hrg
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  • Official Full Name
  • histidine-rich glycoprotein
  • Background
  • This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit roset
  • Synonyms
  • HRG; histidine-rich glycoprotein; DKFZp779H1622; Histidine proline rich glycoprotein; Histidine rich glycoprotein; HPRG; HRGP; Thrombophilia due to elevated HRG; OTTMUSP00000045931; histidine-proline-rich glycoprotein; D16jh2; D18020; AI265597; AW413091; THPH11
Cat.#:HRG-425RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat HRG Protein, His-tagged
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Cat.#:HRG-2133HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HRG Protein, MYC/DDK-tagged
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Cat.#:HRG-5032HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HRG Protein, GST-tagged
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Cat.#:HRG-332HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Histidine-Rich Glycoprotein
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Cat.#:HRG-514HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human HRG protein, His-tagged
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Cat.#:HRG-593HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human HRG protein, His-tagged
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Cat.#:HRG-753HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human HRG, His tagged
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Cat.#:HRG-7862HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HRG protein, His & GST-tagged
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Cat.#:Hrg-452MTag:His
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Hrg, His-tagged
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Cat.#:HRG-7847MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HRG Protein
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Cat.#:Hrg-7863MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hrg protein, His & GST-tagged
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Cat.#:HRG-2910RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HRG Protein
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Cat.#:Hrg-519RTag:His
Source (Host):HEK293FSpecies:Rat
Product nameRecombinant Rat Hrg protein, His-tagged
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Cat.#:Hrg-7864RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hrg protein, His & T7-tagged
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Cat.#:HRG-2790HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human HRG cell lysate
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Involved Pathway

HRG involved in several pathways and played different roles in them. We selected most pathways HRG participated on our site, such as Dissolution of Fibrin Clot, Hemostasis, Platelet activation, signaling and aggregation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HRG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Dissolution of Fibrin Clot
HRG; SERPINE2; S100A10A; SERPINB8; S100A10; S100A10B; SERPINF2B; ANXA2B; ANXA2; ANXA2A
Hemostasis
DOCK2; S100A10; SCG3; ANXA2B; KIFC1; CD9B; DOCK11; MFN2; IRF2A; KCNMB2
Platelet activation, signaling and aggregation
GNA13B; HRG; RHOGA; GAS6; IGF2B; MMRN1; C6orf25; MMRN2A; AASS; F13A1A.1
Platelet degranulation
F13A1A.1; F13A1B; GAS6; CD9A; WDR1; SCG3; IGF2B; MMRN2A; SERPINF2B; PLEK
Response to elevated platelet cytosolic Ca2+
PLEK; HRG; SPARC; SRGN; MMRN1; IGF2B; F13A1B; CD9A; CAP1; STXBP3A

Protein Function

HRG has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity, heme binding, heparan sulfate proteoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HRG itself. We selected most functions HRG had, and list some proteins which have the same functions with HRG. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase inhibitor activity
Related Protein PTTG1; AHSG1; SERPINB4; CST9; BIRC5B; FETUB; CST2; CST8; CSTA; SPOCK1
Function heme binding
Related Protein CYP4V8; SDHDA; CYP2X9; HBM; CYP4V7; CYP2A7; CYP46A1.2; CYP4F22; CYP2V1; CYP1D1
Function heparan sulfate proteoglycan binding
Related Protein COMP; HRG; SEMA5A; Itgam&Itgb2; AGRN; GPC3; GPC1; GPC5; GPC6A; GPC1A
Function heparin binding
Related Protein COL20A1; PTPRF; ADAMTS3; WISP1A; PTPRFB; FGF2; RPL29; COL13A1; LIPG; THBS3
Function immunoglobulin binding
Related Protein VWF; HRG; cgr2b
Function metal ion binding
Related Protein PPP1CB; ZFP36L3; BMPR1BA; S100T; LIG1; SETDB1A; ZSCAN4F; RORAB; ZNF317; GUCA1D
Function protein binding
Related Protein ATP6V1B2; PPP2R2C; AMDHD2; ARHGAP17; SHC1; PTCRA; DCSTAMP; NUDC; ICK; PTPN1
Function receptor binding
Related Protein FGF11; PGR; CCL15; CX3CL1; NTF7; SMARCD1; HCK; NRG4; PTK2B; Icosl
Function serine-type endopeptidase inhibitor activity
Related Protein SERPINI1; SERPINA6; PCSK1NL; WFDC5; HRG; SERPINB2; TFPIA; SERPINC1; TFPI2; SPINK13
Function zinc ion binding
Related Protein SKI; CPN1; MSL2A; RABIF; RARG; TAF2; CPD; TOPORS; ZACN; FAM90A1

Interacting Protein

HRG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HRG here. Most of them are supplied by our site. Hope this information will be useful for your research of HRG.
q99xu0_strp1; RCHY1; q99xu0_strp1; PLSCR1; GAMMAHV.ORF4; GAMMAHV.ORF31; SPRY1; FN1; TNFRSF1A; q99ib8-pro_0000045596; CHRD; RABAC1; d-mannose

HRG Related Articles

Hu, S; Dai, HB; et al. Silencing EGFR/HER3 signaling with a novel anti-EGFR domain II/IV antibody. CANCER LETTERS 357:374-383(2015).
Kawakami, H; Okamoto, I; et al. The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells. ONCOTARGET 5:11847-11856(2014).