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hly

  • Overview

    The secreted pore-forming protein listeriolysin O (LLO) is an essential virulence determinant of the facultative intracellular bacterium Listeria monocytogenes that allows the pathogen to escape from the phagocytic vacuole and reach the host cytosol. LLO is a single polypeptide protein encoded by the hlyA gene and composed of 529 residues. At its NH2-terminus it possesses a 25 residues long typical signal sequence excited during the secretion process. Moreover, in its NH2-terminus there is also a 19 amino acids PEST- like sequence that may target this toxin for degradation. This motif seems to be essential for bacterial virulence too, since its deletion causes a defect in bacterium phagosomal escaping.
  • Synonyms

    Hly;listeriolysin O;identified by similarity to SP:P13128;match to protein family HMM PF01289;

  • Recombinant Proteins
  • Listeria monocytogenes
  • Listeria monocytogenes serotype 1/2a (strain 08-5923)
  • S. alpha
  • Staphylococcus Aureus
  • E.coli
  • Yeast
  • C
  • His
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Listeria monocytogenes hly-241 Active Recombinant Listeria monocytogenes hly protein E.coli N/A
Listeria monocytogenes hly-5586L Recombinant Listeria monocytogenes hly Protein (Asp26-Glu529), C-His tagged E.coli C-His Asp26-Glu529
Listeria monocytogenes serotype 1/2a (strain 08-5923) hly-5680L Recombinant Listeria monocytogenes serotype 1/2a hly Protein (Asp26-Glu529), C-His tagged E.coli C-His Asp26-Glu529
S. alpha HLY-01S Recombinant Active S. alpha HLY protein E.coli
Staphylococcus Aureus HLY-1666S Recombinant Staphylococcus Aureus HLY Protein (27-319 aa), His-tagged Yeast His 27-319 aa
Staphylococcus Aureus HLY-1020S Recombinant Staphylococcus Aureus HLY Protein (27-319 aa), His-SUMO-tagged E.coli His/SUMO 27-319 aa
hly-243 Active Recombinant Listeriolysin O, PEST Free E.coli N/A
  • Q&As
  • Reviews

Q&As (5)

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What other medical conditions can benefit from HLY protein-based drug delivery? 02/25/2021

HLY protein can be used in various diseases, including infectious diseases, genetic disorders, and neurological conditions.

Can HLY protein be used in cancer treatment? 12/15/2019

Yes, it can be used to deliver chemotherapy drugs directly to cancer cells.

Can HLY protein be used for diagnostics? 11/16/2017

Yes, it can be used in diagnostic assays to detect specific cells or molecules in clinical samples.

How does HLY protein assist in drug delivery? 10/29/2016

HLY protein can be engineered to create pores in the membranes of specific cells, allowing drugs to enter these cells more effectively.

How can HLY protein be used in clinical applications? 05/16/2016

HLY protein has several clinical applications due to its ability to create pores in cell membranes.

Customer Reviews (3)

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Reviews
03/21/2018

    Whether it's modifying protocols, providing custom formulations, or offering personalized recommendations, their flexibility ensures that I have the necessary tools to carry out my experiments seamlessly.

    01/17/2018

      The combination of exceptional quality, reliable performance, and dedicated customer service makes them an invaluable partner in my research journey.

      12/02/2016

        Their proactive approach ensures that I am always working with the latest advancements in HLY protein research, allowing me to explore new avenues and potentially uncover groundbreaking discoveries.

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