Recombinant Human ICAM1, Fc-His tagged

• Cat.No.: ICAM1-656H
• Product Overview: Recombinant Human ICAM1 extracellular domain (Met 1-Glu 480) (NP_000192.2), fused with the polyhistidine-tagged Fc region of human IgG1 at the C-terminus, was produced in Human Cell.

Specification

• Source: Human Cells
• Species: Human
• Tag: His&Fc
• Form: Lyophilized from sterile PBS, pH 7.4
• Molecular Mass: The recombinant human ICAM1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 700 amino acids and has a predicted molecular mass of 77.4 kDa. As a result of glycosylation, the apparent molecular mass of rh ICAM1/Fc monomer migrates with an apparent molecular mass of 100-110 kDa in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Stability: Samples are stable for up to twelve months from date of receipt at -70oC.
• Storage: Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
• Protein length: Met1-Glu480

Gene Information

• Gene Name: ICAM1 intercellular adhesion molecule 1 [ Homo sapiens ]
• Official Symbol: ICAM1
• Gene ID: 3383
• mRNA Refseq: NM_000201
• Protein Refseq: NP_000192
• MIM: 147840
• UniProt ID: P05362

Reviews

04/27/2022

Manufacturers may provide documentation of the protein's validation, which includes information about its purity, concentration, stability, and potential contaminants.

11/05/2020

This can be particularly important in clinical trials to ensure accurate and reliable results.

10/14/2016

If the need arises for larger quantities of ICAM1 protein during the later stages of clinical trials, the manufacturer can facilitate scale-up production processes to meet those requirements.

Q&As

Can ICAM1 be a potential therapeutic target?

Yes, targeting ICAM1 is being explored as a potential therapeutic strategy for inflammatory diseases, with research focusing on developing ICAM1 inhibitors.

How is ICAM1 involved in inflammation?

ICAM1 is upregulated during inflammation, promoting the adhesion of immune cells to the endothelium and facilitating their migration into inflamed tissues.

How is ICAM1 involved in cancer progression?

ICAM1 expression can be altered in cancer cells and is implicated in promoting cancer progression by facilitating tumor cell adhesion, invasion, and metastasis.

Are there diagnostic applications for ICAM1 in clinical settings?

ICAM1 levels can be measured in blood or tissue samples, and elevated levels may serve as diagnostic markers for certain inflammatory diseases.

Can ICAM1 be used as a prognostic marker in certain diseases?

Elevated levels of ICAM1 in some diseases may serve as prognostic markers, indicating disease severity and potential outcomes.