a; Il12b; RAB5C; IL12B; HLA-DQA2; PPP3CC
    Influenza A NLRP3; IFNA10; HSPA6; TLR7; TNFRSF10D; ACTB; NXT2; LOC100686744; IFNG; TNFRSF10C
    Herpes simplex infection PER1B; CD74; BLA; C3; DAXX; HNRPKL; PILRA; NXF3; IFNA12; IFNA13
    Epstein-Barr virus infection POLR2D; RB1; HSPA1B; POLR2J3; PIK3R1; POLR1D; SPN; PRKACG; POLR3H; GTF2B
    Autoi IFNA1; TSHR; Fasl; IFNA6; HLA-E; HLA-F; IFNA2; CD40; HLA-DRB3; HLA-DMA
    ne thyroid disease IFNA13; HLA-DRA; CD40; CD86; FAS; HLA-DPA1; Ifna15; TSHR; TPO; HLA-DMB
    Inflammatory bowel disease (IBD) HLA-DQA1; HLA-DRB1; IL23R; TLR5; TGFB1; IL17A; TGFB2; HLA-DPB1; IL1B; TNF
    Systemic lupus erythematosus HIST1H2AO; FCGR3; HIST1H2BH; FCGR4; FCGR1A; H3F3B; HIST1H2BE; ACTN2; HLA-DRB4; HIST1H2BG
    Rheumatoid arthritis HLA-DQA1; ATP6V1E2; HLA-DRB3; CCL2; TGFB2; CXCL6; TLR2; ATP6V0D2; ATP6V1C2; H2-AA
    Allograft rejection HLA-DQA1; TNF; GZMB; H2-Q10; IL5; HLA-DPA1; CD28; CD40; Fasl; HLA-E
    Graft-versus-host disease HLA-B; CD80; HLA-DRA; FASLG; HLA-DOB; HLA-F; TNF; KLRC1; IL1B; HLA-DQA1
    Viral myocarditis CD40; LAMA2; ABL1; CD86; HLA-DRB3; HLA-DPB1; ICAM1; ABL2; HLA-DMB; H2-Q10

    HLA-DQB1 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQB1 itself. We selected most functions HLA-DQB1 had, and list some proteins which have the same functions with HLA-DQB1. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II receptor activity KRT17; HLA-DOA; HLA-DPA1; HLA-DRA; HLA-DQA1; HLA-DQA2; HLA-DOB; HLA-DQB1; HLA-DRB3; HLA-DRB4
    peptide antigen binding HLA-DRB4; MHC1ZHA; MHC1UDA; TAPBP; MHC1UBA; CD209; MHC1ZKA; HLA-DRA; TAP1; MHC1UXA2

    HLA-DQB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQB1.


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