ICAM1

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ICAM1

Official Full Name intercellular adhesion molecule 1
Background This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008] ICAM-1 (55 kDa) is a member of the immunoglobulin supergene family thatfunctions as a ligand for the Lymphocyte Function-Associated Antigen-1. It is asingle-chain glycoprotein that can be expressed on non-hematopoietic cells ofmany lineages. The role of ICAM-1 as a disease marker has been demonstrated fora number of different indications and pathological situations. ICAM-1 upregulation in allergic airway inflammation is responsible for therecruitment of activated leukocytes and the pathogenesis of allergic rhinitis.In lymphoproliferative disorders, ICAM-1 is related to the degree ofmalignancy.
Synonyms ICAM1; intercellular adhesion molecule 1; BB2; CD54; P3.58; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; ICAM
    • Species :
    • Bovine
    • Dog
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293T
    • Human Cell
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • Yeast
    • Tag :
    • Fc
    • Fc Chimera
    • Fc/Avi
    • His
    • GST
    • hIgG1
    • hIgG4
    • T7
    • human
    • IgG1
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ICAM1 Recombinant Human ICAM1 protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi
    Human ICAM1-151H Recombinant Human ICAM1 Protein, His-tagged Human Cells His
    Human CAB11556MH Mouse Anti-Human Inter-Cellular Adhesion Molecule 1 Monoclonal Antibody Mouse N/A
    Human ICAM1-101H Recombinant Human ICAM1, HIgG1 Fc-tagged CHO Fc
    Human ICAM1-102H Recombinant Human ICAM1, HIgG1 Fc-tagged, mutant CHO Fc
    Human ICAM1-146H Recombinant Human ICAM1, Fc-tagged CHO Fc
    Human ICAM1-1625H Recombinant Human Intercellular Adhesion Molecule 1, Fc Chimera Mammalian cells Fc
    Human ICAM1-2249H Recombinant Human ICAM1 protein, His-tagged HEK293 His
    Human ICAM1-22H Recombinant Human ICAM1 Protein, Fc-His-tagged Insect Cell Fc/His
    Human ICAM1-2655HCL Recombinant Human ICAM1 cell lysate Human Cell N/A
    Human ICAM1-2777H Recombinant Human ICAM1 protein, GST-tagged E.coli GST
    Human ICAM1-278H Recombinant Human Intercellular Adhesion Molecule-1, His-tagged E.coli His
    Human ICAM1-28590TH Recombinant Human ICAM1 CHO N/A
    Human ICAM1-28631TH Recombinant Human ICAM1, His-tagged E.coli His
    Human ICAM1-28924TH Recombinant Human ICAM1 E.coli N/A
    Human ICAM1-471H Recombinant Human ICAM1, Fc Chimera Mammalian cells Fc Chimera
    Human ICAM1-540H Recombinant Human ICAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ICAM1-655H Recombinant Human ICAM1 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human ICAM1-656H Recombinant Human ICAM1, Fc-His tagged Human Cell Fc/His
    Human ICAM1-657H Recombinant Human ICAM1, None tagged Human Cell N/A
    Human ICAM1-799H Recombinant Human ICAM1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ICAM1-89H Recombinant Human ICAM1 Mammalian cells N/A
    Human ICAM1-946H Recombinant Human Intercellular Adhesion Molecule 1 CHO N/A
    Mouse Icam1-1204M Recombinant Mouse Icam1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Icam1-2293M Recombinant Mouse Icam1, His tagged Human Cell His
    Mouse ICAM1-23M Recombinant Mouse Icam1 Protein, His-tagged Insect Cell His
    Mouse ICAM1-2487MCL Recombinant Mouse ICAM1 cell lysate Human Cell N/A
    Mouse Icam1-2778M Recombinant Mouse Icam1 protein, His-tagged E.coli His
    Mouse Icam1-2779M Recombinant Mouse Icam1 protein, His-tagged E.coli His
    Mouse ICAM1-316M Recombinant Mouse ICAM1, MIgG2a Fc-tagged CHO Fc
    Mouse ICAM1-317M Recombinant Mouse ICAM1, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse Icam1-3323M Recombinant Mouse Icam1, Fc-His tagged Human Cell Fc/His
    Mouse Icam1-4322M Recombinant Mouse Icam1 Protein Yeast N/A
    Mouse Icam1-5640M Recombinant Mouse Intercellular Adhesion Molecule 1, Fc-tagged Mammalian cells Fc
    Rat Icam1-1067R Recombinant Rat Icam1 Protein, Fc-tagged HEK293 Fc
    Rat Icam1-1793R Recombinant Rat Intercellular Adhesion Molecule 1 Mammalian cells N/A
    Rat ICAM1-1970RCL Recombinant Rat ICAM1 cell lysate Human Cell N/A
    Rat Icam1-2781R Recombinant Rat Icam1 protein, His & T7-tagged E.coli His/T7
    Rat ICAM1-2979R Recombinant Rat ICAM1 Protein Mammalian Cell His
    Rat Icam1-4086R Recombinant Rat Icam1, His tagged Human Cell His
    Rhesus ICAM1-1005R Recombinant Rhesus ICAM1 Protein (Met1-Glu480), His-tagged HEK293 His
    Rhesus monkey ICAM1-1795R Recombinant Rhesus Monkey ICAM1 Protein HEK293 N/A
    Rhesus monkey ICAM1-1796R Recombinant Rhesus Monkey ICAM1 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey ICAM1-1797R Recombinant Rhesus Monkey ICAM1 Protein, hIgG4-tagged HEK293 hIgG4
    Rhesus Macaque ICAM1-2184R Recombinant Rhesus monkey ICAM1 Protein, His-tagged Mammalian Cell His
    Dog ICAM1-2776D Recombinant Dog ICAM1 protein, His & GST-tagged E.coli His/GST
    Bovine ICAM1-4320B Recombinant Bovine ICAM1 Protein Yeast N/A
    Pig ICAM1-2780P Recombinant Pig ICAM1 protein, His & T7-tagged E.coli His/T7

