Recombinant Human Histamine Receptor H 2
Cat.No. : | HRH2-1047H |
- Specification
- Gene Information
- Related Products
- Download
Cat. No. : | HRH2-1047H |
Description : | The histamine H2-receptor (H2R) belongs to the superfamily of seven transmembrane domain (7TM), G-protein-coupled receptors (GPCRs). The endogenous agonist for the H2R is histamine which is both neurotransmitter and autacoid.The H2R couples to Gs-proteins to mediate adenylate cyclase (AC) activation. In some systems, the H2R also couples to Gq-proteins and phospholipase C. Among the many responses mediated by the H2R are gastric acid secretion, smooth muscle relaxation, positive ionotropic and chronotropic effects on heart muscle, and inhibition of leukocyte function. The guinea pig H2R (gp H2R) was prepared fromSf9 cellsinfected with gp H2R -encoding baculovirus. In this system, gp H2R couples to the Gs-like G-proteins of the insect cells to mediate AC activation. gp H2R contains a N-terminal FLAG-tag and a Cterminal hexahistidine (His6)-tag for immunological detection, to allow purification, and to provide additional protection against proteolysis. |
Source : | Sf9 insect cells. |
Form : | Membrane suspension. Supplied in 75 mM, Tris-HCl pH 7.4, 12.5 mM MgCl2and 1 mM EDTA. |
Usage : | For in vitro use only. |
Storage : | Quality guaranteed for 12 months. Store at -80°C. Avoid freeze / thaw cycles. |
Tag : | Non |
Gene Name : | HRH2 histamine receptor H 1 [ Cavia porcellus ] |
Synonyms : | HRH2; histamine receptor H 2; Histamine H2 receptor; Gastric receptor I; gastric receptor 1; DBP1; DDX15; DHX15; H2R |
Gene ID : | 3274 |
mRNA Refseq : | NM_001131055 |
Protein Refseq : | NP_001124527 |
MIM : | 142703 |
UniProt ID : | P25021 |
Chromosome Location : | 5q35 |
Pathway : | Calcium signaling pathway; Neuroactive ligand-receptor interaction; Signaling by GPCR |
Function : | G-protein coupled receptor activity; histamine receptor activity; receptor activity |
Products Types
◆ Recombinant Protein | ||
HRH2-2567R | Recombinant Rat HRH2 Protein, His (Fc)-Avi-tagged | +Inquiry |
HRH2-5036H | Recombinant Human HRH2 Protein | +Inquiry |
HRH2-5632W | Recombinant Western lowland gorilla HRH2 protein, His-tagged | +Inquiry |
HRH2-1964R | Recombinant Rhesus Macaque HRH2 Protein, His (Fc)-Avi-tagged | +Inquiry |
HRH2-2143R | Recombinant Rhesus monkey HRH2 Protein, His-tagged | +Inquiry |
◆ Assay kits | ||
Kit-1344 | HRH2 CHO-K1 β-Arrestin GPCR Assay Kit | +Inquiry |
Kit-1345 | cAMP HRH2 CHO-K1 GPCR Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Reviews
- Q&As
Q&As (0)
Ask a questionAsk a Question for All HRH2 Products
Required fields are marked with *
My Review for All HRH2 Products
Required fields are marked with *
0
Inquiry Basket