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Official Full Name histamine receptor H2
Background Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms HRH2; histamine receptor H2; histamine H2 receptor; HH2R; gastric receptor 1; gastric receptor I; H2R
    • Species :
    • Canine
    • Guinea Pig
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HRH2-1047H Recombinant Human Histamine Receptor H 2 Sf9 Insect Cell N/A
    Human HRH2-27612TH Recombinant Human HRH2 Flag/His
    Human HRH2-5036H Recombinant Human HRH2 Protein Wheat Germ N/A
    Rat HRH2-2912R Recombinant Rat HRH2 Protein Mammalian Cell His
    Rat Hrh2-788R Recombinant Rat Hrh2 Protein Insect Cell N/A
    Rhesus Macaque HRH2-2143R Recombinant Rhesus monkey HRH2 Protein, His-tagged Mammalian Cell His
    Canine HRH2-783C Recombinant Canine HRH2 Protein, His/FLAG-tagged Insect Cell His/Flag
    Zebrafish HRH2-4320Z Recombinant Zebrafish HRH2 Mammalian Cell His
    Guinea Pig Hrh2-1043G Recombinant Guinea Pig Histamine Receptor H 2 Sf9 Insect Cell N/A
    Hrh2-1143R Hrh2; Histamine receptor H 2; H2R; Histamine H2 receptor Sf9 Insect Cell N/A
    Kit-0882 Potassium Assay Kit N/A
    Kit-1030 Phospho-p53 (Ser15) Translocation Assay Kit (Cell-Based) N/A
    Kit-1344 HRH2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
    Kit-1345 cAMP HRH2 CHO-K1 GPCR Assay Kit N/A

    Hrh2 involved in several pathways and played different roles in them. We selected most pathways Hrh2 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hrh2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway ADCY2B; EDNRB2; PLCB4; PLCZ1; DRD1B; SLC8A1; SLC8A3; PPIFA; PRKACB; PPP3CCA
    Neuroactive ligand-receptor interaction GRPR; PPYR1; NPY7R; GRIK1; GRIK3; GRIA2B; NPY5R; LHBETA1; P2RY14; ADCYAP1R1A
    Gastric acid secretion PLCB2; PLCB1; ATP1A3; SSTR2; GNAI1; ATP1A4; CALM3; PRKACA; CAMK2A; HRH2

    Hrh2 has several biochemical functions, for example, NOT dopamine binding, NOT dopamine neurotransmitter receptor activity, coupled via Gs, histamine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Hrh2 itself. We selected most functions Hrh2 had, and list some proteins which have the same functions with Hrh2. You can find most of the proteins on our site.

    Function Related Protein
    NOT dopamine binding HRH2
    NOT dopamine neurotransmitter receptor activity, coupled via Gs HRH2
    histamine receptor activity HRH2; HRH3; HRH1; HRH4; HTR6

    Hrh2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hrh2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Hrh2.

    cimetidine; aminopotentidine

    Toubanaki, DK; Christopoulos, TK; et al. High-throughput chemiluminometric genotyping of single nucleotide polymorphisms of histamine, serotonin, and adrenergic receptor genes. ANALYTICAL BIOCHEMISTRY 385:34-41(2009).

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