    ICAM1 involved in several pathways and played different roles in them. We selected most pathways ICAM1 participated on our site, such as NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway LTA; TRAF3; LTB; ICAM1; MAP3K7IP3; CD40; CXCL2; TNFRSF1A; IKBKB; LTBR
    Cell adhesion molecules (CAMs) ESAM; CLDNK; CLDN4; CD86; CDH3; JAM3; Icosl; ICOS; MHC1UXA2; NEGR1
    Natural killer cell mediated cytotoxicity KIR2DS2; TNFRSF10D; MAP2K1; TNFRSF10B; TNFRSF10C; NCR3; IFNA21; H60a; IFNA17; HLA-C
    TNF signaling pathway MAP2K3; PIK3CB; VEGFC; MAPK9; ATF4; MAP2K6; CCL20; CX3CL1; MAP3K7; MMP9
    Leukocyte transendothelial migration BCAR1; CLDN6; VCL; ESAM; CLDN14; PIK3R5; CLDN4; MYL12A; RAC2; PIK3R1
    African trypanosomiasis TNF; PLCB3; HBB-B1; IL12A; LAMA4; PRKCB; HBA2; VCAM1; PLCB1; PLCB2
    Malaria CD81; HGF; THBS2; HBB-B1; MYD88; MET; DARC; HBB-B2; ITGB2; KLRC4-KLRK1
    Staphylococcus aureus infection C1R; SELPLG; C1QB; MASP1; HLA-DOB; C3AR1; ICAM1; FCGR1A; HLA-DRB3; HLA-DRB5
    Influenza A HLA-DPB1; TNFRSF10C; PIK3CB; OAS1B; IFNA1; IFNAR1; PIK3R1; IKBKE; MAPK10; IRAK4
    HTLV-I infection PDGFRA; FZD2; CRTC3; GM-CSF; DVL2; AKT1; WNT3A; TCF3; ANAPC7; ATF3
    Epstein-Barr virus infection YWHAE; HLA-C; HLA-DRA; HLA-DRB3; CR2; SHFM1; HDAC4; FGR; POLR2G; HLA-DRB1
    Rheumatoid arthritis ATP6V1C1; ATP6V1G2; H2-AA; HLA-DPB1; IL6; TLR4; CD80; ACP5; HLA-DRB4; ICAM1
    Viral myocarditis FYN; ITGB2; CASP8; HLA-DPB1; HLA-DQA1; HLA-DOB; CD40; CYCS; MYH7; HLA-E

    ICAM1 has several biochemical functions, for example, integrin binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ICAM1 itself. We selected most functions ICAM1 had, and list some proteins which have the same functions with ICAM1. You can find most of the proteins on our site.

    Function Related Protein
    integrin binding WISP1; EMP2; THBS4; ACTN4; ITGB1BP2; TNN; CTGFA; CD226; COL16A1; ACTN1
    protein binding RHOA; GZMA; SGOL1; METTL21C; PLCG1; GNAQ; BBS4; WBP11; VPREB1; NPPA
    receptor activity FPR1; TLR4; EDA2R; CD2; GRIA2B; TREM1; LILRB4; LILRA2; ITGB4; GFRA4A
    transmembrane signaling receptor activity FZD9B; OR115-6; ANTXR1; LILRA1; OR6K3; GPR124; FZD1; KLRF1; EGFR; THBD
    virus receptor activity EFNB2; TYRO3; CD209A; MRC1; CLEC4M; CLEC4G; EFNB3; PVRL4; ACE2; ITGB5

    ICAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ICAM1.

    ITGAL; FGG; UBC; Tubb4b; HSD3B7; EGFR; cona_canen

    Cai, TT; Muhali, FS; et al. Genome-wide DNA methylation analysis in Graves' disease. GENOMICS 105:204-210(2015).
    Meliton, AY; Meng, FY; et al. Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 308:L550-L562(2015).

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