hla-dra

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hla-dra

Official Full Name major histocompatibility complex, class II, DR alpha
Background HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Synonyms MLRW; FLJ51114; HLA-DRA1; HLA-DRA; HLA class II histocompatibility antigen, DR alpha chain; OTTHUMP00000029406; OTTHUMP00000029407; MHC class II antigen DRA; MHC cell surface glycoprotein; histocompatibility antigen HLA-DR alpha; RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha; ENSOCUG00000009103; chromosome: 12
    • Species :
    • Human
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Yeast
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DRA-231H Recombinant Human HLA-DRA protein, GST-tagged E. coli GST
    Human HLA-DRA-2300H Recombinant Human HLA-DRA Protein (26-254 aa), His-tagged Yeast His
    Human HLA-DRA-353H Recombinant Human HLA-DRA Protein, His-tagged E.coli His
    Human HLA-DRA-490H Recombinant Human major histocompatibility complex, class II, DR alpha, His-tagged E.coli His
    Human HLA-DRA-5501HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    hla-dra involved in several pathways and played different roles in them. We selected most pathways hla-dra participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with hla-dra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome FCAR; TUBA3A; C1R; TUBB2; ATP6V1E2; FCGR1; TUBA3D; HLA-DMA; DYNC2H1; HLA-F
    Cell adhesion molecules (CAMs) CLDN11B; NEO1; HLA-DMB; SDC4; ICAM1; HLA-DPA1; CD8B1; MPZ; CD34; HLA-DRB3
    Antigen processing and presentation RFX5; KIR3DL1; KIR2DL1; KIR2DS3; CD8B; RFXAP; H2-AB1; CD8A; HLA-DQB1; NFYB
    Hematopoietic cell lineage Cd24a; CD5; IL11; CR1; IL1A; CD9; CD34; FLT3LG; FCGR1A; CD44
    Intestinal i HLA-DPA1; H2-AA; HLA-DRB4; BMA1; CD86; HLA-DQA1; MAP3K14; LTBR; TGFB1; ICOSLG
    ne network for IgA production MHC2DCB; ITGA4; HLA-DMB; H2-AB1; TGFB1; BMA1; Icosl; CXCR4A; HLA-DRB4; BMA2
    Type I diabetes mellitus HLA-DPB1; CD80; HLA-G; HLA-C; INS2; CD28; LTA; HLA-B; HSPD1; HLA-DRB5
    Leishmaniasis IL1B; FCGR3B; NCF1; FCGR1A; HLA-DQA2; NOS2; FCGR2C; HLA-DPA1; MARCKSL1; IL1A
    Toxoplasmosis GNAI3; TYK2; IRGM; IKBKG; Toxoplasma Gondii Major Surface Antigen P30; NFKBIB; TAB2; ITGB1; H2-AA; MAPK12
    Staphylococcus aureus infection HLA-DRB5; HLA-DPA1; C3AR1; H2-AB1; HLA-DQA1; FCGR2C; MBL1; FCAR; FCGR3B; C3
    Tuberculosis IRAK4; Ifna11; ARHGEF12; IL6; MAPK9; RFX5; CLEC4E; LSP1; MAPK12; PLK3
    Influenza A VDAC1; NLRP3; IL1A; H2-AB1; IFNA12; MAPK13; TNFRSF10A; PIK3R3; PABPN1; PIK3R5
    HTLV-I infection IL1R2; BUB1B; TERT; NFKB2; KRAS; MAP3K1; WNT5A; MSX1; HLA-DQA2; HLA-DPB1
    Herpes simplex infection IFNB1; IFNG; HLA-A; IFNA2; IFIH1; NFKBIAA; CDK1; SRSF6B; PVRL1; PER3
    Epstein-Barr virus infection TAB2; HDAC4; MAPK8; PLCG2; CDK1; GSK3B; ICAM1; TYK2; POLR2I; PSMC2
    Asthma HLA-DRB3; MS4A2; HLA-DQA2; HLA-DOA; PRG2; HLA-DRB5; HLA-DMA; FCER1G; HLA-DMB; IL9
    Autoi HLA-DPB1; TSHR; GZMB; IFNA1; IFNA17; IFNA8; HLA-C; TPO; HLA-DMA; HLA-DRB5
    ne thyroid disease HLA-DOB; HLA-DPB1; IFNA14; HLA-C; HLA-DQA1; TSHR; HLA-B; Ifna15; HLA-A; GZMB
    Inflammatory bowel disease (IBD) HLA-DPA1; IL21R; TGFB3; RORC; TNF; IL1B; IL12RB2; IL5; IL4; NFKB1
    Systemic lupus erythematosus IFNG; HIST1H2BH; HIST1H3I; HIST1H2BO; FCGR1; GM14482; C1RA; HLA-DQA1; GM14477; CD28
    Rheumatoid arthritis CCL20; TNFRSF11A; ATP6V0E; HLA-DOA; ATP6V1E1; ACP5; ATP6V0E2; LTB; TNFSF13; CCL3L3
    Allograft rejection FASLG; HLA-DQA1; CD40; HLA-DQB1; TNF; HLA-DPA1; Il2; CD40LG; IL10; HLA-E
    Graft-versus-host disease PRF1; H2-Q10; H2-AA; HLA-DMA; TNF; HLA-DPB1; HLA-DQB1; Il2; HLA-DPA1; CD28
    Viral myocarditis SGCB; HLA-A; HLA-DQA1; RAC2; CYCS; ACTG1; HLA-B; EIF4G2; CAV1; EIF4G3

    hla-dra has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hla-dra itself. We selected most functions hla-dra had, and list some proteins which have the same functions with hla-dra. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein complex binding ANXA11; HSP90AB1; PKM2; MS4A1; HSP90AA1; CD81; HLA-DRB1; CD74; HLA-DMA; HLA-DMB
    MHC class II receptor activity HLA-DQB1; HLA-DOA; HLA-DQA2; HLA-DOB; HLA-DRB1; HLA-DRB3; KRT17; HLA-DRA; HLA-DRB4; HLA-DQB2
    peptide antigen binding MR1; MHC1UBA; HLA-B; HLA-C; HLA-F; HLA-A; TUBB3; BF2; MHC1UHA; HLA-DPA1

    hla-dra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hla-dra here. Most of them are supplied by our site. Hope this information will be useful for your research of hla-dra.

    HLA-DRB1; HLA-DRB1; HLA-DMA

    Tu, WL; Liu, YQ; et al. Genome-Wide Loci Linked to Non-Obstructive Azoospermia Susceptibility May Be Independent of Reduced Sperm Production in Males with Normozoospermia. BIOLOGY OF REPRODUCTION 92:-(2015).
    Gan, SJ; Ye, B; et al. Immune- and Ribosome-Related Genes were Associated with Systemic Vasculitis. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:96-101(2015).

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