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Recombinant Human ICAM1 protein, GST-tagged

Cat.No. : ICAM1-2777H
Product Overview : Recombinant Human ICAM1 aa. (Asn26~Glu480 (Accession # P05362)) fused with N-terminal GST tag was produced in E. coli cells.
  • Specification
  • Gene Information
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Description : This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
Source : E. coli
Species : Human
Tag : GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 75.8kDa
Protein length : Asn26~Glu480 (Accession # P05362)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 5.8.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : ICAM1 intercellular adhesion molecule 1 [ Homo sapiens (human) ]
Official Symbol : ICAM1
Synonyms : BB2; CD54; P3.58; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; major group rhinovirus receptor; intercellular adhesion molecule 1
Gene ID : 3383
mRNA Refseq : NM_000201.2
Protein Refseq : NP_000192.2
UniProt ID : P05362

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can ICAM1 be a potential therapeutic target? 07/11/2021

Yes, targeting ICAM1 is being explored as a potential therapeutic strategy for inflammatory diseases, with research focusing on developing ICAM1 inhibitors.

How is ICAM1 involved in inflammation? 07/09/2020

ICAM1 is upregulated during inflammation, promoting the adhesion of immune cells to the endothelium and facilitating their migration into inflamed tissues.

How is ICAM1 involved in cancer progression? 07/07/2019

ICAM1 expression can be altered in cancer cells and is implicated in promoting cancer progression by facilitating tumor cell adhesion, invasion, and metastasis.

Are there diagnostic applications for ICAM1 in clinical settings? 01/13/2017

ICAM1 levels can be measured in blood or tissue samples, and elevated levels may serve as diagnostic markers for certain inflammatory diseases.

Can ICAM1 be used as a prognostic marker in certain diseases? 08/13/2016

Elevated levels of ICAM1 in some diseases may serve as prognostic markers, indicating disease severity and potential outcomes.

Customer Reviews (3)

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Reviews
04/27/2022

    Manufacturers may provide documentation of the protein's validation, which includes information about its purity, concentration, stability, and potential contaminants.

    11/05/2020

      This can be particularly important in clinical trials to ensure accurate and reliable results.

      10/14/2016

        If the need arises for larger quantities of ICAM1 protein during the later stages of clinical trials, the manufacturer can facilitate scale-up production processes to meet those requirements.

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