HSPD1

  • Official Full Name

    heat shock 60kDa protein 1 (chaperonin)
  • Overview

    Heat Shock Protein 60 (HSP60) is a chaperonin with roles in mitochondrial protein import and folding of polypeptides in the mitochondrial matrix.
  • Synonyms

    HSPD1;heat shock 60kDa protein 1 (chaperonin);heat shock 60kD protein 1 (chaperonin) , spastic paraplegia 13 (autosomal dominant) , SPG13;60 kDa heat shock protein, mitochondrial;GROEL;HSP60;chaperonin 60;60 kDa chaperonin;heat shock protein 65

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Rhesus macaque
  • Rat
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • MBP
  • GST
  • T7
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
Hspd1-4058M Recombinant Mouse Hspd1 protein, His-tagged E.coli Mouse His Leu2-Phe573
HSPD1-1555H Active Recombinant Human HSPD1 protein, His-tagged E.coli Human His Full L. 1-573 a.a.
HSPD1-06H Recombinant Human Heat Shock 60kDa Protein 1 (Chaperonin) E.coli Human Non
HSPD1-2131C Recombinant Chicken HSPD1 Mammalian Cells Chicken His
HSPD1-2171R Recombinant Rhesus monkey HSPD1 Protein, His-tagged Mammalian Cells Rhesus macaque His
HSPD1-241H Recombinant Human HSPD1 protein, His-tagged E.coli Human His
Hspd1-242M Recombinant Mouse Hspd1 protein, His-tagged E.coli Mouse His
Hspd1-243R Recombinant Rat Hspd1 protein, His-tagged E.coli Rat His
HSPD1-270H Recombinant Human HSPD1 protein, His/MBP-tagged E.coli Human His&MBP 305-426 aa
HSPD1-2957R Recombinant Rat HSPD1 Protein Mammalian Cells Rat His
HSPD1-326H Recombinant Human Heat Shock 60kDa Protein 1 (Chaperonin), His-tagged; E.coli Human His
HSPD1-4854H Recombinant Human Heat Shock 60kDa Protein 1 (Chaperonin), GST-tagged E.coli Human GST
Hspd1-7778M Recombinant Mouse Hspd1 protein, His & T7-tagged E.coli Mouse His&T7 Met316~Phe573
HSPD1-7923M Recombinant Mouse HSPD1 Protein Mammalian Cells Mouse His
HSPD1-8545H Recombinant Human HSPD1 protein(Leu 2-Phe 573), His&GST-tagged E.coli Human GST&His 2-573 a.a.
HSPD1-9616Z Recombinant Zebrafish HSPD1 Mammalian Cells Zebrafish His
HSPD1-5340HCL Recombinant Human HSPD1 293 Cell Lysate HEK293 Human Non
HSPD1-022H Active Recombinant Human HSPD1 Protein, His-tagged E.coli Human His 2-573
HSPD1-1992R Recombinant Rhesus Macaque HSPD1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
HSPD1-1992R-B Recombinant Rhesus Macaque HSPD1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
HSPD1-2373H Recombinant Human HSPD1 protein(Leu2-Phe573), His&GST-tagged E.coli Human GST&His Leu2-Phe573
HSPD1-2612R Recombinant Rat HSPD1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
HSPD1-2612R-B Recombinant Rat HSPD1 Protein Pre-coupled Magnetic Beads HEK293 Rat
HSPD1-3090H Recombinant Human HSPD1 Protein (Ala27-Phe573), N-His tagged E.coli Human His Ala27-Phe573
HSPD1-4369M Recombinant Mouse HSPD1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
HSPD1-4369M-B Recombinant Mouse HSPD1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
HSPD1-5652HF Recombinant Full Length Human HSPD1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 573 amino acids

    Involved Pathway

    HSPD1 involved in several pathways and played different roles in them. We selected most pathways HSPD1 participated on our site, such as RNA degradation,Type I diabetes mellitus,Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Type I diabetes mellitus INS2,HLA-DPA1,GAD2,CD28,HLA-DRB4,ICA1,CPE,IFNG,FAS,HLA-F
    Legionellosis NAIP7,ITGAM,RELA,HSPA1A,CYCS,Casp3,SEC22B,C3,RAB1B,ITGB2L
    RNA degradation CNOT3,SKIV2L,SMX5,LSM2,HSPA9,DCP1A,DDX6,PABPC1A,CNOT6L,CNOT10
    Tuberculosis CEBPG,CASP8,SRC,HLA-DRA,HLA-DRB5,PPP3CB,CALM3,HLA-DOB,SPHK2,CARD9

    Protein Function

    HSPD1 has several biochemical functions, for example, ATP binding,ATPase activity,DNA replication origin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPD1 itself. We selected most functions HSPD1 had, and list some proteins which have the same functions with HSPD1. You can find most of the proteins on our site.

    Function Related Protein
    protein heterodimerization activity HIST1H2AM,HIST1H3H,ITGB1,TAP1,TRP53,UNC13A,PANX1,UBA3,NEFH,SOX8
    chaperone binding SOD1,VWF,DNAJB7,DNAJC10,DNAJA3A,DNAJB2,Alb,PFDN4,DNAJA3B,DNAJB5
    unfolded protein binding DNAJB11,CCDC102A,HSP90AA1.1,DNAJA3B,DNAJB1,DNAJA1,PDRG1,CCT8,DNAJB1A,CALR
    protease binding SERPINB13,THAP5,RFFL,SERPINB3,KIT,CAST,ADAMTS4,TP53,TIMP1,CFLAR
    insulin binding C2CD2L,IGF1R,IDE,PIK3R1,INSR
    ATP binding DNAH14,CDKL1,CSNK1DA,TRPM6,STRC,STK38A,MYLK,NUBP2,PAK6,ABCD3
    DNA replication origin binding MCM2,ORC2L,ORC3L,CDC45,MCM10,MCM5,ORC4L,ORC4
    double-stranded RNA binding RFTN1,ZFP346,DROSHA,DHX58,ADARB1,HSP90AB1,CLTC,OAS1B,SUPV3L1,RNASEN
    single-stranded DNA binding RAD51B,RPA4,ERCC4,PURB,RPA3,DMC1,PCBP1,RAD51AP1,MCM4,POLR2G

    Interacting Protein

    HSPD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPD1.

    LZTS2;Smpd3;FHIT;RGS20;RGS20

    Resources

    References

    • Hjelholt, A; Carlsen, T; et al. Increased Levels of IgG Antibodies against Human HSP60 in Patients with Spondyloarthritis. PLOS ONE 8:-(2013).
    • Kreutmayer, S; Csordas, A; et al. Chlamydia pneumoniae infection acts as an endothelial stressor with the potential to initiate the earliest heat shock protein 60-dependent inflammatory stage of atherosclerosis. CELL STRESS & CHAPERONES 18:259-268(2013).

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