ICAM1
-
Official Full Name
intercellular adhesion molecule 1 -
Overview
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008] ICAM-1 (55 kDa) is a member of the immunoglobulin supergene family thatfunctions as a ligand for the Lymphocyte Function-Associated Antigen-1. It is asingle-chain glycoprotein that can be expressed on non-hematopoietic cells ofmany lineages. The role of ICAM-1 as a disease marker has been demonstrated fora number of different indications and pathological situations. ICAM-1 upregulation in allergic airway inflammation is responsible for therecruitment of activated leukocytes and the pathogenesis of allergic rhinitis.In lymphoproliferative disorders, ICAM-1 is related to the degree ofmalignancy. -
Synonyms
ICAM1;intercellular adhesion molecule 1;BB2;CD54;P3.58;ICAM-1;cell surface glycoprotein P3.58;major group rhinovirus receptor;intercellular adhesion molecule 1 (CD54), human rhinovirus receptor;ICAM
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Rat
- Bovine
- Cynomolgus
- Dog
- Pig
- Rabbit
- Mus musculus
- HEK293
- Human Cell
- Insect Cell
- Yeast
- CHO
- Mammalian cells
- HEK293 cells
- C-His
- Mammalian Cell
- E.coli
- Mouse
- HEK293T
- Human Cells
- E.coli expression system
- His
- Non
- C-His&hFc
- His&Fc
- Fc
- Fc&Avi
- hIgG4
- His&GST
- GST
- His&T7
- His&Avi
- Flag
- Myc&DDK
- His&Fc&Avi
- His&SUMO
- mFc
Involved Pathway
ICAM1 involved in several pathways and played different roles in them. We selected most pathways ICAM1 participated on our site, such as NF-kappa B signaling pathway,Cell adhesion molecules (CAMs),Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Malaria | VCAM1,MET,Ccl12,HBB-B2,GYPC,KLRK1,SDC1,CD40,SELP,THBS1 |
| Staphylococcus aureus infection | DSG1,ITGAM,FCGR2B,HLA-DOA,FCGR4,FCGR1A,HLA-DQB1,C1QC,HLA-DPB1,MASP1 |
| Leukocyte transendothelial migration | CD99,NCF4,MYLPF,PIK3R5,PIK3R2,RAC2,CLDN6,VCL,ROCK2,GNAI3 |
| Rheumatoid arthritis | TEK,ATP6V1E2,HLA-DRB1,IL15,TLR2,ATP6V0C,ATP6V1B2,ATP6V1F,MMP1,FLT1 |
| Cell adhesion molecules (CAMs) | HLA-DRA,MAG,NEO1A,HLA-DQA1,ICOS,H2-AB1,CTLA4,CD8B1,BMA2,CD99 |
| Viral myocarditis | H2-Q10,EIF4G3,CXADR,SGCG,SGCD,CYCS,RAC2,CCND1,HLA-DQB1,CD40LG |
| NF-kappa B signaling pathway | CCL21,CD40LG,LY96,CD14,IRAK4,GM10591,BCL2,LAT,TNFSF11,CCL21B |
| HTLV-I infection | RAN,FOS,KAT2B,MAP3K3,TNFRSF13C,VDAC1,CALR,ZFP36,RB1,MYBL2 |
| Natural killer cell mediated cytotoxicity | MAP2K1,IFNA1,BID,BRAF,PRKCB,FCGR3A,KLRK1,LAT,IFNA21,IFNA5 |
Protein Function
ICAM1 has several biochemical functions, for example, integrin binding,protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ICAM1 itself. We selected most functions ICAM1 had, and list some proteins which have the same functions with ICAM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| virus receptor activity | ITGB1,ITGA2,MRC1,TFRC,F11R,LAMP1,GYPA,ITGAV,CR2,SERPINB3 |
| receptor activity | VPREB1,NOTCH1,GRIN2A,F2RL1.2,Pla2r1,SIGLEC7,PAQR3A,TEK,ANXA2R,NPC1 |
| protein binding | PFDN4,LRP1,Cd79a,DUT,PREP,ANKHD1,EIF3M,ACAA2,NCOA2,ZBTB7A |
| transmembrane signaling receptor activity | OR4N4,LEPR,TLR4,TRPV1,KLRD1,LILRA1,TLR5,TLR10, Cd79b,CD4 |
| integrin binding | CD226,SYK,CALR,ILK,GPNMB,PTPN2,COL3A1,ACTN3,LAMB1,COL4A3 |
Interacting Protein
ICAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ICAM1.
ITGAL;FGG;UBC;Tubb4b;HSD3B7;EGFR;cona_canen
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References
- Cai, TT; Muhali, FS; et al. Genome-wide DNA methylation analysis in Graves' disease. GENOMICS 105:204-210(2015).
- Meliton, AY; Meng, FY; et al. Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 308:L550-L562(2015).
