HLA-DQB1

  • Official Full Name

    major histocompatibility complex, class II, DQ beta 1

  • Overview

    HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 (later DQ1, and split into DQ5 and DQ6), DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ alpha (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.

  • Synonyms

    CELIAC1;HLA class II histocompatibility antigen, DQ beta 1 chain;HLA DQB;HLA DQB1;IDDM1;Lymphocyte antigen;Major histocompatibility complex class II beta;Major histocompatibility complex, class II, DQ beta 1;MHC class II antigen DQB1;MHC class II antigen HLA DQ beta 1;MHC class II DQ beta chain;MHC class II HLA DQ beta glycoprotein;MHC class2 antigen;MHC DQ beta;OTTHUMP00000029167;OTTHUMP00000178569;OTTHUMP00000178570;OTTHUMP00000178571;HLA-DQB1;DQw1

Recombinant Proteins

  • Human
  • Wheat Germ
  • HEK293
  • E.coli
  • In Vitro Cell Free System
  • GST
  • Non
  • His
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-DQB1-12H Recombinant Human HLA-DQB1 protein, GST-tagged Wheat Germ Human GST 1-261 a.a.
HLA-DQB1-27714TH Recombinant Human HLA-DQB1 Wheat Germ Human Non 89 amino acids
HLA-DQB1-802H Recombinant Human HLA-DQB1 protein, GST-tagged Wheat Germ Human GST 1-261 a.a.
HLA-DQB1-5496HCL Recombinant Human HLA 293 Cell Lysate HEK293 Human Non
HLA-DQB1-4097H Recombinant Human HLA-DQB1 protein, His-tagged E.coli Human His 33-227aa
HLA-DQB1-673HF Recombinant Full Length Human HLA-DQB1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 261 amino acids
HLA-DQB1-683HF Recombinant Full Length Human HLA-DQB1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 261 amino acids

    Involved Pathway

    HLA-DQB1 involved in several pathways and played different roles in them. We selected most pathways HLA-DQB1 participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Systemic lupus erythematosus HIST1H2BB,GRIN2A,HIST1H4G,HIST1H4M,HLA-DRB1,HIST2H2AA4,HLA-DMA,H2AFJ,HIST1H3F,HIST1H2AC
    Rheumatoid arthritis TNFSF13,HLA-DMB,FOS,ATP6V1E2,CCL3L1,ATP6V0B,ATP6V1G2,ATP6V1C1,ATP6V1G1,ATP6V0D2
    Cell adhesion molecules (CAMs) ITGB1,CLDNC,NLGN2B,HLA-DRB3,CLDN19,CLDNK,HLA-DMA,SELE,CD99,SELP
    Phagosome ATP6V1BA,MHC2DCB,CTSSB.2,SFTPD,STX12,SCARB1,ITGA2,THBS1,MRC1,BF1
    Tuberculosis CD209A,SRC,TLR9,PPP3CB,HLA-DRB5,ATP6V0B,HSPD1,CAMK2A,MAPK9,CD209B
    Antigen processing and presentation CANX,KIR2DS2,HSPA2,KIR2DS3,TNF,CTSS,KIR3DL2,RFX5,HLA-DRB1,HLA-DMA
    Staphylococcus aureus infection HLA-DRB1,GM5077,FPR3,FPR1,HLA-DRB3,ITGAL,HLA-DRA,C4A,DSG1C,HLA-DRB5
    Herpes simplex infection POLR2A,NFKB1,ARNTL1B,PTPN11B,IFNA5,PPP1CB,SRSF7A,IFNB,MHC2DEB,NXF3
    Inflammatory bowel disease (IBD) NFKB1,IL4R,TGFB2,HLA-DRB3,FOXP3,STAT3,HLA-DRB5,SMAD2,TLR4,IFNGR1

    Protein Function

    HLA-DQB1 has several biochemical functions, for example, MHC class II receptor activity,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQB1 itself. We selected most functions HLA-DQB1 had, and list some proteins which have the same functions with HLA-DQB1. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II receptor activity HLA-DPA1,HLA-DRB3,HLA-DOB,HLA-DQB2,HLA-DQA1,HLA-DQA2,HLA-DRB1,HLA-DRB4,KRT17,HLA-DOA
    peptide antigen binding HLA-DRB3,HLA-E,MHC1UBA,MHC1ZFA,MAML1,MHC1UKA,MHC1UEA,MHC1UHA,MHC1ZE,MHC1UJA

    Interacting Protein

    HLA-DQB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQB1.

    HLA-DQA1

    Resources

    Gene Families

    What is immunoglobulin superfamily (IgSF)

    References

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