icam1
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  • Official Full Name
  • intercellular adhesion molecule 1
  • Background
  • This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008] ICAM-1 (55 kDa) is a member of the immunoglobulin supergene family thatfunctions as a ligand for the Lymphocyte Function-Associated Antigen-1. It is asingle-chain glycoprotein that can be expressed on non-hematopoietic cells ofmany lineages. The role of ICAM-1 as a disease marker has been demonstrated fora number of different indications and pathological situations. ICAM-1 upregulation in allergic airway inflammation is responsible for therecruitment of activated leukocytes and the pathogenesis of allergic rhinitis.In lymphoproliferative disorders, ICAM-1 is related to the degree ofmalignancy.
  • Synonyms
  • ICAM1; intercellular adhesion molecule 1; BB2; CD54; P3.58; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; ICAM
Cat.#:ICAM1-1005RTag:His
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus ICAM1 Protein (Met1-Glu480), His-tagged
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Cat.#:ICAM1-22HTag:Fc|His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human ICAM1 Protein, Fc-His-tagged
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Cat.#:ICAM1-799HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICAM1 Protein, MYC/DDK-tagged
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Cat.#:Icam1-4322MTag:N/A
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Icam1 Protein
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Cat.#:ICAM1-4320BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine ICAM1 Protein
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Cat.#:ICAM1-101HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ICAM1, HIgG1 Fc-tagged
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Cat.#:ICAM1-102HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ICAM1, HIgG1 Fc-tagged, mutant
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Cat.#:ICAM1-146HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ICAM1, Fc-tagged
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Cat.#:ICAM1-1625HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human Intercellular Adhesion Molecule 1, Fc Chimera
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Cat.#:ICAM1-2249HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICAM1, His tagged
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Cat.#:ICAM1-2777HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ICAM1 protein, GST-tagged
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Cat.#:ICAM1-278HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Intercellular Adhesion Molecule-1, His-tagged
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Cat.#:ICAM1-28590THTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ICAM1
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Cat.#:ICAM1-28631THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ICAM1, His-tagged
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Cat.#:ICAM1-28924THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ICAM1
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Cat.#:ICAM1-471HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human ICAM1, Fc Chimera
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Cat.#:ICAM1-655HTag:human|IgG1|Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICAM1 protein, Fc-tagged
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Cat.#:ICAM1-656HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICAM1, Fc-His tagged
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Cat.#:ICAM1-657HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICAM1, None tagged
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Cat.#:ICAM1-89HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human ICAM1
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Cat.#:ICAM1-946HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Intercellular Adhesion Molecule 1
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Cat.#:Icam1-2293MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Icam1, His tagged
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Cat.#:ICAM1-23MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Icam1 Protein, His-tagged
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Cat.#:Icam1-2778MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Icam1 protein, His-tagged
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Cat.#:Icam1-2779MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Icam1 protein, His-tagged
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Cat.#:ICAM1-316MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse ICAM1, MIgG2a Fc-tagged
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Cat.#:ICAM1-317MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse ICAM1, MIgG2a Fc-tagged, mutant
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Cat.#:Icam1-3323MTag:Fc|His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Icam1, Fc-His tagged
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Cat.#:Icam1-5640MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Intercellular Adhesion Molecule 1, Fc-tagged
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Cat.#:Icam1-1067RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Icam1 Protein, Fc-tagged
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Cat.#:Icam1-1793RTag:N/A
Source (Host):NS0Species:Rat
Product nameRecombinant Rat Intercellular Adhesion Molecule 1
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Cat.#:Icam1-2781RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Icam1 protein, His & T7-tagged
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Cat.#:ICAM1-2979RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ICAM1 Protein
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Cat.#:Icam1-4086RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Icam1, His tagged
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Cat.#:ICAM1-1795RTag:N/A
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ICAM1 Protein
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Cat.#:ICAM1-1796RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ICAM1 Protein, hIgG1-tagged
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Cat.#:ICAM1-1797RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ICAM1 Protein, hIgG4-tagged
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Cat.#:ICAM1-2184RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ICAM1 Protein, His-tagged
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Cat.#:ICAM1-2776DTag:His|GST
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog ICAM1 protein, His & GST-tagged
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Cat.#:ICAM1-2780PTag:His|T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig ICAM1 protein, His & T7-tagged
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Cat.#:ICAM1-2655HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICAM1 cell lysate
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Cat.#:ICAM1-2487MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ICAM1 cell lysate
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Cat.#:ICAM1-1970RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat ICAM1 cell lysate
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Involved Pathway

