Hrh2

  • Official Full Name

    histamine receptor H2

  • Overview

    Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    HRH2; histamine receptor H2; histamine H2 receptor; HH2R; gastric receptor 1; gastric receptor I; H2R;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canine
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cavia porcellus (Guinea pig)
  • Gorilla gorilla gorilla (Western lowland gorilla)
  • Guinea Pig
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Pan troglodytes (Chimpanzee)
  • Pongo pygmaeus (Bornean orangutan)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Zebrafish
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag|His
  • His
  • His (Fc)
  • Avi
  • His|Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HRH2-1047H Recombinant Human Histamine Receptor H 2 Sf9 Insect Cell N/A
Human HRH2-27612TH Recombinant Human HRH2 Flag/His
Human HRH2-5036H Recombinant Human HRH2 Protein Wheat Germ N/A
Human HRH2-3666HF Recombinant Full Length Human HRH2 Protein In Vitro Cell Free System 218 amino acids
Rat Hrh2-788R Recombinant Rat Hrh2 Protein Insect Cell N/A
Rat HRH2-2912R Recombinant Rat HRH2 Protein Mammalian Cell His
Rat HRH2-2567R-B Recombinant Rat HRH2 Protein Pre-coupled Magnetic Beads HEK293
Rat HRH2-2567R Recombinant Rat HRH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canine HRH2-783C Recombinant Canine HRH2 Protein, His/FLAG-tagged Insect Cell His/Flag
Canis lupus familiaris (Dog) (Canis familiaris) RFL13399CF Recombinant Full Length Dog Histamine H2 Receptor(Hrh2) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Cavia porcellus (Guinea pig) RFL23220CF Recombinant Full Length Guinea Pig Histamine H2 Receptor(Hrh2) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Gorilla gorilla gorilla (Western lowland gorilla) RFL35297GF Recombinant Full Length Gorilla Gorilla Gorilla Histamine H2 Receptor(Hrh2) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Guinea Pig Hrh2-1043G Recombinant Guinea Pig Histamine Receptor H 2 Sf9 Insect Cell N/A
Homo sapiens (Human) RFL32241HF Recombinant Full Length Human Histamine H2 Receptor(Hrh2) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Mus musculus (Mouse) RFL18362MF Recombinant Full Length Mouse Histamine H2 Receptor(Hrh2) Protein, His-Tagged E.coli expression system His Full Length (1-358)
Pan troglodytes (Chimpanzee) RFL14624PF Recombinant Full Length Pan Troglodytes Histamine H2 Receptor(Hrh2) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Pongo pygmaeus (Bornean orangutan) RFL31377PF Recombinant Full Length Pongo Pygmaeus Histamine H2 Receptor(Hrh2) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Rattus norvegicus (Rat) RFL19947RF Recombinant Full Length Rat Histamine H2 Receptor(Hrh2) Protein, His-Tagged E.coli expression system His Full Length (1-358)
Rhesus Macaque HRH2-2143R Recombinant Rhesus monkey HRH2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HRH2-1964R-B Recombinant Rhesus Macaque HRH2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HRH2-1964R Recombinant Rhesus Macaque HRH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HRH2-4320Z Recombinant Zebrafish HRH2 Mammalian Cell His
Kit-0882 Potassium Assay Kit N/A
Hrh2-1143R Hrh2; Histamine receptor H 2; H2R; Histamine H2 receptor Sf9 Insect Cell N/A
Kit-1345 cAMP HRH2 CHO-K1 GPCR Assay Kit N/A
Kit-1030 Phospho-p53 (Ser15) Translocation Assay Kit (Cell-Based) N/A
Kit-1344 HRH2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Hrh2 involved in several pathways and played different roles in them. We selected most pathways Hrh2 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hrh2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayCACNA1H;CHRM5;TNNC2;EGFRA;ERBB3A;RYR1;TACR1B;CYSLTR1;ADORA2A
Neuroactive ligand-receptor interactionGh;P2RX3;FPR1;TACR3L;TAAR13C;CHRNA6;ADRB3B;GRPR;PRL2
Gastric acid secretionKCNK10;PRKCA;PRKACB;GNAI1;PLCB2;CAMK2B;Car2;GNAI2;GAST

Hrh2 has several biochemical functions, for example, NOT dopamine binding, NOT dopamine neurotransmitter receptor activity, coupled via Gs, histamine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Hrh2 itself. We selected most functions Hrh2 had, and list some proteins which have the same functions with Hrh2. You can find most of the proteins on our site.

Function Related Protein
NOT dopamine binding
NOT dopamine neurotransmitter receptor activity, coupled via Gs
histamine receptor activityHRH2;HTR6;HRH4;HRH3;HRH1

Hrh2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hrh2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Hrh2.

cimetidine; aminopotentidine

Gene Family

GPCRs

Research Area

Related articles

Toubanaki, DK; Christopoulos, TK; et al. High-throughput chemiluminometric genotyping of single nucleotide polymorphisms of histamine, serotonin, and adrenergic receptor genes. ANALYTICAL BIOCHEMISTRY 385:34-41(2009).
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