ICAM1
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Official Full Name
intercellular adhesion molecule 1
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Overview
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008] ICAM-1 (55 kDa) is a member of the immunoglobulin supergene family thatfunctions as a ligand for the Lymphocyte Function-Associated Antigen-1. It is asingle-chain glycoprotein that can be expressed on non-hematopoietic cells ofmany lineages. The role of ICAM-1 as a disease marker has been demonstrated fora number of different indications and pathological situations. ICAM-1 upregulation in allergic airway inflammation is responsible for therecruitment of activated leukocytes and the pathogenesis of allergic rhinitis.In lymphoproliferative disorders, ICAM-1 is related to the degree ofmalignancy. -
Synonyms
ICAM1; intercellular adhesion molecule 1; BB2; CD54; P3.58; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; ICAM;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Bovine
- Canis lupus familiaris (Dog) (Canis familiaris)
- Dog
- Gln28-Val480
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Pig
- Rabbit
- Rat
- Rattus norvegicus (Rat)
- Rhesus
- Rhesus Macaque
- Rhesus monkey
- C-His
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293 cells
- HEK293T
- Human Cell
- Human Cells
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Mouse
- Yeast
- C
- His
- hFc
- Fc
- Avi
- Flag
- GST
- hIgG4
- SUMO
- T7
- mFc
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ICAM1 involved in several pathways and played different roles in them. We selected most pathways ICAM1 participated on our site, such as NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | TRAF1;GM10591;IRAK1;NFKB2;LCK;PRKCQ;BCL2;IL1B;TRAF2 |
| Cell adhesion molecules (CAMs) | H2-Q10;HLA-DQB1;CD40LG;MAG;MADCAM1;NCAM1;CLDN15A;CLDN3;CLDN22 |
| Natural killer cell mediated cytotoxicity | ULBP3;PTK2B;PIK3R1;PLCG1;FCGR3A;IFNA14;RAET1D;SYK;PRKCB |
| TNF signaling pathway | ATF4;MAGI2;IL6;MAPK11;MAPK10;IL15;RIPK1;FADD;TNFAIP3 |
| Leukocyte transendothelial migration | MYL10;PIK3R3;NCF4;Itgam&Itgb2;NCF1;NCF2;MYL9;PIK3CG;MMP2 |
| African trypanosomiasis | HBA-A2;IFNG;Fasl;PRKCB;APOL1;THOP1;IL12A;HBB-B1;IL1B2 |
| Malaria | THBS1;KLRK1;CSF3;IL1B;TLR9;VCAM1;ICAM1;TGFB1;HBA2 |
| Staphylococcus aureus infection | C1QA;HLA-DMB;ITGB2;FPR3;C2;C5;FCGR3A;C1RA;ICAM1 |
| Influenza A | HLA-DMB;FASLG;MYD88;PRKCA;OAS2;IFNA5;PIK3CG;RSAD2;IL6 |
| HTLV-I infection | WNT6;HLA-DRB3;CD3E;RELB;CD3D;MSX2;PDGFA;POLD4;PDGFB |
| Epstein-Barr virus infection | POLR2C;EIF2AK3;MAPK12;PIK3CA;HLA-DPA1;RELB;NEDD4;CD40;YWHAH |
| Rheumatoid arthritis | ATP6AP1;H2-AA;TLR2;ANGPT1;HLA-DQA1;ATP6V0B;CD80;TEK;HLA-DQB1 |
| Viral myocarditis | CXADR;HLA-DRB1;ICAM1;CYCS;HLA-DPB1;HLA-DQA1;ABL2;ACTG1;ITGAL |
ICAM1 has several biochemical functions, for example, integrin binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ICAM1 itself. We selected most functions ICAM1 had, and list some proteins which have the same functions with ICAM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | TIMP2;DST;CALR;NISCH;CTGFA;ITGA5;WISP1B;ANGPTL3;THBS4 |
| protein binding | MRPL12;SCAF8;DLX4;PLSCR3;HIPK4;SUPT6H;KCTD15;FMNL1;USP34 |
| receptor activity | GFRA1A;NLGN2;CADM1A;LILRB2;VMN1R44;DERL1;MRC1;CD93;NPY2R |
| transmembrane signaling receptor activity | CD4;CD3G;TNFRSF10C;DNER;IL27RA;M6PR;Fzd4;TNFRSF8;OR115-6 |
| virus receptor activity | ITGB7;CR1;SIVA1;CR2;CXADR;HSPA1B;PVRL1;IDE;XPR1 |
ICAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ICAM1.
ITGAL; FGG; UBC; Tubb4b; HSD3B7; EGFR; cona_canen
Research Area
Related articles
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Customer Reviews (3)
Write a reviewManufacturers may provide documentation of the protein's validation, which includes information about its purity, concentration, stability, and potential contaminants.
This can be particularly important in clinical trials to ensure accurate and reliable results.
If the need arises for larger quantities of ICAM1 protein during the later stages of clinical trials, the manufacturer can facilitate scale-up production processes to meet those requirements.
Q&As (5)
Ask a questionYes, targeting ICAM1 is being explored as a potential therapeutic strategy for inflammatory diseases, with research focusing on developing ICAM1 inhibitors.
ICAM1 is upregulated during inflammation, promoting the adhesion of immune cells to the endothelium and facilitating their migration into inflamed tissues.
ICAM1 expression can be altered in cancer cells and is implicated in promoting cancer progression by facilitating tumor cell adhesion, invasion, and metastasis.
ICAM1 levels can be measured in blood or tissue samples, and elevated levels may serve as diagnostic markers for certain inflammatory diseases.
Elevated levels of ICAM1 in some diseases may serve as prognostic markers, indicating disease severity and potential outcomes.
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