ICAM1 involved in several pathways and played different roles in them. We selected most pathways ICAM1 participated on our site, such as NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
TNFSF13B; GM13304; LBP; MAP3K7; XIAP; MAP3K7IP3; LCK; GM1987; CCL21; NFKB2
Cell adhesion molecules (CAMs)
MHC1UEA; CLDN23; MPZ; MHC2DEB; ITGB7; CLDN11; ICOS; CLDN15A; HLA-DRA; SDC2
Natural killer cell mediated cytotoxicity
PIK3CA; HLA-G; ULBP3; HRAS; MAP2K1; FCGR4; PAK1; TNFSF10; KLRC4-KLRK1; SHC1
TNF signaling pathway
FOS; IKBKG; IL15; ATF4; ICAM1; CREB5; IL6; MLKL; RELA; CXCL1
Leukocyte transendothelial migration
ACTN3; NCF4; MYL7; OCLN; RASSF5; CLDN2; ITGB2L; ESAM; CLDN15; MMP2
African trypanosomiasis
PLCB3; LAMA4; IL10; TLR9; IL1B2; FAS; HBA-A2; IFNG; PLCB1; HBA1
Malaria
HBA1; TGFB3; HBB-B1; TGFB2; DARC; HBB; SDC2; SELP; IL18; THBS4
Staphylococcus aureus infection
GM5077; HLA-DRB4; MBL1; FPR3; C1QA; Itgam&Itgb2; HLA-DRB5; C1QB; FCGR4; HLA-DMA
Influenza A
EIF2AK4; HLA-DPA1; NUP98; OAS1; NXF1; KPNA1; IFIH1; IRF3; AKT1; LOC100033925
HTLV-I infection
TSPO; HLA-G; RB1; NFATC3; TP53INP1; ATF3; NFKB2; RELA; WNT8A; PTTG2
Epstein-Barr virus infection
PIK3R2; H2-Q10; TYK2; GTF2B; VIM; YWHAG; RIPK1; HDAC2; YWHAZ; TRP53
Rheumatoid arthritis
ITGAL; ATP6V1B1; CXCL12; ATP6V1A; HLA-DOB; IL23; ATP6V1E2; ITGB2; HLA-DRA; Il23a; Il12b
Viral myocarditis
HLA-F; RAC1; H2-Q10; ITGB2; CD80; SGCA; HLA-E; HLA-DPB1; CAV1; ACTG1

Protein Function

ICAM1 has several biochemical functions, for example, integrin binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ICAM1 itself. We selected most functions ICAM1 had, and list some proteins which have the same functions with ICAM1. You can find most of the proteins on our site.
Function
Related Protein
Function integrin binding
Related Protein ANGPTL3; COL3A1; ADAM10; MFGE8; PTPN2; EMP2; S1PR2; TSPAN8; CTGF; WISP1A
Function protein binding
Related Protein ALPL; CIRH1A; RPS3; IKZF2; JUN; CST1; NCALD; KDM6B; HBA1; CTTNBP2NL
Function receptor activity
Related Protein ITGB1B.2; FPR1; NOTCH1A; CUBN; HTR3A; DARC; PVRL3; V1RA8; PVRL1B; PAQR9
Function transmembrane signaling receptor activity
Related Protein CD4; TRPV1; KLRF1; FZD1; TLR18; HIST2H3C2; EDAR; GLP1R; P2RX5; SPN
Function virus receptor activity
Related Protein SLC52A2; ITGB1; RPSA; CD80; SLC10A1; CCR5; F11R; CR1; LAMP1; CLEC4M

Interacting Protein

ICAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ICAM1.
ITGAL; FGG; UBC; Tubb4b; HSD3B7; EGFR; cona_canen

ICAM1 Related Articles

Cai, TT; Muhali, FS; et al. Genome-wide DNA methylation analysis in Graves' disease. GENOMICS 105:204-210(2015).
Meliton, AY; Meng, FY; et al. Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 308:L550-L562(2015).